Results 221 to 230 of about 241,214 (349)

Bifunctional Artificial Enzymes‐Loaded Microgels With LOX‐ and CAT‐Like Activities for Metabolic Reprogramming and Scarless Wound Repair

Advanced Science, EarlyView.
A bifunctional lactate oxidase‐like and catalase‐like artificial enzyme (Metazyme) is integrated into a rod‐shaped microgel (MetaRgel) to enable cascade lactate oxidation and oxygen regeneration. By reprogramming the wound metabolic microenvironment, MetaRgel alleviates excessive lactate accumulation, oxidative stress, hypoxia, and inflammation ...
Yongyuan Kang, Pai Peng, Liang Song, Qiaoxuan Wang, Zilong Zhong, Dongchao Qiu, Yunfan Liu, Kefei Zhao, Xiaofei Dong, Changyou Gao   +9 more
wiley   +1 more source

Generalized neuromuscular hypoplasia, reduced smooth muscle myosin and altered gut motility in the klotho model of premature aging

, 2011
David T. Asuzu, Yujiro Hayashi, F Izbéki, Laura Popko, David Young, Michael R. Bardsley, Attila T. Lörincz, Makoto Kuro‐o, David R. Linden, Gianrico Farrugia, T. Ordog   +10 more
openalex   +2 more sources

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, EarlyView.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source

Nutritional and Hormonal Status of Premature Infants Born with Intrauterine Growth Restriction at the Term Corrected Age

, 2016
I. А. Belyaeva, Leyla S. Namazova-Baranova, Еlena P. Bombardirova, M. V. Okuneva   +3 more
openalex   +2 more sources

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Restoring neuropetide Y levels in the hypothalamus ameliorates premature aging phenotype in mice. [PDF]

Geroscience
Ferreira-Marques M, Carmo-Silva S, Pereira J, Botelho M, Nóbrega C, López-Otín C, de Almeida LP, Aveleira CA, Cavadas C.   +8 more
europepmc   +1 more source

Premature Birth and Large for Gestational Age Are Associated with Risk of Barrett’s Esophagus in Adults

, 2015
Seiji Shiota, Hashem B. El‐Serag, Aaron P. Thrift   +2 more
openalex   +2 more sources

Microstructure‐Resolved Modeling to Predicting and Regulating Lithium Plating‐Stripping Dynamics on Graphite Electrodes

Advanced Science, EarlyView.
ABSTRACT The lithium plating reaction in graphite electrodes acts as a root cause for the accelerated degradation and the internal short circuits in lithium‐ion batteries. Here, an electrochemical model based on multi‐scale microstructural images was established to identify lithium plating‐stripping processes, thereby supporting the predictive outcomes
Heng Huang, Yang Li, Xinyu Liu, Zhifu Zhou, Wei‐Tao Wu, Lei Wei, Chengzhi Hu, Linsong Gao, Yubai Li, Yongchen Song   +9 more
wiley   +1 more source

Premature aging of red wines: a matter of fatty acid oxidation? A review on lipid-derived molecular markers and their possible precursors. [PDF]

J Sci Food Agric
Prezioso I, Ottaviano E, Corcione G, Digiorgio C, Fioschi G, Paradiso VM.   +5 more
europepmc   +1 more source

Stable Diffusion Models Reveal a Persisting Human–AI Gap in Visual Creativity

Advanced Science, EarlyView.
This study examines visual creativity in humans and generative AI using the TCIA framework. Human artists outperform AI overall, yet structured human guidance substantially improves AI outputs and evaluations. Findings reveal that alignment with human creativity depends critically on contextual framing, highlighting both the promise and current ...
Silvia Rondini, Claudia Alvarez‐Martin, Paula Angermair‐Barkai, Olivier Penacchio, Marc Paz, Matthew Pelowski, Dan Dediu, Antoni Rodriguez‐Fornells, Xim Cerda‐Company   +8 more
wiley   +1 more source