Results 61 to 70 of about 2,227,232 (332)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Organisation of the internal functioning of the State's judiciary and the principle of subsidiarity and respect for Member States' competences.

Eastern European Journal of Transnational Relations
The article examines the division of competences between the European Union and its Member States in the light of the judgment of the Court of Justice of the European Union (CJEU) in joined cases C 748/19 to C 754/19. The analysis focuses on two closely
Marcin Sokołowski
doaj   +1 more source

Measuring person-centred care in German nursing homes – exploring the construct validity of the Dementia Policy Questionnaire: a cross-sectional study of a secondary data set

BMC Geriatrics, 2022
Background To ensure the sustainable implementation of dementia-specific person-centred care (PCC) in nursing homes, internal policies are crucial. The preliminary German Dementia Policy Questionnaire, which features 19 dichotomous items, assesses the ...
Anna Louisa Hoffmann, Johannes Michael Bergmann, Anne Fahsold, René Müller-Widmer, Martina Roes, Bernhard Holle, Rebecca Palm   +6 more
doaj   +1 more source

Studies of bosons in optical lattices in a harmonic potential

, 2007
We present a theoretical study of bose condensation and specific heat of non-interacting bosons in finite lattices in harmonic potentials in one, two, and three dimensions.
A. N. Das, Anderson, Anglin, Bagnato, Bradley, Dalfovo, Davis, Dickerscheid, Giampaolo, Greiner, Heidarian, Ho, Jaksch, Ketterle, Kinast, Kleinert, Köhl, Köhl, Köhl, Leggett, Oosten, Pai, Paredes, Pollet, Pupillo, R. Ramakumar, Rey, Rey, S. Sil, Santos, Scarola, Schori, Sengupta, Stöferle, Wessel   +34 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The Context Influence Model (CIM)Context cues in commercials make the difference

Doxa Comunicación
The COVID-19 pandemic modified consumers’ lives, but advertising did not reflect this change. Preliminary studies have found that commercials do not show anti-COVID measures, and this lack of pandemic references in advertising could affect the consumers’
Emma Rodero, Sara Vinyals-Mirabent, Isabel Rodríguez de Dios, Olatz Larrea   +3 more
doaj   +1 more source

Dataset for Phase I randomized clinical trial for safety and tolerability of GET 73 in single and repeated ascending doses including preliminary pharmacokinetic parameters

Data in Brief, 2017
The data in this article outline the methods used for the administration of GET 73 in the first time-in-human manuscript entitled “Phase I randomized clinical trial for the safety, tolerability and preliminary pharmacokinetics of the mGluR5 negative ...
Carolina L. Haass-Koffler, Kimberly Goodyear, Victoria M. Long, Harrison H. Tran, Antonella Loche, Roberto Cacciaglia, Robert M. Swift, Lorenzo Leggio   +7 more
doaj   +1 more source

Grid Vertex-Unfolding Orthogonal Polyhedra

, 2006
An edge-unfolding of a polyhedron is produced by cutting along edges and flattening the faces to a *net*, a connected planar piece with no overlaps. A *grid unfolding* allows additional cuts along grid edges induced by coordinate planes passing through ...
Damian, Mirela, Flatland, Robin, O'Rourke, Joseph   +2 more
core   +3 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

THE OBJECT OF THE PRELIMINARY QUESTION [PDF]

Challenges of the Knowledge Society, 2012
The study intends to explain what may be the object of a preliminary question sent by a national court or tribunal of a member state to the Court of Justice of the European Union (CJEU), analyzing the first paragraph of article 267 of the Treaty on the ...
IULIANA-MĂDĂLINA LARION
doaj