Results 51 to 60 of about 231,822 (258)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

The Context Influence Model (CIM)Context cues in commercials make the difference

open access: yesDoxa Comunicación
The COVID-19 pandemic modified consumers’ lives, but advertising did not reflect this change. Preliminary studies have found that commercials do not show anti-COVID measures, and this lack of pandemic references in advertising could affect the consumers’
Emma Rodero   +3 more
doaj   +1 more source

THE OBJECT OF THE PRELIMINARY QUESTION [PDF]

open access: yesChallenges of the Knowledge Society, 2012
The study intends to explain what may be the object of a preliminary question sent by a national court or tribunal of a member state to the Court of Justice of the European Union (CJEU), analyzing the first paragraph of article 267 of the Treaty on the ...
IULIANA-MĂDĂLINA LARION
doaj  

The Minnesota Union List of Serials

open access: yesInformation Technology and Libraries, 1973
This paper describes development of a MARC serials format union catalog of serials called the Minnesota Union List of Serials (MULS). The Preliminary Edition, published August 1972, contains over 37,000 main entries in 1,566 text pages produced through ...
Audrey N. Grosch
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Typical performance of elderly patients with Alzheimer disease on the Wisconsin Card Sorting Test (WCST)

open access: yesDementia & Neuropsychologia
The Wisconsin Card Sorting Test (WCST) is a neuropsychological assessment tool designed to assess executive functions, frequently used in cases of cognitive disorders.
José Humberto Silva-Filho   +2 more
doaj   +1 more source

Measuring person-centred care in German nursing homes – exploring the construct validity of the Dementia Policy Questionnaire: a cross-sectional study of a secondary data set

open access: yesBMC Geriatrics, 2022
Background To ensure the sustainable implementation of dementia-specific person-centred care (PCC) in nursing homes, internal policies are crucial. The preliminary German Dementia Policy Questionnaire, which features 19 dichotomous items, assesses the ...
Anna Louisa Hoffmann   +6 more
doaj   +1 more source

PLM Reference Model: A Preliminary Proposal for Reference Model Evolution [PDF]

open access: yes, 2012
The adoption of product lifecycle management (PLM) business approach requires the implementation of PLM systems. Currently there is a wide variety of PLM systems in the market, but the scope differences between existing systems hamper the selection process for manufacturing companies.
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

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