Results 41 to 50 of about 2,215,308 (245)

Risk of Population Extinction from Periodic and Abrupt Changes of Environment

, 2008
A simulation model of a population having internal (genetic) structure is presented. The population is subject to selection pressure coming from the environment which is the same in the whole system but changes in time.
Andrzej Pękalski, Bak, Bena, Bokowska, Bürger, Chowdhury, Drossel, Droz, Fraser, Goodman, Hall, Higgs, La Barbera, Lande, Lande, Marcel Ausloos, Murray, Pawlikowski, Pease, Rikvold, Roberts, Shaffer, Shnerb, Shnerb, Stauffer, Vanderwalle, Zawierta   +26 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Light Ion Accelerating Line (L3IA): Test Experiment at ILIL-PW

, 2018
The construction of a novel Laser driven Light Ions Acceleration Line(L3IA) is progressing rapidly towards the operation, following the recent upgrade of the ILIL-PW laser facility.
Baffigi, F., Brandi, F., Bussolino, G., Cristoforetti, G., Fazzi, A., Fulgentini, L., Giove, D., Gizzi, L. A., Koester, P., Labate, L., Maero, G., Palla, D., Romé, M., Tomassini, P.   +13 more
core   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Higher-loop amplitudes in the non-minimal pure spinor formalism

, 2009
We analyze the properties of the non-minimal pure spinor formalism. We show that Siegel gauge on massless vertex operators implies the primary field constraint and the level-matching condition in closed string theory by reconstructing the integrated ...
Grassi, Pietro Antonio, Vanhove, Pierre
core   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

General relativistic simulations of binary black hole-neutron stars: Precursor electromagnetic signals

, 2013
We perform the first general relativistic force-free simulations of neutron star (NS) magnetospheres in orbit about spinning and non-spinning black holes.
Etienne, Zachariah B., Paschalidis, Vasileios, Shapiro, Stuart L.   +2 more
core   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Human acclimation and acclimatization to heat: A compendium of research, 1968-1978 [PDF]

s and annotations of the majority of scientific works that elucidate the mechanisms of short-term acclimation to heat in men and women are presented. The compendium includes material from 1968 through 1977.
Fox, S. C., Greenleaf, J. E., Sciaraffa, D., Stockmann, R.   +3 more
core   +1 more source