Results 61 to 70 of about 582,058 (303)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Protecting the Jewel in the Crown: The Ognyanov Case and the Preliminary Reference Procedure

open access: yesEuropean Papers, 2017
(Series Information) European Papers - A Journal on Law and Integration, 2017 2(1), 393-401 | European Forum Insight of 11 April 2017 | (Table of Contents) I. The Ognyanov case. - I.1. The facts and the preliminary reference. - I.2.
Francisco Pereira Coutinho
doaj   +1 more source

Preliminary Reference and the Hungarian Constitutional Court: A Context of Non-Reference [PDF]

open access: yesGerman Law Journal, 2015
Jiri Zemanek, Professor at Charles University, Prague, asks what conclusions may be drawn from the current state of acceptance of the European Union (EU) law doctrine by the constitutional courts of the new Member States for their performance in the agenda of preliminary rulings. What can they learn from the experience of the old Member States?
openaire   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

REFERENCE FOR A PRELIMINARY RULING ON CJEU: THOUGHTS AND OBSERVATIONS IN CRIMINAL MATTERS

open access: yesRevista de Estudos Jurídicos da UNESP, 2020
Purpose of this investigation is to give answers and make a technical/procedural overview on preliminary reference in criminal matters as well as to examine the application of art. 267 TFEU in the context of criminal proceedings.
Dimitris Liakopoulos
doaj   +1 more source

Mostly Harmless: the Referring Court in the Preliminary Reference Procedure

open access: yes, 2022
The preliminary ruling procedure remains an essential vehicle for the development of European Union law. The procedure is a two-court endeavour—a “dialogue between one court and another”, as the European Court of Justice has repeatedly characterised it ...
Wallerman Ghavanini, Anna,
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Access to Written Submissions in Preliminary Reference Proceedings: An Evaluation of the CJEU Statute Reform and its Contribution to Open Justice

open access: yesEuropean Papers
(Series Information) European Papers - A Journal on Law and Integration, 2025 10(2), 357-389 | Article | (Table of Contents) 1. Introduction. – 2. Open justice and human rights: ensuring transparency and accountability through public access. – 2.1.
Ilaria Fevola, Stefano Montaldo
doaj   +1 more source

Preliminary Study on Reference Interval of Serum Pepsinogen in Healthy Subjects

open access: yesPatient Preference and Adherence, 2021
Liang Zhang, Ye Niu, Yin-Jiang Lv, Li-Feng Wu, Qi-Lei Hu, Rong Huang, Ru-Jin Xu Department of Clinical Laboratory, First People’s Hospital of Linping District, Hangzhou, Zhejiang, 311100, People’s Republic of ChinaCorrespondence: Ru-Jin XuDepartment of ...
Zhang L   +6 more
doaj  

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