Results 231 to 240 of about 9,691,387 (324)

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source

Faster and Durable: A Cell‐to‐System Validation of a Low‐Degradation Fast‐Charge Protocol for Li‐Ion Batteries

Advanced Science, EarlyView.
A physics‐based framework resolving graphite phase‐separation dynamics establishes a predictive, degradation‐aware fast‐charging methodology for commercial Li‐ion batteries. The resulting model‐informed protocol achieves 20%–80% state‐of‐charge in 14 min while matching the long‐term degradation of a commercial 25‐minute EV strategy.
Marco Lagnoni, Francesco Giuseppe Quilici, Davide Cademartori, Claudio Scarpelli, Uways Nurulain Mithoowani, Federica Barontini, Alessandro Ruvio, Monica Puccini, Giovanni Lutzemberger, Maria Paola Carpanese, Antonio Bertei   +10 more
wiley   +1 more source

Restoring neuropetide Y levels in the hypothalamus ameliorates premature aging phenotype in mice. [PDF]

Geroscience
Ferreira-Marques M, Carmo-Silva S, Pereira J, Botelho M, Nóbrega C, López-Otín C, de Almeida LP, Aveleira CA, Cavadas C.   +8 more
europepmc   +1 more source

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

rDNA Copy Number Variation and Methylation During Normal and Premature Aging. [PDF]

Aging Cell
Geisen ABC, Santana Acevedo N, Oshima J, Dittrich M, Potabattula R, Haaf T.   +5 more
europepmc   +1 more source

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

Correction to: Chemical screen identifies a geroprotective role of quercetin in premature aging. [PDF]

Protein Cell
europepmc   +1 more source

Premature aging of red wines: a matter of fatty acid oxidation? A review on lipid-derived molecular markers and their possible precursors. [PDF]

J Sci Food Agric
Prezioso I, Ottaviano E, Corcione G, Digiorgio C, Fioschi G, Paradiso VM.   +5 more
europepmc   +1 more source

Precipitation‐Modulated Harmonic Architectures Enable Superior Strength–Ductility Synergy from Cryogenic to Elevated Temperatures in Nanostructured Alloys

Advanced Science, EarlyView.
Precipitation‐modulated recrystallization enables a programmable bimodal harmonic architecture in a high‐entropy alloy, delivering 1–2 GPa yield strength with >10% ductility from −196 °C to 700 °C. The resulting broad‐temperature robustness arises from the synergy of dual‐mode nanoprecipitation, harmonic core–shell topology, and temperature‐adaptive ...
Wei Li, Liangyin Xiong, Mengchao Niu, Junhua Luan, Wei Wang, Zengbao Jiao   +5 more
wiley   +1 more source

CRISPR-engineered human GATA2 deficiency model uncovers mitotic dysfunction and premature aging in HSPCs, impairing hematopoietic fitness. [PDF]

Leukemia
Romero-Moya D, Torralba-Sales E, Calvo C, Marin-Bejar O, Magallon-Mosella M, Distefano M, Pera J, Castaño J, De Giorgio F, Gonzalez J, Iglesias A, Berenguer-Balaguer C, Schilling M, Plass M, Pasquali L, Català A, Molina O, Wlodarski MW, Bigas A, Giorgetti A.   +19 more
europepmc   +1 more source