Results 211 to 220 of about 886,795 (250)

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

Age- and sex-specific deterioration on bone and osteocyte lacuno-canalicular network in a mouse model of premature aging. [PDF]

Bone Res
Yılmaz D, Marques FC, Gregorio L, Schlatter J, Gehre C, Pararajasingam T, Qiu W, Mathavan N, Qin XH, Wehrle E, Kuhn GA, Müller R.   +11 more
europepmc   +1 more source

Oral Astilbin Nanogels Modulate Senescence‐Associated CD4+ T Cells and Promote Treg Induction in Aged Mice with Colitis

Advanced Science, EarlyView.
Fluorinated β‐glucan/pectin nanogels enable colon‐targeted oral delivery of astilbin through gastrointestinal protection, β‐glucanase‐responsive release, mucus penetration, and prolonged retention. The released astilbin attenuates senescence‐associated features of CD4+ T cells and promotes Treg responses, while the nanogel matrix modulates the gut ...
Lei Zhao, Xinyun Zhang, Qian Ren, Xue Song, Meifang Zhao, Rongshen Wang, Haocheng Du, Yan Chen, Peigen Xu, Jiangyun Liu, Jian Zhang, Jingjing Ma   +11 more
wiley   +1 more source

Loss of H3K9 trimethylation leads to premature aging

Ocampo A, Mrabti C, Yang N, Desdín-Micó G, Alonso-Calleja A, Vílchez-Acosta A, Pico S, Parras A, Piao Y, Schoenfeldt L, Luo S, Haghani A, Brooke RT, Maza MdC, Branchina C, Maroun CY, von Meyenn F, Naveiras O, Horvath S, Sen P, Bignon Y.   +20 more
europepmc   +2 more sources

Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation

Advanced Science, EarlyView.
Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir, Yagmur Ozendi, Gokhan Burcin Kubat, Keshav K. Singh   +3 more
wiley   +1 more source

GNLY+CD8+ T cells bridge premature aging and persistent inflammation in people living with HIV. [PDF]

Emerg Microbes Infect
Wang HF, Zhang C, Zhang LP, Zhen C, Zhao L, Huang HH, Yang BP, Chen SY, Li WZ, Zhou MJ, Guo QX, Li X, Yin BL, Sun F, Zhang JY, Zhang Z, Wang FS, Zeng QL.   +17 more
europepmc   +1 more source

Nanoscale Buried Interface Control in Silicone Hydrogels Enables a Biointerface Engineering Platform

Advanced Science, EarlyView.
A hydrophilic coating with controllable nanoscale thickness is applied to commercial silicone hydrogel contact lenses. By combining comprehensive multi‐modal three‐dimensional characterization with an advanced algorithm, the thickness and chemical information of these multilayered structures are resolved.
Po‐Hsiang Chen, Jia‐Hua Wang, Ching Chen, Shih‐Hsuan Fu, Rajan Deepan Chakravarthy, Hsin‐Chieh Lin   +5 more
wiley   +1 more source

Mitochondrial oxidative stress, cellular damages and stem cell aging in premature aging models with complex II electron transport defect. [PDF]

J Clin Biochem Nutr
Ishii T, Yasuda K, Miyazawa M, Onouchi H, Yanase S, Ishii N.   +5 more
europepmc   +1 more source

Porphyrin‐Based Porous Materials for Antibacterial Applications

Advanced Science, EarlyView.
Porphyrin‐based porous materials have excellent photophysical properties and tunable structures for high‐efficiency antibacterial therapy. This review comprehensively discusses the structural design strategies and synthetic pathways of the four main types of porphyrin‐based porous materials, summarizes their cross‐domain antimicrobial applications, and
Xiao‐Xue Liang, Xin Li, Ying Xiong, Xin Wang, Ying‐Wei Yang   +4 more
wiley   +1 more source

PML Nuclear Bodies and Cellular Senescence: A Comparative Study of Healthy and Premature Aging Syndrome Donors' Cells. [PDF]

Cells
Smirnov EY, Silonov SA, Shmidt EA, Nozdracheva AV, Pleskach NM, Kuranova ML, Gavrilova AA, Romanovich AE, Kuznetsova IM, Turoverov KK, Fonin AV.   +10 more
europepmc   +1 more source