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Maturitas, 1996
Premature ovarian failure (POF) is common, affecting approximately 1% of women. It is defined as gonadal failure before the age of 40 and patients may clinically present with either primary or secondary amenorrhoea. This review concentrates on the clinical aspects of POF, with sequential discussion on the aetiology and epidemiology, clinical ...
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Premature ovarian failure (POF) is common, affecting approximately 1% of women. It is defined as gonadal failure before the age of 40 and patients may clinically present with either primary or secondary amenorrhoea. This review concentrates on the clinical aspects of POF, with sequential discussion on the aetiology and epidemiology, clinical ...
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Familial Premature Ovarian Failure
Obstetrical & Gynecological Survey, 1985Premature menopause, ovarian failure younger than 40 years of age, is relatively rare but may preclude childbearing for some women who delay attempts at fertility. We present five kindreds in which a genetic association for premature ovarian failure is strongly suggested.
D R, Mattison +5 more
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Genes and premature ovarian failure
Molecular and Cellular Endocrinology, 1998Premature ovarian failure (POF) is an heterogeneous syndrome. Among genetic causes, X monosomy as in Turner syndrome or X deletions and translocations are known to be responsible for POF. The genes involved in ovarian function, located on the X chromosome are still unknown. On the other hand, autosomal abnormalities have been identified in POF patients
S, Christin-Maitre +3 more
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Incidence of Premature Ovarian Failure
Obstetrical & Gynecological Survey, 1987To assess the occurrence of premature ovarian failure, the age-specific incidence rates of natural menopause were determined for a cohort of 1858 women born between 1928 and 1932. These women were identified as Rochester, Minnesota residents in 1950 and were followed for date and type of menopause.
C B, Coulam, S C, Adamson, J F, Annegers
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Genetics of premature ovarian failure
Current Opinion in Obstetrics & Gynecology, 2015To provide an overview on the genetic basis of premature ovarian failure (POF) with specific attention to recently published molecular genetic studies.POF is an insidious cause of female infertility. Despite enormous efforts to understand the genetic pathogenesis, we know almost nothing but Turner syndrome and Fragile X syndrome. The era of genome-wide
Ekrem M, Bilgin, Ertug, Kovanci
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Management of premature ovarian failure
Best Practice & Research Clinical Obstetrics & Gynaecology, 2009Premature ovarian failure (POF), a major life-changing condition that affects a significant proportion of young women, remains an enigma and the researcher's minefield. As women increasingly survive childhood cancers due to improved iatrogenic interventions, the number of POF sufferers will inevitably increase.
Nick, Panay, Emmanuel, Kalu
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Premature ovarian failure and pregnancy
Archives of Gynecology and Obstetrics, 2005A case study of a woman with presumed premature menopause is presented.After more than 4 years of premature menopause judged by subjective symptoms, bleeding history, and postmenopausal levels of gonadotropins, a woman conceived spontaneously 2 months after the start of hormone replacement treatment (HRT).
Vandborg, M, Lauszus, F F
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Premature ovarian failure and dehydroepiandrosterone
Fertility and Sterility, 2009Since the first successful birth at our center following treatment with DHEA in a patient with premature ovarian failure (POF), all subsequent patients with POF underwent the same treatment protocol. Receiving very encouraging results (FSH level was decreased in the first five patients and all achieved pregnancy), it was decided to study the action of ...
Leonidas, Mamas, Eudoxia, Mamas
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Autoimmunity and premature ovarian failure
Current Opinion in Obstetrics & Gynecology, 2007The different patterns of autoreactivity that may account for the premature infertility observed in patients with premature ovarian failure are described.Animal model studies have detailed fundamental immune dysregulatory patterns that induce ovarian failure in the context of global polyglandular involvement, as well as autoimmune mechanisms that ...
Vincent K, Tuohy, Cengiz Z, Altuntas
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Pregnancies After Premature Ovarian Failure
Obstetrics & Gynecology, 1986Six women who conceived after a diagnosis of premature ovarian failure are discussed. Two pregnancies occurred while the women were receiving conjugated estrogen therapy, two while taking oral contraceptives, and two women conceived spontaneously. The possible role of exogenous estrogens in sensitizing the granulosa cells to the effect of follicle ...
M M, Alper, E E, Jolly, P R, Garner
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