Mesenchymal stem cell therapy for premature ovarian insufficiency: progress and challenges. [PDF]
Shao Z, Liang L, Xue Y, Zhu T, Wen Q.
europepmc +1 more source
A bidirectional 2-sample Mendelian randomization study of depressed mood and premature ovarian insufficiency. [PDF]
Chen K +5 more
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hAECs restore follicular development in premature ovarian insufficiency via IGFBP2/IGF1R-mediated intercellular communication. [PDF]
Cao W +8 more
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Unveiling mitochondrial and PANoptosis-related biomarkers for premature ovarian insufficiency. [PDF]
Ma Z, Sun H.
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Pathogenic mechanisms and therapeutic potential of the microbiome in premature ovarian insufficiency. [PDF]
Ma S, Zheng L, Zhuang X, Wang M, Zou Y.
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Novel variants associated with premature ovarian insufficiency in Russian adolescents. [PDF]
Tsabai P +21 more
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MCM8-9 helicase activity protects primordial germ cell development to prevent premature ovarian insufficiency. [PDF]
Jiao X +5 more
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Premature ovarian insufficiency
Premature ovarian insufficiency (POI) is a cause of infertility and endocrine dysfunction in women, defined by loss of normal, predictable ovarian activity before the age of 40 years. POI is clinically characterized by amenorrhoea (primary or secondary) with raised circulating levels of follicle-stimulating hormone.
Philippe Touraine +5 more
semanticscholar +18 more sources
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Premature ovarian insufficiency
Current Opinion in Endocrine and Metabolic Research, 2023Natural menopause typically occurs between the ages of 46 to 55 years. Premature ovarian insufficiency or premature menopause refers to compromised ovarian follicular activity, occurring spontaneously or because of medical interventions, prior to the age of 40 years.
Svetlana Vujovic +4 more
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International audienceOvarian deficiency, including diminished ovarian reserve and premature ovarian insufficiency, represents one of the main causes of female infertility.
Celia Ravel +2 more
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