Results 71 to 80 of about 755,343 (256)

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

Preliminary Design

open access: yes
The aim of the preliminary design deliverable is for NTNU to develop and document a feasible overall design of the Xrotor wind turbine that fulfills the requirements documented in the design basis deliverable D51 It is the main output of Task 44 but will be developed in close collaboration with WP3 WP4 and WP6 NTNU will integrate results from the ...
openaire   +3 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Towards a Comprehensive Hydrodynamic Model for the Feasibility Study of Motor Yachts

open access: yesJournal of Marine Science and Engineering
The design process for motor yachts primarily relies on the experience of designers, who draw upon their knowledge gained from working on similar hull forms.
Francesco Mauro   +6 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Validity of the Shear Panel Theory as a Reduced Modelling Approach

open access: yesEngineering Proceedings
The increasing complexity of large-scale thin-walled structures can be handled by using a hierarchical modelling approach. However, in structural engineering a true preliminary design phase is frequently skipped, since reduced models are often either ...
Moritz Bäß, Kai-Uwe Schröder
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

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