Mitochondrial oxidative stress, cellular damages and stem cell aging in premature aging models with complex II electron transport defect. [PDF]
Ishii T +5 more
europepmc +1 more source
Clickable Microgel Inks Enable Spatioselective, Multi‐Stimuli Programmable Assembly of Materials
Clickable microgel inks enable direct ink writing of hydrogel architectures with intrinsic spatioselective and programmable multi‐responsiveness. By combining pH‐responsive and temperature‐responsive microgel building blocks through Diels‐Alder interparticle crosslinking, the assemblies exhibit controllable swelling and shape changes.
Junho Moon +3 more
wiley +1 more source
Amelioration of premature aging in Werner syndrome stem cells by targeting SHIP/AKT pathway. [PDF]
Tam HY +8 more
europepmc +1 more source
Twin gestation and neuropsychological outcome of preschool age children born prematurely
Jamie Piercy
openalex +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
GNLY+CD8+ T cells bridge premature aging and persistent inflammation in people living with HIV. [PDF]
Wang HF +17 more
europepmc +1 more source
Antibody‐Empowered Nanomedicine for Precise Biomedical Applications
This review explores strategies for functionalizing nanoparticles with antibodies to construct antibody‐empowered nanomedicine. It discusses the classification of these nanomedicines based on antibody structure, with a specific focus on their biomedical applications in diagnostics, bioimaging, and therapeutics for various diseases.
Chen Chen +7 more
wiley +1 more source
Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo +5 more
wiley +1 more source

