Results 161 to 170 of about 886,795 (250)

Unsupervised characterization of 100,272 EHR patients identifies high-risk groups and comorbidities linked to premature aging. [PDF]

NPJ Digit Med
Xian S, Smoller JW, Luo Y, Walunas TL, Liu C, Khan A, Weng C, Kullo IJ, Wei WQ, Jarvik GP, Crosslin DR.   +10 more
europepmc   +1 more source

Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

Advanced Science, EarlyView.
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen, Haiyang Gao, Wang Wu, Pengzhi Shi, Yuhang Chen, Anran Zhang, Zhangrong Cheng, Wenbo Wu, Zimu Yu, Yukun Zhang   +9 more
wiley   +1 more source

Assessing the Premature Aging of Chabazite in Natural Gas Drying by TSA. [PDF]

ACS Omega
Moura PAS, Rodríguez-Aguado E, Maia DAS, Cecília JA, Melo DC, Valencia S, Rey F, Bastos-Neto M, Rodríguez-Castellón E, Azevedo DCS.   +9 more
europepmc   +1 more source

Double Jeopardy Project summary of focus group results.

, 2002
Title from title screen.; Harvested from the web on 9/4/02Summarizes the results of focus groups conducted to support the "Double Jeopardy" project: supporting families in planning for a secure future for their adult children with developmental ...
Ohio.Dept. of Aging.
core  

Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment

Advanced Science, EarlyView.
After oral administration, inodorous GLU‐BA self‐assembles into nanomicelles in aqueous environments to resist premature gastric adsorption. Upon reaching the intestine, endogenous esterases rapidly cleave the built‐in ester bonds in these nanomicelles to release BA and GLU, with GLU further metabolized by gut microbiota to gradually generate BA ...
Feifei Xin, Zhike Xie, Danyue Zhao, Lin Yang, Yiqun Wan, Zuwei Liu, Situ Xiong, Ying Zhang, Lei Feng, Hao Wan   +9 more
wiley   +1 more source

Persistence of large mtDNA rearrangements linked to premature aging in Pol γ exonuclease-deficient mice. [PDF]

Nucleic Acids Res
Wu S, Lujan SA, Burkholder AB, Nissanka N, Longley MJ, Mieczkowski P, Kunkel TA, Moraes CT, Copeland WC.   +8 more
europepmc   +1 more source

Optimized Cas9‐Enriched Nanopore Sequencing and Analysis Workflow for Clinical Diagnosis of Repeat Expansion Disorders

Advanced Science, EarlyView.
An optimized Cas9‐enriched nanopore sequencing workflow, combined with STRiker, enables simultaneous analysis of disease‐associated STR loci from patient blood. The nCATS–STRiker workflow detects repeat expansions, de novo repeat motifs, interruption patterns, and methylation in a single assay, improving the genetic diagnosis of previously undiagnosed ...
Seungbok Lee, Chanju Jung, Minjeong Kim, Narae Kim, Gue‐Ho Hwang, Soon‐Tae Lee, Kon Chu, Sang Kun Lee, Han‐Joon Kim, Jong‐Hee Chae, Sangsu Bae, Jangsup Moon   +11 more
wiley   +1 more source

Effect of Thrombopoietin Receptor Agonist Romiplostim on the Ionizing Radiation-Induced Premature Aging. [PDF]

Pharmacol Res Perspect
Yamaguchi M, Hirouchi T, Sato Y, Kashiwakura I.   +3 more
europepmc   +1 more source

Interfacial Interaction‐Engineered Dual Lithiophilic Ultrathin Interlayers for Dendrite‐Suppressed Lithium Metal Textile Anodes

Advanced Science, EarlyView.
Ultrathin lithiophilic interlayers engineered on a 3D textile electrode and separator cooperatively regulate interfacial Li nucleation and Li+ transport, leading to homogeneous Li plating and mitigated dendrite formation. The resulting dual‐interfacial design provides long‐term cycling stability, improved full‐cell durability, and a scalable pathway ...
Chanseok Lee, Donghyeon Nam, Sang Hun Baeck, Boyeon Kim, Yongkwon Song, Jaemin Kim, Daegun Kim, Jun Hyuk Moon, Yoon Jang Chung, Hyeong Jun Kim, Seoin Back, Yongmin Ko, Jinhan Cho   +12 more
wiley   +1 more source

Single‐Molecule Imaging of Endogenous RNA Using a Miniaturized and Circularly Permuted CRISPR‐Cas13 Degron‐Masking System CDegSR

Advanced Science, EarlyView.
CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley   +1 more source