Results 151 to 160 of about 9,691,387 (324)
Molecular Mechanisms Underlying Accelerated Aging by Defects in the FGF23-Klotho System
International Journal of Nephrology, 2018 The basic research of aging has been primarily focused on elucidating mechanisms of aging and longevity that are evolutionarily conserved from yeasts to primates.
Makoto Kuro-o
doaj +1 more source
Cell Stem Cell, 2019 Summary Hematopoietic stem cells (HSCs) residing in the bone marrow (BM) accumulate during aging but are functionally impaired. However, the role of HSC-intrinsic and -extrinsic aging mechanisms remains debated.
Ya‐Hsuan Ho +19 more
semanticscholar +1 more source
Arthritis Care &Research, EarlyView.People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley +1 more source
Lack of telomerase reduces cancer incidence and increases lifespan of zebrafish tp53 M214K mutants
Scientific ReportsTelomerase activity is restricted in humans and telomere attrition occurs in several tissues accompanying natural aging. Critically short telomeres trigger DNA damage responses and activate p53 which leads to apoptosis or replicative senescence.
Naz Şerifoğlu +2 more
doaj +1 more source
Premature Aging and Premature Age-Related Comorbidities in HIV-Infected Patients: Facts and Hypotheses [PDF]
Clinical Infectious Diseases, 2011 In the present issue of Clinical Infectious Diseases, Guaraldi et al [ 5 ] analyze the important cohort of patients followed up at the Metabolic Clinic of Modena (Italy) who underwent a complete set of clinical, biological, and imaging investigations, allowing investigation of comorbidities.
openaire +2 more sources
A-type lamins and cardiovascular disease in premature aging syndromes.
Current Opinion in Cell Biology, 2017 Lamin A is a nuclear intermediate filament protein with important structural and regulatory roles in most differentiated mammalian cells. Excessive accumulation of its precursor prelamin A or the mutant form called 'progerin' causes premature aging ...
B. Dorado, V. Andrés
semanticscholar +1 more source
Associations of Rheumatoid Arthritis Disease Activity With Frailty Over Five Years of Follow‐up
Arthritis Care &Research, EarlyView.Objective To evaluate whether rheumatoid arthritis (RA) disease activity is associated with frailty both in cross‐section and longitudinally. Methods Participants within the Veterans Affairs Rheumatoid Arthritis (VARA) registry enrolled from 2003 to 2022 were included.
Courtney N. Loecker +14 more
wiley +1 more source
The tight bond between Fanconi anemia and aging
Frontiers in AgingFanconi anemia (FA) is a rare genetic disorder characterized by genomic instability, bone marrow failure, physical abnormalities, and increased cancer susceptibility. Growing evidence suggests that.
Marco Antonio Mejía-Barrera +15 more
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Risk of retinopathy of prematurity in small for gestational age premature infants
Indian Pediatrics, 2014 To evaluate the incidence, risk factors and severity of retinopathy of prematurity in neonatal intensive care unit and to evaluate its relationship with gestational age.Cohort study of neonates with gestational age ≤ 32 weeks or birthweight ≤ 1500 g.Of the 495 neonates screened, 43 (8.7%) infants were small for gestational age; the frequency of severe ...
Bas, AHMET YAĞMUR +4 more
openaire +3 more sources
Adult Sox2+ stem cell exhaustion in mice results in cellular senescence and premature aging
Aging Cell, 2018 Aging is characterized by a gradual functional decline of tissues with age. Adult stem and progenitor cells are responsible for tissue maintenance, repair, and regeneration, but during aging, this population of cells is decreased or its activity is ...
J. Vilas +11 more
semanticscholar +1 more source