Background: Premature luteinizing hormone (LH) surge is one of the causes for assisted reproductive technology cycle cancellation, and it is needed to find novel approaches with improved efficacy and safety profile.
Niloofar Motaref +6 more
doaj +1 more source
Dose-finding study of daily GnRH antagonist for the prevention of premature LH surges in IVF/ICSI patients: optimal changes in LH and progesterone for clinical pregnancy [PDF]
An optimal range of LH concentrations for achieving pregnancy has not been established. The aim of this study was to investigate the effect of various LH levels induced by different GnRH antagonist doses on IVF outcome.This was a prospective, single centre study including 144 IVF patients, stimulated with recombinant FSH from cycle day 2, and co ...
Huirne, J.A.F. +7 more
openaire +2 more sources
Identification of the LH surge by measuring intact and total immunoreactivity in urine for prediction of ovulation time [PDF]
Objectives In our earlier study, we separated three different molecular forms of urinary LH-ir (U-LH-ir) by gel filtration and identified them by immunoassay in urine from regularly menstruating women on periovulatory days.
Tapanainen, Juha S. +11 more
core +1 more source
Effect of cetrorelix dose on premature LH surge during ovarian stimulation
Previous studies have shown that ovarian stimulation with clomiphene citrate (CC), human menopausal gonadotrophin (HMG), and multiple-dose gonadotrophin-releasing hormone (GnRH) antagonist is associated with a high rate of premature LH surge. This study assessed whether administration of the GnRH antagonist cetrorelix at an incremental dose or at a ...
Y H, Lin +6 more
openaire +2 more sources
New protocol for commencing the GnRH antagonist in assisted conception treatment cycles: elimination of the premature LH surge with similar pregnancy rates [PDF]
GnRH antagonists have been used with increasing frequency in assisted reproduction treatments over the past few years and have been associated with quicker and more profound LH suppression and shorter treatment cycles than conventional GnRH agonists.
Mavrides, Andreas +2 more
openaire +2 more sources
Study of Positive and Negative Consequences of Using GnRH Antagonist in Intrauterine Insemination Cycles [PDF]
Background To assess the usefulness of premature luteinization hormone (LH) surge prevention in an intrauterine insemination (IUI) cycle by GnRH antagonist administration Materials and methods Sixty patients with unexplained or mild male infertility or
Shirin Ghazizadeh +4 more
doaj +1 more source
Gonadotropin releasing hormone analogs as part of controlled ovarian stimulation
I describe how we identified the need to block the luteinizing hormone (LH) surge when trying to control the processes of luteinization and ovulation within the clinic.
Richard Fleming, Ph.D.
doaj +1 more source
Progesterone can block estrogen-induced luteinising hormone (LH) surge secretion and can be used clinically to prevent premature LH surges. The blocking effect of progesterone on the LH surge is mediated through its receptor in the anteroventral ...
Chen, Qiuju +12 more
core +1 more source
ObjectiveTo explore the cycle characteristics and pregnancy outcomes of progestin-primed ovarian stimulation (PPOS) using fixed versus degressive doses of medroxyprogesterone acetate (MPA) in conjunction with letrozole (LE) in infertile women by ...
Ying Zhang +45 more
doaj +1 more source
The endocrine effects of multiple folliculogenesis
Induction of multiple follicular development is a common practice in IVF programmes. Nevertheless, such an approach is not without implications. Apart from the high multiple pregnancy rate, marked changes in the secretion of pituitary and ovarian ...
Ioannis E. Messinis
doaj +1 more source

