Results 231 to 240 of about 241,214 (349)

Correction to: Chemical screen identifies a geroprotective role of quercetin in premature aging. [PDF]

Protein Cell
europepmc   +1 more source

CRISPR-engineered human GATA2 deficiency model uncovers mitotic dysfunction and premature aging in HSPCs, impairing hematopoietic fitness. [PDF]

Leukemia
Romero-Moya D, Torralba-Sales E, Calvo C, Marin-Bejar O, Magallon-Mosella M, Distefano M, Pera J, Castaño J, De Giorgio F, Gonzalez J, Iglesias A, Berenguer-Balaguer C, Schilling M, Plass M, Pasquali L, Català A, Molina O, Wlodarski MW, Bigas A, Giorgetti A.   +19 more
europepmc   +1 more source

Discovering Interpretable Semantics from Radio Signals for Contactless Cardiac Monitoring

Advanced Science, EarlyView.
This study presents a semantic representation framework for clinically interpretable cardiac monitoring from contactless radio signals. It formulates radio semantic learning as an information‐bottleneck problem and approximates the objective via intra‐modal compression and cross‐modal alignment, structuring radio measurements into meaningful semantic ...
Jinbo Chen, Haoyu Wang, Guixin Xu, Yuqin Yuan, Xinmeng Cai, Zhengwu Wei, Dongheng Zhang, Qibin Sun, Tianwei Zhang, Cuntai Guan, Yan Chen   +10 more
wiley   +1 more source

rDNA Copy Number Variation and Methylation During Normal and Premature Aging. [PDF]

Aging Cell
Geisen ABC, Santana Acevedo N, Oshima J, Dittrich M, Potabattula R, Haaf T.   +5 more
europepmc   +1 more source

Reduced <i>ech-6</i> Expression Attenuates Fat-Induced Premature Aging in <i>C. Elegans</i>

, 2020
Yasmine J. Liu, Arwen W. Gao, Reuben L. Smith, Georges E. Janssens, Daan M. Panneman, Aldo Jongejan, Michel van Weeghel, Frédéric M. Vaz, Melissa J. Silvestrini, Louis R. Lapierre, Alyson W. MacInnes, Riekelt H. Houtkooper   +11 more
openalex   +1 more source

High‐Throughput Data Generation and Transfer Learning Enabled Microstructure‐Property Integrated Design of Nickel‐Based Powder Metallurgy Superalloy

Advanced Science, EarlyView.
An integrated transfer learning framework integrates CALPHAD simulations, diffusion‐multiple experiments, and literature data to predict long‐term microstructural stability and short‐term mechanical properties of Ni‐based powder metallurgy superalloys. Based on these model predictions, a high‐performance, low‐density alloy, USTB‐PM750, is designed from
Zixin Li, Hongtao Zhang, Zichao Peng, Yuheng Zhang, Qian Lv, Yihuan Cao, Xuqing Wang, Huadong Fu, Jianxin Xie   +8 more
wiley   +1 more source

Senomorphic Small Extracellular Vesicles Delivered by a Tissue‐Adhesive α‐Lipoic‐Acid Hydrogel Enable Immuno‐Rejuvenation for Bone‐Tendon Interface Regeneration

Advanced Science, EarlyView.
This work identifies M1 macrophage‐mediated inflammation as a key driver of BMSC senescence and bone microstructural deterioration at the enthesis. A tissue‐adhesive hydrogel delivering senomorphic small extracellular vesicles suppresses this inflammatory‐senescent cascade and enhances BMSC resilience by inhibiting the cGAS‐STING‐NF‐κB pathway.
Lingzhi Kong, Wei Song, Wencai Liu, Hui Xu, Yuhao Yu, Xinyue Yang, Haiyan Li, Yanlun Zhu, Yaohua He   +8 more
wiley   +1 more source

Amelioration of premature aging in Werner syndrome stem cells by targeting SHIP/AKT pathway. [PDF]

Cell Biosci
Tam HY, Liu J, Yiu TC, Leung AO, Li C, Gu S, Rennert O, Huang B, Cheung HH.   +8 more
europepmc   +1 more source

Robust and Thermally Stable Silicone Aerogels with Hyperconnected Network via Kinetically Optimized Hyperbranched Silane Precursors

Advanced Science, EarlyView.
Reactivity‐Programmed Assembly: A kinetic‐control strategy is reported for constructing hyperconnected silicone aerogels with a robust “thick‐neck” architecture. By exploiting the reactivity disparity of precursors, flexible segments are uniformly embedded within a rigid skeleton.
Aoqing Yan, Guixiang Li, Yaolan Li, Yi Luo, Bin Liu, Zhe Su, Hao Tian, Wei Shi, Bo Niu, Donghui Long   +9 more
wiley   +1 more source

Loss of H3K9 trimethylation leads to premature aging

Ocampo A, Mrabti C, Yang N, Desdín-Micó G, Alonso-Calleja A, Vílchez-Acosta A, Pico S, Parras A, Piao Y, Schoenfeldt L, Luo S, Haghani A, Brooke RT, Maza MdC, Branchina C, Maroun CY, von Meyenn F, Naveiras O, Horvath S, Sen P, Bignon Y.   +20 more
europepmc   +2 more sources