Results 51 to 60 of about 883,299 (307)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

COMPUTER-AIDED DESIGN OF MECHATRONIC MACHINE EQUIPMENT LAYOUTS USING THE SOLIDWORKS SOFTWARE PACKAGE

Современная наука и инновации, 2023
The article proposes a technique for carrying out preliminary design of mechatronic machine tools using the SolidWorks computer-aided design system.
M. P. Afanasyev, T. F. Tuliakov
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Application Isssues of the Semi-Markov Reliability Model

Polish Maritime Research, 2015
Predicting the reliability of marine internal combustion engines, for instance, is of particular importance, as it makes it possible to predict their future reliability states based on the information on the past states. Correct reliability prediction is
Rudnicki Jacek
doaj   +1 more source

Graphics based preliminary structural design

, 2018
: "The development of graphic based preliminary design programs is appealing because preliminary design involves the consideration of alternatives as concepts or sketches.
Mary Lou. Maher (5048360), Weiguang Zhang (5355047), Carnegie Mellon University.Engineering Design Research Center. (5047289)   +2 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

A Custom Genetic Algorithm Framework for Early-Stage Optimization of Electromechanical Actuators

Actuators
This work presents a systematic methodology for the preliminary design and optimization of electromechanical actuators, aimed at minimizing overall mass and rotational inertia while satisfying torque and speed requirements.
Michelangelo Levati, Antonio Carlo Bertolino, Roberto Guida, Domenico Fabio Migliore, Edoardo Finamore, Massimo Sorli   +5 more
doaj   +1 more source

Regression Formulas for The Estimation of Engine Total Power for Tankers, Container Ships and Bulk Carriers on The Basis of Cargo Capacity and Design Speed

Polish Maritime Research, 2019
This article presents regression formulas for the preliminary design of tankers, bulk carriers and container vessels, based on the data of ships built from 2000 to 2018.
Cepowski Tomasz
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Inheritance and Optimization of Mechanical Traits for Hybrid Girder Bridges: A Novel Bionic Perspective

Buildings
Hybrid girder bridges can be likened to plant grafting, where mechanical traits are inherited from both rootstock and scion girders, enabling performance that exceeds that of the individual components.
Bing Shangguan, Qingtian Su, Junyong Zhou, Liang Dai   +3 more
doaj   +1 more source