Results 191 to 200 of about 214,960 (327)

SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy

Advanced Science, EarlyView.
During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong, Guangyu Liang, Huimin Yu, Jiaqi Li, Ruohong Wang, Xiaohong Ma, Ziqing Zhou, Yin Zhao, Fei Sun, Xufang Sun   +9 more
wiley   +1 more source

Smoking and Risk of Premature Death among Middle‐aged Japanese: Ten‐year Follow‐up of the Japan Public Health Center‐based Prospective Study on Cancer and Cardiovascular Diseases (JPHC Study) Cohort I

, 2002
Megumi Hara, Tomotaka Sobue, Satoshi Sasaki, Shoichiro Tsugane   +3 more
openalex   +1 more source

Overexpression of Neprilysin Reduces Alzheimer Amyloid-β42 (Aβ42)-induced Neuron Loss and Intraneuronal Aβ42 Deposits but Causes a Reduction in cAMP-responsive Element-binding Protein-mediated Transcription, Age-dependent Axon Pathology, and Premature Death in Drosophila [PDF]

, 2008
Kanae Iijima‐Ando, Stephen Hearn, Linda Granger, Christopher Shenton, Anthony Gatt, Hsueh‐Cheng Chiang, Inessa Hakker, Yi Zhong, Koichi Iijima   +8 more
openalex   +1 more source

Akkermansia Muciniphila Alleviates Severe Acute Pancreatitis via Amuc1409‐Ube2k‐Foxp3 Axis in Regulatory T Cells

Advanced Science, EarlyView.
Akkermansia depletion correlates with acute pancreatitis (AP) severity. A. muciniphila and its protein Amuc_1409 mitigate pancreatic/systemic inflammation by expanding Tregs and IL‐10. Mechanistically, Amuc_1409 binds Ube2k, inhibiting Foxp3 ubiquitination to stabilize Treg differentiation and IL‐10 production, countering SAP‐induced SIRS/CARS ...
Jinyan Xie, Lijun Du, Yunkun Lu, Xiuliu Guo, Xinyuan Zhou, Yifan Tong, Bo Shen, Xin Yu, Feng Guo, Hong Yu   +9 more
wiley   +1 more source

Prevalence of atherogenic LDL pattern B in asymptomatic middle aged African Americans with a family history of premature coronary heart diseases

, 2002
Khurram Nasir, Diane M. Becker, Lisa R. Yanek, Taryn F. Moy, Lewis C. Becker, Roger S. Blumenthal   +5 more
openalex   +1 more source

Intensive Care for Extreme Prematurity — Moving beyond Gestational Age [PDF]

, 2008
Jon E. Tyson, Nehal A. Parikh, John Langer, Charles Green, Rosemary D. Higgins   +4 more
openalex   +1 more source

Dual‐Modular Hydrogel Microparticles with Precision‐Modulation of Inflammatory Microenvironment Dictate Full‐Thickness Cartilage Regeneration for Osteoarthritis Repair

Advanced Science, EarlyView.
Cartilage injury is a prominent pathological hallmark of osteoarthritis. In this study, we developed a two‐modular hydrogel microparticle system wherein HMP‐A effectively targets the damaged area, while HMP‐B forms an efficient connection with HMP‐A on the cartilage surface.
Xinye Chen, Yuanman Yu, Zirui He, Lina Pan, Jing Wang, Changsheng Liu   +5 more
wiley   +1 more source

Bi‐Functional Diaminopropane Additive Enables Stable Li Anodes and Highly Efficient Cathodes for High‐Performance Li‐Air Batteries

Advanced Science, EarlyView.
Diaminopropane (DAP) solvent is employed as a bi‐functional additive for Li‐air batteries. It spontaneously reacts to form a gel layer to prevent corrosion on the Li anode and maintain a liquid state at the cathode to improve the decomposition of Li2O2.
Honghao Hu, Qingxu Zhang, Jiucong Liu, Junjie Li, Pingli Wu, Caicai Li, Peipei Du, Huiqiao Li, Xizheng Liu   +8 more
wiley   +1 more source

Mechanistic insights into cadmium-related premature aging in <i>Drosophila</i> model. [PDF]

Front Neurosci
De Donno MD, Mercuri E, Balena B, Zangaro F, Bozzetti MP, Specchia V.   +5 more
europepmc   +1 more source

A gestation- and postnatal age-based reference chart for assessing renal function in extremely premature infants [PDF]

, 2008
Sudhin Thayyil, Shahila Sheik, Stephen Kempley, Ajay Sinha   +3 more
openalex   +1 more source