Results 11 to 20 of about 44,110 (224)

The antimalarial drug mefloquine enhances TP53 premature termination codon readthrough by aminoglycoside G418. [PDF]

PLoS ONE, 2019
Nonsense mutations constitute ~10% of TP53 mutations in cancer. They introduce a premature termination codon that gives rise to truncated p53 protein with impaired function.
Michael W Ferguson, Chloe A N Gerak, Christalle C T Chow, Ettore J Rastelli, Kyle E Elmore, Florian Stahl, Sara Hosseini-Farahabadi, Alireza Baradaran-Heravi, Don M Coltart, Michel Roberge   +9 more
doaj   +2 more sources

Ribosomes slide on lysine-encoding homopolymeric A stretches [PDF]

eLife, 2015
Protein output from synonymous codons is thought to be equivalent if appropriate tRNAs are sufficiently abundant. Here we show that mRNAs encoding iterated lysine codons, AAA or AAG, differentially impact protein synthesis: insertion of iterated AAA ...
Kristin S Koutmou, Anthony P Schuller, Julie L Brunelle, Aditya Radhakrishnan, Sergej Djuranovic, Rachel Green   +5 more
doaj   +5 more sources

Effect of small molecule eRF3 degraders on premature termination codon readthrough. [PDF]

Nucleic Acids Res, 2021
Baradaran-Heravi A, Balgi AD, Hosseini-Farahabadi S, Choi K, Has C, Roberge M.   +5 more
europepmc   +2 more sources

Amber codon is genetically unstable in generation of premature termination codon (PTC)-harbouring Foot-and-mouth disease virus (FMDV) via genetic code expansion. [PDF]

RNA Biol, 2021
Hao R, Ma K, Ru Y, Li D, Song G, Lu B, Liu H, Li Y, Zhang J, Wu C, Zhang G, Hu H, Luo J, Zheng H.   +13 more
europepmc   +2 more sources

Premature termination codon: a tunable protein translation approach

BioTechniques, 2022
Cellular protein–protein interactions are largely dependent on the activities of signaling proteins. Here, we present a technique to tune gene expression at translation level based on G418-inducible readthrough premature termination codon (PTC-on).
Xiyao Cheng, Ting Zhou, Zixin Yang, Jingjing Zhou, Meng Gao, Yongqi Huang, Zhengding Su   +6 more
doaj   +1 more source

Stop Codon Context-Specific Induction of Translational Readthrough

Biomolecules, 2021
Premature termination codon (PTC) mutations account for approximately 10% of pathogenic variants in monogenic diseases. Stimulation of translational readthrough, also known as stop codon suppression, using translational readthrough-inducing drugs (TRIDs)
Mirco Schilff, Yelena Sargsyan, Julia Hofhuis, Sven Thoms   +3 more
doaj   +1 more source

Translational repression of NMD targets by GIGYF2 and EIF4E2.

PLoS Genetics, 2021
Translation of messenger RNAs (mRNAs) with premature termination codons produces truncated proteins with potentially deleterious effects. This is prevented by nonsense-mediated mRNA decay (NMD) of these mRNAs.
Boris Zinshteyn, Niladri K Sinha, Syed Usman Enam, Benjamin Koleske, Rachel Green   +4 more
doaj   +1 more source

A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay. [PDF]

Circulation, 2019
Seeger T, Shrestha R, Lam CK, Chen C, McKeithan WL, Lau E, Wnorowski A, McMullen G, Greenhaw M, Lee J, Oikonomopoulos A, Lee S, Yang H, Mercola M, Wheeler M, Ashley EA, Yang F, Karakikes I, Wu JC.   +18 more
europepmc   +2 more sources

Poly(A)-Binding Protein Regulates the Efficiency of Translation Termination

Cell Reports, 2020
Summary: Multiple factors influence translation termination efficiency, including nonsense codon identity and immediate context. To determine whether the relative position of a nonsense codon within an open reading frame (ORF) influences termination ...
Chan Wu, Bijoyita Roy, Feng He, Kevin Yan, Allan Jacobson   +4 more
doaj   +1 more source

The role of nucleotide composition in premature termination codon recognition. [PDF]

BMC Bioinformatics, 2016
Zahdeh F, Carmel L.
europepmc   +2 more sources