Results 221 to 230 of about 886,795 (250)

Low‐Density Lipoprotein Receptor‐Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption

Advanced Science, EarlyView.
A low‐density lipoprotein receptor‐oriented biomimetic nanoplatform couples brain‐tumor delivery with a mechanistically matched regorafenib‐erythrodiol combination. Concurrent disruption of autophagic nutrient salvage and cholesterol homeostasis collapses bioenergetic and signaling support, suppresses glioblastoma stemness, and promotes immunogenic ...
Yining Jiang, Wenzhuo Yang, Wenting Cheng, Jing Zuo, Lin Pan, Sheng Zhong, Ren Geng, Yao Zhao, Zijian Chen, Canhua Huang, Yang Bai, Liyan Zhao, Yunqian Li   +12 more
wiley   +1 more source

IgG1 glycosylation highlights premature aging in Down syndrome. [PDF]

Aging Cell
Streng BMM, Van Coillie J, Wildenbeest JG, Binnendijk RS, Smits G, den Hartog G, Wang W, Nouta J, Linty F, Visser R, Wuhrer M, Vidarsson G, Bont LJ, PRIDE study group.   +13 more
europepmc   +1 more source

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

A Biomimetic cRGDyk‐Engineered Platelet Nanoplatform for ACAD11 Delivery to Trigger Pyroptosis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A biomimetic platelet nanoplatform (OE‐ACAD11@R‐PLT) is developed for targeted hepatocellular carcinoma immunotherapy. By selectively delivering therapeutic plasmids, this system induces mitochondrial dysfunction and triggers robust NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis in tumor cells.
Hongyi Bao, Wei Feng, Wei Zong, Yi Li, Xinyue Qin, Xinyue Wang, Yubo Yang, Guanhua Chen, Yiting Hou, Xuan Tan, Lin Chen, Ming Zhang, Feng Wang   +12 more
wiley   +1 more source

What Is the Impact of Obesity-Related Comorbidities on the Risk of Premature Aging in Patients with Severe Obesity?: A Cross-Sectional Study. [PDF]

Medicina (Kaunas)
Dudek A, Zapała B, Gorostowicz A, Kawa I, Ciszek K, Tylec P, Cyranka K, Sierocki W, Wysocki M, Major P.   +9 more
europepmc   +1 more source

Mechanochemical Engineered Sulfur Copolymers Onto Group 13 and Related Fillers Through Lewis Acid‐Base Pairing

Advanced Science, EarlyView.
Green mechanochemical copolymerization was developed for universal interfacial modification of Group 13 and related fillers. By leveraging Lewis acid–base coordination to anchor sulfur‐containing polymers—validated via multiscale characterization and DFT—this versatile method boosts performance across liquid fuels, thermal‐shielding materials, and ...
Chen Wang, Xiaoyang Shao, Zixuan Lei, Ruoqing Zhao, Xiaozhong Bao, Shuiping Zhou, Wen Ao, Zhenhua Wang   +7 more
wiley   +1 more source

Drosophila Topoisomerase 3β binds to mRNAs in vivo, contributes to their localization and stability, and counteracts premature aging. [PDF]

PLoS One
Teimuri S, Suter B.
europepmc   +1 more source

Physiological premature aging of ovarian blood vessels leads to decline in fertility in middle-aged mice. [PDF]

Nat Commun
Mu L, Wang G, Yang X, Liang J, Tong H, Li L, Geng K, Bo Y, Hu X, Yang R, Xu X, Zhang Y, Zhang H.   +12 more
europepmc   +1 more source

Corrigendum: Correction of Figure. High Cardiorespiratory Fitness Protects against Molecular Impairments of Metabolism, Heart, and Brain with Higher Efficacy in Obesity-Induced Premature Aging. [PDF]

Endocrinol Metab (Seoul)
Pantiya P, Thonusin C, Sumneang N, Ongnok B, Chunchai T, Kerdphoo S, Jaiwongkam T, Arunsak B, Siri-Angkul N, Sriwichaiin S, Chattipakorn N, Chattipakorn SC.   +11 more
europepmc   +1 more source

Skewed epithelial cell differentiation and premature aging of the thymus in the absence of vitamin D signaling. [PDF]

Sci Adv
Artusa P, Nguyen Yamamoto L, Barbier C, Valbon SF, Aghazadeh Habashi Y, Djambazian H, Ismailova A, Lebel MÈ, Salehi-Tabar R, Sarmadi F, Ragoussis J, Goltzman D, Melichar HJ, White JH.   +13 more
europepmc   +1 more source