Results 21 to 30 of about 44,110 (224)

Characterization of new-generation aminoglycoside promoting premature termination codon readthrough in cancer cells. [PDF]

RNA Biol, 2017
Bidou L, Bugaud O, Belakhov V, Baasov T, Namy O.   +4 more
europepmc   +2 more sources

Topical gentamicin 0.1% promotes collagen 7 expression in recessive dystrophic epidermolysis bullosa

Indian Dermatology Online Journal, 2022
Background: Currently, there is no cure for epidermolysis bullosa (EB) but few studies have explored the role of aminoglycosides in promoting collagen 7 expression in recessive dystrophic EB (RDEB).
Rahul Mahajan, Seema Manjunath, Manoj G Madakshira, Dipankar De, Sanjeev Handa, Debajyoti Chatterjee, Bishan D Radotra   +6 more
doaj   +1 more source

Novel small molecules potentiate premature termination codon readthrough by aminoglycosides. [PDF]

Nucleic Acids Res, 2016
Baradaran-Heravi A, Balgi AD, Zimmerman C, Choi K, Shidmoossavee FS, Tan JS, Bergeaud C, Krause A, Flibotte S, Shimizu Y, Anderson HJ, Mouly V, Jan E, Pfeifer T, Jaquith JB, Roberge M.   +15 more
europepmc   +2 more sources

Posttranscriptional gene regulation by spatial rearrangement of the 3' untranslated region. [PDF]

PLoS Biology, 2008
Translation termination at premature termination codons (PTCs) triggers degradation of the aberrant mRNA, but the mechanism by which a termination event is defined as premature is still unclear.
Andrea B Eberle, Lukas Stalder, Hansruedi Mathys, Rodolfo Zamudio Orozco, Oliver Mühlemann   +4 more
doaj   +1 more source

Codon usage biases co-evolve with transcription termination machinery to suppress premature cleavage and polyadenylation

eLife, 2018
Codon usage biases are found in all genomes and influence protein expression levels. The codon usage effect on protein expression was thought to be mainly due to its impact on translation.
Zhipeng Zhou, Yunkun Dang, Mian Zhou, Haiyan Yuan, Yi Liu   +4 more
doaj   +1 more source

Stop codon context influences genome-wide stimulation of termination codon readthrough by aminoglycosides

eLife, 2020
Stop codon readthrough (SCR) occurs when the ribosome miscodes at a stop codon. Such readthrough events can be therapeutically desirable when a premature termination codon (PTC) is found in a critical gene.
Jamie R Wangen, Rachel Green
doaj   +1 more source

Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs) [PDF]

, 2019
This review focuses on the use of oxadiazoles as translational readthrough-inducing drugs (TRIDs) to rescue the functional full-length protein expression in mendelian genetic diseases caused by nonsense mutations.
Campofelice A., Di Leonardo A., Lentini L., Melfi R., Pace A., Pibiri I., Tutone M.   +6 more
core   +1 more source

Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice [PDF]

, 2017
Megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS) is a congenital visceral myopathy characterized by severe dilation of the urinary bladder and defective intestinal motility. The genetic basis of MMIHS has been ascribed to spontaneous and
Alves, MM, Brooks, AS, Brosens, E, Brouwer, RWW, Burns, AJ, Christie, CK, de Mesy Bentley, KL, Djuwantono, T, Doukas, M, Halim, D, Han, Y, Hofstra, RMW, Jin, ZG, Lyu, Q, Miano, JM, Nanda, V, Oliver, D, Slivano, OJ, Stoop, H, Tibboel, D, van IJcken, WFJ, Verheij, JBGM, Wilson, MP, Xu, S, Yan, W   +24 more
core   +7 more sources

Rous Sarcoma Virus RNA Stability Element Inhibits Deadenylation of mRNAs with Long 3′UTRs

Viruses, 2017
All retroviruses use their full-length primary transcript as the major mRNA for Group-specific antigen (Gag) capsid proteins. This results in a long 3′ untranslated region (UTR) downstream of the termination codon. In the case of Rous sarcoma virus (RSV),
Vidya Balagopal, Karen L. Beemon
doaj   +1 more source

Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay

BMC Biology, 2009
Background Nonsense-mediated decay is a mechanism that degrades mRNAs with a premature termination codon. That some exons have premature termination codons at fixation is paradoxical: why make a transcript if it is only to be destroyed?
Hu Landian, Zhou Li, Wang Ping, Xin Dedong, Zhang Zhenguo, Kong Xiangyin, Hurst Laurence D   +6 more
doaj   +1 more source