Results 261 to 270 of about 516,689 (292)

Premature ovarian insufficiency and infertility

Australian Journal of General Practice, 2023
Premature ovarian insufficiency (POI) is the loss of ovarian function before the age of 40 years and can be spontaneous or iatrogenic. It is an important cause of infertility, and the diagnosis should be considered in any woman presenting with oligo/amenorrhoea, even in the absence of menopausal symptoms suchas hot flushes.The aim of this article is to
Waduge, Dhanushi Fernando, Amanda, Vincent, Karen, Magraith   +2 more
openaire   +2 more sources

The global prevalence of premature ovarian insufficiency: a systematic review and meta-analysis

Climacteric, 2022
Objective The objective of this review was to answer the global prevalence of premature ovarian insufficiency (POI), and explore the associated factors including etiopathology and regions with POI. Methods The search was conducted on reports from a total
M. Li, Y. Zhu, J. Wei, L. Chen, S. Chen, D. Lai   +5 more
semanticscholar   +1 more source

Sexuality in premature ovarian insufficiency

Climacteric, 2019
Sexuality in women with spontaneous premature ovarian insufficiency (POI) deserves attention because of the young age and the distressing impact of such a life-changing diagnosis. Biomedical and psychosocial factors work in concert to determine significant changes of sexual function.
R. E. Nappi, L. Cucinella, E. Martini, M. Rossi, L. Tiranini, S. Martella, D. Bosoni, C. Cassani   +7 more
openaire   +3 more sources

Epidemiology, genetic etiology and intervention of premature ovarian insufficiency.

Endocrine reviews
Premature ovarian insufficiency (POI) is a highly heterogeneous reproductive disorder in both its etiology and clinical presentation. The epidemiological characteristics of POI suggest that its occurrence likely involves a combination of genetic and ...
Ting Guo, Hongyuan Liu, Bing-Ying Xu, Yu Qi, Ke-Yan Xu, Xin-Yi Wu, Xinmiao He, Ying-Ying Qin, Zi-Jiang Chen   +8 more
semanticscholar   +1 more source

Premature ovarian insufficiency

Endocrine Abstracts, 2014
Premature ovarian failure is defined as amenorrhea with hypo-oestrogenism and elevated gonadotrophins occurring before the age of 40 years. In theory, ovarian failure may occur because of a decreased pool of primordial follicles, because ovarian apoptosis is increased or accelerated or because the follicle maturation is interrupted before the ...
openaire   +2 more sources

Buspirone ameliorates premature ovarian insufficiency evoked by cyclophosphamide in female rats; attention to AMPK/Nrf2/HO-1, α-Klotho/NLRP3/Caspase-1, and Caspase-3-mediated apoptosis interplay.

Toxicology and Applied Pharmacology
This study aims to investigate the protective impact of buspirone (BUS) against cyclophosphamide (CPA)-induced premature ovarian insufficiency (POI) by focusing on pyroptosis, apoptosis, and the AMPK/Nrf2/HO-1 signaling pathway.
Waleed A I Khallaf, Ehab E. Sharata, M. Attya, R. Rofaeil, M. Khalaf, Ramadan A. M. Hemeida, A. M. Abo-youssef   +6 more
semanticscholar   +1 more source

Repurposing levomilnacipran to attenuate premature ovarian insufficiency induced by cyclophosphamide in female Wistar albino rats through modulation of TLR4/p38-MAPK/NF-κB p65, caspase-3-driven apoptosis, and Klotho protein expression.

Food and Chemical Toxicology
AIM This study aims to explore the mitigative impact of levomilnacipran (LVM) against cyclophosphamide (CPA)-induced premature ovarian insufficiency by targeting TLR4/p38 MAPK/NF-κB p65, and klotho expression.
R. Rofaeil, Ehab E. Sharata, M. Attya, A. M. Abo-youssef, Ramadan A. M. Hemeida, M. Khalaf   +5 more
semanticscholar   +1 more source

Decoding premature ovarian insufficiency: A full spectrum review from epidemiology to management with emphasis on cyclophosphamide-evoked ovarian injury.

Food and Chemical Toxicology
Premature ovarian insufficiency (POI) is a complex condition characterized by the termination of ovarian function before the age of 40, affecting approximately 1% of women within this age group. This review offers a comprehensive overview of POI aspects,
Ehab E. Sharata, M. Attya, M. Khalaf, R. Rofaeil, A. M. Abo-youssef, Ramadan A. M. Hemeida   +5 more
semanticscholar   +1 more source

Premature Ovarian Insufficiency

2017
Premature ovarian insufficiency is a multicausal non-frequent disease (1%) that has a high impact on women health; not only because it impairs fertility but it also has huge effects on global health due to hypoestrogenism, osteoporosis, and cardiovascular risks.
Allison L. Goetsch, Dana Kimelman, Teresa K. Woodruff   +2 more
openaire   +1 more source

Diagnosis and management of premature ovarian insufficiency

Best Practice & Research Clinical Endocrinology & Metabolism, 2021
Premature ovarian insufficiency (POI) is a complex clinical syndrome with life-changing physiological and psychological consequence in young women of reproductive age. However, the understanding of the etiology, diagnosis and optimal intervention strategies for this condition remains poorly understood.
Rumana, Rahman, Nick, Panay
openaire   +2 more sources