Results 81 to 90 of about 549,227 (264)

Occurrence and Temporal Variation of Technology-Critical Elements in North Sea Sediments-A Determination of Preliminary Reference Values. [PDF]

open access: yesArch Environ Contam Toxicol, 2022
Klein O   +5 more
europepmc   +1 more source

Very preliminary reference Moon model

open access: yesPhysics of the Earth and Planetary Interiors, 2011
Abstract The deep structure of the Moon is a missing piece to understand the formation and evolution of the Earth–Moon system. Despite the great amount of information brought by the Apollo passive seismic experiment (ALSEP), the lunar structure below deep moonquakes, which occur around 900 km depth, remains largely unknown.
Garcia, Raphaël   +3 more
openaire   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim   +4 more
wiley   +1 more source

Clinical characteristics and diagnostic accuracy of preliminary diagnoses in adults with infections in Danish emergency departments: a multicentre combined cross-sectional and diagnostic study

open access: yesBMJ Open
Objective Rapid and accurate infection diagnosis is a prerequisite for appropriate antibiotic prescriptions in an ED. Accurately diagnosing acute infections can be difficult due to nonspecific symptoms and limitations of diagnostic testing.
Ole Graumann   +14 more
doaj   +1 more source

Development of a pin-less reference head frame: An experimental setup and preliminary experiences

open access: yesInterdisciplinary Neurosurgery, 2018
Objectives: Advantages of image guidance in neurosurgical procedures are undisputed. Although some approaches of flexible technologies already exist, today's gold standard for neuronavigation is the pin-assisted head clamp fixation. A reference tool that
A. Carolus   +4 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

open access: yesFEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow   +12 more
wiley   +1 more source

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