BMC Women's Health, 2023 Background In premature ovarian insufficiency, the cessation of menstruation, and cessation of ovarian function occurs before the age of 40, and this phenomenon is associated with many complications and problems for women.
Sara Jambarsang +3 more
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Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise [PDF]
, 2011 The mechanism of chemotherapy-induced acceleration of ovarian aging is not fully understood. We used doxorubicin, a widely used cancer chemotherapeutic, in a variety of in vivo xenograft, and in vitro models to investigate the impact of chemotherapy ...
Darzynkiewicz, Zbigniew +3 more
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Optimizing Female Infertility in Premature Ovarian Insufficiency
Düzce Tıp Fakültesi Dergisi, 2022 Premature ovarian failure is a complex pathology with numerous etiologies and multiple system sequelae resulting for early deprivation of ovarian sex hormones. In the studies to determine the etiology, it is seen that many patients are in the unexplained
Pınar Çağlar Aytaç
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Effect of hyperthyroidism on circulating prolactin and hypothalamic expression of tyrosine hydroxylase, prolactin signaling cascade members and estrogen and progesterone receptors during late pregnancy and lactation in the rat [PDF]
, 2017 Hyperthyroidism (HyperT) compromises pregnancy and lactation, hindering suckling-induced PRL release. We studied the effect of HyperT on hypothalamic mRNA (RT-qPCR) and protein (Western blot) expression of tyrosine hydroxylase (TH), PRL receptor (PRLR ...
Jahn, Graciela Alma +4 more
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Premature Ovarian Failure [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2008 Over the last 40 years or so, there has been a significant rise in the number of women in the western world who have had their ovaries surgically removed prior to the age of natural menopause. The vast majority of these women were undergoing hysterectomy at the time, usually for a benign gynaecological condition such as menstrual dysfunction ...
Marcel Cedars +2 more
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Thyroxine-binding globulin: investigation of microheterogeneity [PDF]
, 1981 Preparations of T4-binding globulin (TBG) from human serum was performed using only two affinity chromatography steps. Purity of the protein was demonstrated by a single band in overloaded disc and sodium dodecyl sulfate electrophoresis, equimolar ...
Gärtner, Roland +4 more
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The need to identify novel biomarkers for prediction of premature ovarian insufficiency (POI)
Middle East Fertility Society Journal, 2022 Background Premature ovarian failure (POF)/premature ovarian insufficiency (POI) is characterized by disrupting ovarian function under 40 years old. A major health problem of this disorder is female infertility. There are no proven treatments to increase
Roya Kabodmehri +3 more
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Reproductive and developmental effects of phthalate diesters in females. [PDF]
, 2013 Phthalate diesters, widely used in flexible plastics and consumer products, have become prevalent contaminants in the environment. Human exposure is ubiquitous and higher phthalate metabolite concentrations documented in patients using medications with ...
Chambers, Christina +2 more
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Investigation of
BMC Women's Health, 2002 Background Spontaneous premature ovarian failure presents most commonly with secondary amenorrhea. Young women with the disorder are infertile and experience the symptoms and sequelae of estrogen deficiency.
Nelson Lawrence M +4 more
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Karyotype Evaluation in Patients with Premature Ovarian Failure
Forbes Tıp Dergisi, 2020 INTRODUCTION: Chromosome anomalies are one of the major causes of premature ovarian failure and the importance of chromosome analysis in reproductive management has been confirmed.
Aslı Akdöner +2 more
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