Results 41 to 50 of about 628,808 (263)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
The ideal victims? Women with intellectual disability as victims of prostitution-related crime
Scandinavian Journal of Disability Research, 2013 In Sweden several recent prostitution-related offences where the victims were women with intellectual disabilities (IDs) have created problems for criminal investigators and prosecutors.
Jari Kuosmanen, Mikaela Starke
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Preliminary investigation of a novel mouthguard
International Journal of Preventive Medicine, 2018 Mouthguards (MGs) remain an important piece of personal protection for athletes for the prevention of injury. Although MGs provide tremendous benefits, the design and fabrication process does not record the position of the mandible or the occlusion, which could lead to injury. This study compared a novel MG to over-the-counter (OTC) and custom MGs on a
openaire +3 more sources
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Learning algebraic structures: Preliminary investigations
International Journal of Data Science in the Mathematical Sciences, 2022 In this paper, we employ techniques of machine learning, exemplified by support vector machines and neural classifiers, to initiate the study of whether artificial intelligence (AI) can “learn” algebraic structures. Using finite groups and finite rings as a concrete playground, we find that questions such as identification of simple groups by “looking”
Yang-Hui He, Minhyong Kim
openaire +2 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
The Language of Intoxication: Preliminary Investigations [PDF]
Alcoholism: Clinical and Experimental Research, 2009 Background: The extensive vocabulary individuals use to describe alcohol’s subjective effects has largely gone unexamined in contemporary alcohol research. The present study examined the language drinkers use to describe their own intoxication. It is argued that this language can provide a more complete characterization of alcohol’s subjective effects
Ash, Levitt +2 more
openaire +2 more sources