Results 161 to 170 of about 214,960 (327)
RecQ helicases: suppressors of tumorigenesis and premature aging [PDF]
, 2003 Csanád Z. Bachrati, Ian D. Hickson
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Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP‐43‐Associated ALS and AD
Advanced Science, EarlyView.TDP‐43 dysfunction disrupts RNA processing, inducing cryptic exon 4a1 inclusion in GAP43 and reducing its protein levels. This aberrant splicing impairs axonal regeneration and contributes to neurodegeneration in ALS and AD. RNA‐seq of patient brains reveals GAP43 downregulation and 4a1 upregulation, identifying cryptic exon 4a1 as a potential ...
Mingming Yang +9 more
wiley +1 more source
Will cloned animals suffer premature aging--the story at the end of clones' chromosomes. [PDF]
, 2003 Jie Xu, Xiangzhong Yang
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Advanced Science, EarlyView.CMT2 mediates the maintenance of DNA methylation on the promoters of SAGs, thereby inhibiting EIN3A untimely activating SAGs’ expression. Aging‐impelled striking upregulation of EIN3A strongly suppresses the expression of CMT2 to reduce the methylation level, which releases the activation of EIN3A on SAGs, thus initiating and accelerating the ...
Dingyu Zhang +10 more
wiley +1 more source
Postnatal Age at Time of Death and Incidence of Withdrawal of Intensive Care in Very Premature Neonates [PDF]
, 2003 NS Kabra, JD ARNOLD, JR Bowen
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Advanced Science, EarlyView.A highly efficient extracorporeal device for treating bacteremia is developed by integrating microfluidic bacterial margination and engineered cell‐depleted thrombi strategically constructed in the device. The rodent models, severely infected with antibiotic‐resistant bacteria, recover from bacteremia after two subsequent extracorporeal blood ...
Bong Hwan Jang +4 more
wiley +1 more source
Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG [PDF]
, 2004 Lin-Quan Sun +8 more
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Advanced Science, EarlyView.This review compares clinical outcomes, translational progress, and global funding trends across cancer phototherapies—photodynamic, photothermal, and photoimmunotherapy—and conventional immunotherapy. It highlights differences in treatment efficacy, clinical trial status, financial investment, and regulatory challenges, providing a comprehensive ...
Deepak S. Chauhan +6 more
wiley +1 more source
Advanced Pharmaceutical Nanotechnologies Applied for Chinese Herbal Medicines
Advanced Science, EarlyView.This review offers a comprehensive overview of pharmaceutical nanotechnology strategies to address limitations associated with the complex material basis and relative mild therapeutic efficacy of Chinese herbal medicines, and summarizes the advantages of these strategies.
Jiameng Li +11 more
wiley +1 more source
Gestational Age, Sex and Maternal Parity Correlate with Bone Turnover in Premature Infants [PDF]
, 2005 Hany Aly +5 more
openalex +1 more source