Results 211 to 220 of about 241,214 (349)

Corrigendum to “Predicting all-cause mortality and premature death using interpretable machine learning among a middle-aged and elderly Chinese population” [Heliyon Volume 10, Issue 17, September 15 2024, Article e36878]

Qi Yu, Lingzhi Zhang, Qian Ma, Lijuan Da, Jiahui Li, Wenyuan Li   +5 more
openalex   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Functional Impact Score of Mitochondrial Variants and Its Relationship With Functional Connectivity of the Brain: Potential Origins of Premature Aging in Young Adulthood. [PDF]

Hum Brain Mapp
Mareckova K, Mendes-Silva AP, Mareček R, Jordánek T, Pačínková A, Klánová J, Gonçalves VF, Nikolova YS.   +7 more
europepmc   +1 more source

Mild Focal Cooling Decouples Dendrites to Reconfigure Cortical Output

Advanced Science, EarlyView.
Mild cooling of the cortical surface selectively modulates apical dendritic excitability, plasticity, and somato‐dendritic coupling, while uncoupling these effects from basal dendrites, and reshapes apical‐driven responses in barrel cortex during whisker touch.
Meisam Habibi Matin, Shulan Xiao, Krishna Jayant   +2 more
wiley   +1 more source

Mechanistic insights into cadmium-related premature aging in <i>Drosophila</i> model. [PDF]

Front Neurosci
De Donno MD, Mercuri E, Balena B, Zangaro F, Bozzetti MP, Specchia V.   +5 more
europepmc   +1 more source

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

Advanced Science, EarlyView.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang, Wenzhi Wang, Dongjiao Wang, Qibin Wu, Youxiong Que   +4 more
wiley   +1 more source

Mitochondrial Respiratory Dysfunction Is Not Correlated With Mitochondrial Genotype in Premature Aging Mice. [PDF]

Aging Cell
Tamashiro H, Ishikawa K, Sadotomo K, Ogasawara E, Nakada K.   +4 more
europepmc   +1 more source

Natural Variation of NAR5 Determines Nitrogenase Activity and the Yield in Soybean

Advanced Science, EarlyView.
This study identified NAR5, a gene encoding a subtilisin‐like protease, that regulates nitrogenase activity in soybean nodules. Overexpressing NAR5 delayed nodule senescence, enhancing nitrogenase activity, yield, and low‐nitrogen tolerance. The elite haplotype NAR5HapI‐1 linked to superior nitrogenase activity and greater seed weight has been ...
Chao Ma, Hanyu Zhao, Haojie Feng, Xulun Dong, Lin Chen, Mingliang Yang, Runyi Chen, Chengjun Lei, Chunyan Liu, Qingshan Chen, Dawei Xin, Jinhui Wang   +11 more
wiley   +1 more source

Age- and sex-specific deterioration on bone and osteocyte lacuno-canalicular network in a mouse model of premature aging. [PDF]

Bone Res
Yılmaz D, Marques FC, Gregorio L, Schlatter J, Gehre C, Pararajasingam T, Qiu W, Mathavan N, Qin XH, Wehrle E, Kuhn GA, Müller R.   +11 more
europepmc   +2 more sources

Neonatal multimorbidity and the phenotype of premature aging in preterm infants. [PDF]

Pediatr Res
Litt JS, Belfort MB, Everson TM, Haneuse S, Tiemeier H.   +4 more
europepmc   +1 more source