Results 41 to 50 of about 2,274,130 (308)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
preliminary investigation [PDF]
Medicine & Science in Sports & Exercise, 2014 Douglas N. Martini +2 more
+5 more sources
IDENTIFICATION OF CIRCUMSTANCES CONTRIBUTING TO DOMESTIC VIOLENCE: UNDERSTANDING, IMPLEMENTATION [PDF]
Legal BulletinThe relevance of the study of the procedural order of identifying the circumstances that contributed to the commission of domestic violence is associated with the accentuation of this issue in the social sphere, the presence of problems in regulating the
BELYAEVA S.O., ZASHLYAPIN L.A.
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Barcode Annotations for Medical Image Retrieval: A Preliminary Investigation
, 2015 This paper proposes to generate and to use barcodes to annotate medical images and/or their regions of interest such as organs, tumors and tissue types. A multitude of efficient feature-based image retrieval methods already exist that can assign a query ...
Tizhoosh, Hamid R.
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Preliminary investigation of the electrodynamics of a conducting tether [PDF]
, 1985 An introductory study of the properties of an electrically conducting tether flown from the shuttle is presented. Only a single configuration is considered: a vertical conductor moving normally across the Earth's field, connecting the shuttle to a large ...
Thompson, W. B.
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
EVOLUTION OF THE ORDER OF STORAGE OF MATERIAL EVIDENCE [PDF]
Legal BulletinThe relevance of the study of the problems of storage of material evidence is predetermined by the Russian legislator, who in the current criminal procedure law has increased the number of regulatory norms devoted to the procedure for storing the said ...
FEDOROVA POLINA, ZASHLYAPIN LEONID
doaj +1 more source