Results 241 to 250 of about 9,691,387 (324)

Hierarchical Ordering Induced Ultrahigh Cryogenic Strength and Strain Hardening in a Ni2CoFeV Medium‐Entropy Alloy

Advanced Science, EarlyView.
A tri‐phase Ni2CoFeV medium‐entropy alloy with fcc, κ, and L12 phases achieves exceptional cryogenic strength‐ductility synergy at 77 K. It delivers a yield strength of 1.4 GPa, an ultimate tensile strength of 2.07 GPa and a tensile ductility of 28%.
Lei Gu, Wei Jiang, Qingzhong Mao, Xiang Chen, Yonghao Zhao   +4 more
wiley   +1 more source

Mixed‐Coordination Electrolytes With Molecular Additives for Robust Interphases in High‐Voltage Rechargeable Magnesium Batteries

Advanced Science, EarlyView.
A mixed‐coordination electrolyte (MCE) combined with a molecular additive (MCE‐MA) promotes pseudo ion pair (pIP) formation within a solvent‐separated ion pair (SSIP)–rich environment, enabling a robust interphase that significantly improves the cycle performance of high‐voltage rechargeable magnesium batteries (RMBs).
Dedy Setiawan, Toshihiko Mandai
wiley   +1 more source

Amelioration of premature aging in Werner syndrome stem cells by targeting SHIP/AKT pathway. [PDF]

Cell Biosci
Tam HY, Liu J, Yiu TC, Leung AO, Li C, Gu S, Rennert O, Huang B, Cheung HH.   +8 more
europepmc   +1 more source

Dysfunction of the MDM2/p53 axis is linked to premature aging.

Journal of Clinical Investigation, 2017
D. Lessel, Danyi Wu, C. Trujillo, T. Ramezani, Ivana Lessel, M. K. Alwasiyah, Bidisha Saha, F. Hisama, Katrin Rading, I. Goebel, P. Schütz, G. Speit, J. Högel, H. Thiele, G. Nürnberg, P. Nürnberg, M. Hammerschmidt, Yan Zhu, David R. Tong, C. Katz, G. Martin, J. Oshima, C. Prives, C. Kubisch   +23 more
semanticscholar   +1 more source

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

Loss of H3K9 trimethylation leads to premature aging

Ocampo A, Mrabti C, Yang N, Desdín-Micó G, Alonso-Calleja A, Vílchez-Acosta A, Pico S, Parras A, Piao Y, Schoenfeldt L, Luo S, Haghani A, Brooke RT, Maza MdC, Branchina C, Maroun CY, von Meyenn F, Naveiras O, Horvath S, Sen P, Bignon Y.   +20 more
europepmc   +2 more sources

Mitochondrial oxidative stress, cellular damages and stem cell aging in premature aging models with complex II electron transport defect. [PDF]

J Clin Biochem Nutr
Ishii T, Yasuda K, Miyazawa M, Onouchi H, Yanase S, Ishii N.   +5 more
europepmc   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source