Results 131 to 140 of about 9,691,387 (324)

DNA repair in premature aging disorders and neurodegeneration

, 2010
The accumulation of DNA damage has been widely implicated in premature aging and neurodegeneration. Progeroid syndromes with defects in the cellular response to DNA damage suggest that progressive genome instability represents an important aspect of the ...
COPPEDE', FABIO, MIGLIORE, LUCIA
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Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells [PDF]

, 2011
Copyright @ 2011 Mehta et al.; licensee BioMed Central Ltd. This article has been made available through the Brunel Open Access Publishing Fund. This is an open access article distributed under the terms of the Creative Commons Attribution License ...
Christopher H Eskiw, Ishita S Mehta, Halime D Arican, Kill, IR, Arican, HD, Eskiw, CH, Bridger, JM, Joanna M Bridger, Mehta, IS, Ian R Kill   +9 more
core   +1 more source

Added Prognostic Value of EEG Reactivity in Comatose Patients Following Cardiac Arrest

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the added prognostic value of EEG reactivity for favorable outcome compared with background analysis during and after targeted temperature management (TTM). Methods Prospective observational cohort study of comatose post–cardiac arrest patients admitted to a single academic center between 2017 and 2022, all undergoing ...
Sarah Caroyer, Marie Obrecht, Charlotte de Maeseneire, Charlotte Damien, Chantal Depondt, Lorenzo Ferlini, Estelle Rikir, Filippo Annoni, Fabio Silvio Taccone, Nicolas Mavroudakis, Benjamin Legros, Nicolas Gaspard   +11 more
wiley   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

p53 isoforms regulate premature aging in human cells

Oncogene, 2018
Cellular senescence is a hallmark of normal aging and aging-related syndromes, including the premature aging disorder Hutchinson-Gilford Progeria Syndrome (HGPS), a rare genetic disorder caused by a single mutation in the LMNA gene that results in the ...
Natalia von Muhlinen, I. Horikawa, Fatima Alam, Kazunobu Isogaya, Delphine Lissa, B. Vojtesek, D. Lane, C. Harris   +7 more
semanticscholar   +1 more source

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Trophoblast Extracellular Vesicles as Modulators of Keratinocyte Stress Response and Senescence

Life
Keratinocyte stress, caused by various intrinsic and extrinsic factors, contributes to the overall aging process. D-galactose-induced metabolic/oxidative stress is a commonly used in vitro model for studying premature aging. Due to their rich composition
Mirjana Nacka-Aleksić, Andrea Pirković, Aleksandra Vilotić, Maja Kosanović, Dragana Dekanski, Janko Legner, Milica Jovanović Krivokuća   +6 more
doaj   +1 more source

Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption

, 2017
: Recent research has proposed that GIT2 (G protein-coupled receptor kinase interacting protein 2) acts as an integrator of the aging process through regulation of 'neurometabolic' integrity. One of the commonly accepted hallmarks of the aging process is
van Gastel, Jaana, Abdelkrim Azmi, Siddiqui, Sana, Sankar, Mathavi, Jaana van Gastel, Becker, Kevin G, Yongqing Zhang, Daimon, Caitlin M, Taub, Dennis D, Premont, Richard T., Stuart Maudsley, Richard T. Premont, Zhang, Yongqing, Martin, Bronwen, Taub, Dennis D., Bronwen Martin, Wood, William, Martin, James G., Daimon, Caitlin M., Arnell Carter, Becker, Kevin G., Mathavi Sankar, Kevin G. Becker, William Wood, Janssens, Jonathan, Azmi, Abdelkrim, Elin Lehrmann, Carter, Arnell, Sana Siddiqui, Ana Lustig, Etienne, Harmonie, Lehrmann, Elin, Lustig, Ana, Jonathan Janssens, James G. Martin, Dennis D. Taub, Maudsley, Stuart, Caitlin M. Daimon, Harmonie Etienne, Premont, Richard T, Wood, William, III, Martin, James G   +41 more
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Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Cellular aging in cardiovascular diseases [PDF]

, 2010
As we progress to a society with an increasing average age, the problems that are associated with advanced age becoming more prominent. This is particularly visible by the increase onset of aging associated diseases, such as atherosclerosis, heart ...
Oeseburg, Hisko,, Oeseburg, Hisko
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