Results 61 to 70 of about 2,274,130 (308)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Forensic Use of Traces

Сибирское юридическое обозрение, 2019
The article outlines some issues of using traces in the preliminary investigation and in the judicial review of a criminal case at the stage of judicial investigation.
N. V. Karepanov
doaj   +1 more source

Preliminary Investigation of the Incidence and Impact of Disability on Irish Farms [PDF]

, 2007
Farming is identified as being a hazardous occupation, resulting in disability and numerous fatalities each year. While occupational health and safety issues among farm households have been studied recently in Ireland, there has been no research directed
Connolly, Liam, McNamara, John, Ruane, Dermot J, Whelan, Shane   +3 more
core   +2 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Analysis of the Opportunity to Include Intelligence Officers in the Category of Special Criminal Investigation Bodies

Journal of Danubian Studies and Research, 2013
Situations referred to in art. 3 of Law no. 51/1991 on Romania's national security (national security threats) and Law No. 78 of 8 May 2000 on preventing, discovering and sanctioning of corruption, law no.
Bogdan Bîrzu
doaj  

IMPROVING THE CRIMINAL PROCEDURE MECHANISM OF THE INSTITUTE FOR SEARCHING FOR SUSPECTS IN CRIMES RELATED TO THE INVOLVEMENT OF RUSSIAN YOUNG PEOPLE IN TERRORIST AND EXTREMIST ORGANIZATIONS

Правовое государство: теория и практика
One of the urgent issues in the detection of crimes related to the involvement of Russian young people in terrorist and extremist organizations and bringing perpetrators to criminal responsibility is the escape of suspects from preliminary ...
AZARENOK Nikolay Vasilyevich
doaj   +1 more source

Systematic characterization of thermodynamic and dynamical phase behavior in systems with short-ranged attraction

, 2007
In this paper we demonstrate the feasibility and utility of an augmented version of the Gibbs ensemble Monte Carlo method for computing the phase behavior of systems with strong, extremely short-ranged attractions.
D. R. Reichman, K. Dawson, P. Charbonneau, S. Asakura, W. B. Russel   +4 more
core   +2 more sources

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

A Preliminary Investigation: Feasibility of an Interactive Multimedia Application In Increasing Knowledge And Awareness Of Cyber Bullying Among Adolescents

Journal of Computing Research and Innovation, 2018
This paper describes a preliminary investigation of how the capabilities of an interactive multimedia application may be used to raise understanding and awareness towards cyber bullying among adolescents.
Nadia Abdul Wahab, Wan Ahmad Jaafar Wan Yahaya   +1 more
doaj  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source