Results 81 to 90 of about 665,097 (197)

Preclinical and Toxicology Studies of LPM7100328, a Novel Oral GnRH Antagonist

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT LPM7100328 is a novel oral GnRH antagonist being developed for the prevention of premature luteinizing hormone (LH) surges in women undergoing controlled ovarian stimulation. The studies presented herein reported assessment of safety in favor of human clinical trials.
Yao Wang, Junxian Zhao, Fangxia Zou, Wanglin Jiang, Jianzhao Zhang, Pengfei Yu, Liang Ye, Xiaolin Sun, Chunmei Li, Jingwei Tian   +9 more
wiley   +1 more source

Comparable clinical outcome using the GnRH antagonist ganirelix or a long protocol of the GnRH agonist triptorelin for the prevention of premature LH surges in women undergoing ovarian stimulation [PDF]

Human Reproduction, 2001
This multicentre, randomized study was performed to assess the efficacy and safety of 0.25 mg ganirelix (Orgalutran, Antagon) treatment, using triptorelin (Decapeptyl) in a long protocol as a reference treatment. In total, 236 subjects were randomized to treatment with ganirelix (0.25 mg, s.c.) and 119 to triptorelin (0.1 mg, s.c.) treatment (treatment
openaire   +2 more sources

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu, Hao Li, Ching Kang, Dongling Guo, Shuyu Liu, Jiaqi Meng, Zhiqian Huang, Yu Du, Xiangjia Zhu   +8 more
wiley   +1 more source

Corticosterone Blocks Ovarian Cyclicity and the LH Surge via Decreased Kisspeptin Neuron Activation in Female Mice [PDF]

, 2016
Stress elicits activation of the hypothalamic-pituitary-adrenal axis, which leads to enhanced circulating glucocorticoids, as well as impaired gonadotropin secretion and ovarian cyclicity.
Chaing, Sharon, Luo, Elena, Munaganuru, Nagambika, Stephens, Shannon BZ, Kauffman, Alexander S, Breen, Kellie M, Stephens, Shannon B Z   +6 more
core   +2 more sources

Impact of Hibiscus sabdariffa Incorporation on Physicochemical Properties, Color Attributes, and Antioxidant Activity of Mead

Journal of Food Science, Volume 91, Issue 9, September 2026.
ABSTRACT The incorporation of botanical ingredients into mead has emerged as a promising strategy for developing fermented beverages enriched with natural bioactive compounds with improved physicochemical quality and bioactive properties. This study evaluated the fermentation performance of mead production and the effects of post‐fermentation ...
Luiz Antônio Teixeira Pedott, Lucas Henrique do Nascimento, Laís Thomazoni, Jamile Zeni, Eunice Valduga   +4 more
wiley   +1 more source

Characteristics of the LH surge in the animals selected for study.

, 2016
Characteristics of the LH surge in the animals selected for study.
Rex J. Scaramuzzi (3158751), Lionel Lardic (3158742), Joëlle Dupont (89742), Stéphanie Martinet (3158739), Claude Fabre-Nys (3158745), Audrey Chanvallon (3158748), Didier Lomet (1613275)   +6 more
core   +1 more source

Premature luteinization is not eliminated by pituitary desensitization with leuprolide acetate in women undergoing gonadotrophin stimulation who demonstrated premature luteinization in a prior gonadotrophin-only cycle.

, 1993
A total of 40 women who demonstrated premature luteinization (serum progesterone \u3e or = 3.5 nmol/l (1.1 ng/ml) on or before the day of human chorionic gonadotrophin (HCG) administration) during ovarian stimulation with human menopausal gonadotrophins (
Guzman, I, Hofmann, G E, Bergh, P A, Masuku, S, Navot, D   +4 more
core   +1 more source

Multi‐Stimuli‐Responsive Hydrogen‐Bonded Organic Frameworks Nanocarriers Enable Targeted Fungicide Release and Plant Immune Regulation

Advanced Science, Volume 13, Issue 48, 28 August 2026.
A fluorinated hydrogen‐bonded organic framework nanocarrier (PFC‐1‐F) loaded with PYR and coated with HACC enables multi‐stimuli‐responsive (enzyme/ROS/pH) release at infection sites. Exhibiting targeted antifungal activity against Sclerotium rolfsii, modulating plant antioxidant defense, and demonstrating favorable biosafety across plant, soil, and ...
Guangming Ma, Ying Zou, Yao Wang, Huiyan Li, Jinlin Li, Tianfu Liu, Xiaohong Pan   +6 more
wiley   +1 more source

The Role of Neurokinin B in the Regulation of the Preovulatory LH Surge in Ewes [PDF]

, 2013
Hypothalamic input is vital to the regulation of reproductive function. Gonadotropin-releasing hormone (GnRH) is secreted by hypothalamic GnRH neurons into the hypophysial portal circulation.
Porter, Katrina L.
core   +1 more source

Reanalysis of the rat proestrous LH surge by deconvolution analysis

, 1993
Pages R240–R245: J. D. Veldhuis, M. L. Johnson, and R. V. Gallo. “Reanalysis of the rat proestrous LH surge by deconvolution analysis.” Page R244: Reference 7 was inadvertently dropped from the reference list by the printer. It should read: 7. Gallo, R.
M. L. Johnson, R. V. Gallo, J. D. Veldhuis   +2 more
core   +2 more sources