Targeting Mitochondria in Aging‐Related Diseases: Therapeutic Potential and Obstacles
MedComm, Volume 7, Issue 6, June 2026.This article systematically summarized the specific mechanism of aging‐related diseases caused by mitochondrial dysfunction, and summarized the broad‐spectrum treatment methods and disease targeted treatment strategies for mitochondria. At the same time, it also pointed out the dilemma faced by mitochondrial targeted treatment.
Zijie Xiang +12 more
wiley +1 more source
High-Fat and High-Sugar Diet Induces Murine Premature Ovarian Failure by Promoting Mitochondrial Oxidative Phosphorylation Response. [PDF]
Food Sci NutrLi K +6 more
europepmc +1 more source
MedComm, Volume 7, Issue 6, June 2026.To define the mechanisms of sensitivity to PP2A inhibitors (PP2Ai), we combined molecular profiling of PP2Ai responses with genome‐wide genetic screens. PP2Ai preferentially target mesenchymal pancreatic ductal adenocarcinoma (PDAC) cells and engage pathways linked to transcriptional elongation, splicing, metabolism, and ER stress response factors ...
Janine Murr +37 more
wiley +1 more source
hnRNPA2B1 restrains granulosa cell ferroptosis by m<sup>6</sup>A/SLC7A11 in premature ovarian failure. [PDF]
J Ovarian ResXiong J, He L, Zhang Y, Zhao X.
europepmc +1 more source
Metabolic Regulation of Immune Responses: Molecular Mechanisms, Diseases, and Therapeutic Targets
MedComm, Volume 7, Issue 6, June 2026.FBP1 loss drives immune evasion and therapy resistance by enhancing glycolysis, STAT3 activation, and PD‐L1 expression, leading to T cell exhaustion and NK cell inhibition. FBP1 restoration, via LNP‐mRNA or epigenetic modulation, reverses these immunosuppressive effects, reactivates cytotoxic T cells, promotes M1 macrophage polarization, and enhances ...
Chunwei Li +10 more
wiley +1 more source
Correlation between intestinal flora and glucuronidase indexes and sex hormone levels and their diagnostic efficacy evaluation for premature ovarian failure. [PDF]
BMC Womens HealthZhang Y +6 more
europepmc +1 more source
Superstitions on Human Papillomavirus in Africa: A Scoping Review
Public Health Challenges, Volume 5, Issue 2, June 2026.Africa bears a high burden of HPV‐induced diseases; this scoping review explored how superstitions and cultural beliefs fuel vaccine hesitancy. There are widespread myths and opposition from cultural/religious leaders that drive HPV vaccine hesitancy; targeted and culturally sensitive campaigns/educations are essential to improve vaccine uptake and ...
Jimoh Amzat +6 more
wiley +1 more source
The effects of probiotics, prebiotics, and synbiotics on aversive memory in a premature ovarian failure model in rat. [PDF]
Physiol RepMadahali MH +4 more
europepmc +1 more source
Public Health Challenges, Volume 5, Issue 2, June 2026.University students show limited fertility awareness and less favorable attitudes toward parenthood. Misconceptions about age‐related fertility decline and infertility risks may delay informed decisions. Attitudes vary by age, ethnicity, and religion, highlighting the need for structured, age‐appropriate fertility education and counseling to support ...
Osin Gurung +3 more
wiley +1 more source
Optimal transplantation strategies for stem cell treatment in premature ovarian failure: a network meta-analysis. [PDF]
Stem Cell Res TherZiwei G, Shuang N, Di W, Li J.
europepmc +1 more source