Premature termination codon: a tunable protein translation approach
BioTechniques, 2022 Cellular protein–protein interactions are largely dependent on the activities of signaling proteins. Here, we present a technique to tune gene expression at translation level based on G418-inducible readthrough premature termination codon (PTC-on).
Xiyao Cheng +6 more
doaj +2 more sources
Stops making sense: translational trade-offs and stop codon reassignment [PDF]
BMC Evolutionary Biology, 2011 Background Efficient gene expression involves a trade-off between (i) premature termination of protein synthesis; and (ii) readthrough, where the ribosome fails to dissociate at the terminal stop.
Elgar Greg S +6 more
doaj +3 more sources
397 Harnessing the potential of genetic compensation in amyotrophic lateral sclerosis [PDF]
Journal of Clinical and Translational ScienceObjectives/Goals: This study aims to explore transcriptional adaptation, where mutations in one gene trigger compensatory changes in related genes, and how this affects the variability in clinical manifestations of amyotrophic lateral sclerosis (ALS ...
Adriana Morales Gomez +2 more
doaj +2 more sources
Amber codon is genetically unstable in generation of premature termination codon (PTC)-harbouring Foot-and-mouth disease virus (FMDV) via genetic code expansion [PDF]
RNA Biology, 2021 Gaoyuan Song, Huanan Liu
exaly +2 more sources
Análisis genético y molecular del síndrome de Maroteaux-Lamy [PDF]
, 2008 [spa] Esta tesis es una contribución al conocimiento del síndrome de Maroteux-Lamy en el terreno de la genética molecular. El síndrome de Maroteaux-Lamy o mucopolisacaridosis de tipo VI (MPS VI) es una grave enfermedad hereditaria muy poco frecuente en ...
Garrido Fernández, Elena
core +6 more sources
Letter to the Editor: Liver Cell Models for Premature Termination Codon Readthrough Analyses. [PDF]
Hepatology, 2021 Amzal and colleagues (1) reported about the prospect of pharmacological premature termination codon (PMT) readthrough of ABCB11 mRNA in bile salt export pump deficiency, the latter causing progressive familial intrahepatic cholestasis (PFIC)-type 2.
Matakovic L, Li Q, van Ijzendoorn SCD.
europepmc +3 more sources
Characterization of new-generation aminoglycoside promoting premature termination codon readthrough in cancer cells [PDF]
RNA Biology, 2017 Olivier Namy, Timor Baasov, Laure Bidou
exaly +2 more sources
Novel small molecules potentiate premature termination codon readthrough by aminoglycosides. [PDF]
Nucleic Acids Res, 2016 International audienceNonsense mutations introduce premature termination codons and underlie 11% of genetic disease cases. High concentrations of aminoglycosides can restore gene function by eliciting premature termination codon readthrough but with low ...
Baradaran-Heravi A +15 more
europepmc +2 more sources
Stop Codon Context-Specific Induction of Translational Readthrough
Biomolecules, 2021 Premature termination codon (PTC) mutations account for approximately 10% of pathogenic variants in monogenic diseases. Stimulation of translational readthrough, also known as stop codon suppression, using translational readthrough-inducing drugs (TRIDs)
Mirco Schilff +3 more
doaj +1 more source
Translational repression of NMD targets by GIGYF2 and EIF4E2.
PLoS Genetics, 2021 Translation of messenger RNAs (mRNAs) with premature termination codons produces truncated proteins with potentially deleterious effects. This is prevented by nonsense-mediated mRNA decay (NMD) of these mRNAs.
Boris Zinshteyn +4 more
doaj +1 more source