Results 21 to 30 of about 418,363 (219)

Poly(A)-Binding Protein Regulates the Efficiency of Translation Termination

Cell Reports, 2020
Summary: Multiple factors influence translation termination efficiency, including nonsense codon identity and immediate context. To determine whether the relative position of a nonsense codon within an open reading frame (ORF) influences termination ...
Chan Wu, Bijoyita Roy, Feng He, Kevin Yan, Allan Jacobson   +4 more
doaj   +1 more source

Topical gentamicin 0.1% promotes collagen 7 expression in recessive dystrophic epidermolysis bullosa

Indian Dermatology Online Journal, 2022
Background: Currently, there is no cure for epidermolysis bullosa (EB) but few studies have explored the role of aminoglycosides in promoting collagen 7 expression in recessive dystrophic EB (RDEB).
Rahul Mahajan, Seema Manjunath, Manoj G Madakshira, Dipankar De, Sanjeev Handa, Debajyoti Chatterjee, Bishan D Radotra   +6 more
doaj   +1 more source

Translation initiation factor eIF3 promotes programmed stop codon readthrough. [PDF]

, 2015
Programmed stop codon readthrough is a post-transcription regulatory mechanism specifically increasing proteome diversity by creating a pool of C-terminally extended proteins.
von der Haar, Tobias, Beznoskova, Petra, Wagner, Susan, Valasek, Leos S, Jansen, Myrte E   +4 more
core   +1 more source

Codon usage biases co-evolve with transcription termination machinery to suppress premature cleavage and polyadenylation

eLife, 2018
Codon usage biases are found in all genomes and influence protein expression levels. The codon usage effect on protein expression was thought to be mainly due to its impact on translation.
Zhipeng Zhou, Yunkun Dang, Mian Zhou, Haiyan Yuan, Yi Liu   +4 more
doaj   +1 more source

Posttranscriptional gene regulation by spatial rearrangement of the 3' untranslated region. [PDF]

PLoS Biology, 2008
Translation termination at premature termination codons (PTCs) triggers degradation of the aberrant mRNA, but the mechanism by which a termination event is defined as premature is still unclear.
Andrea B Eberle, Lukas Stalder, Hansruedi Mathys, Rodolfo Zamudio Orozco, Oliver Mühlemann   +4 more
doaj   +1 more source

Stop codon context influences genome-wide stimulation of termination codon readthrough by aminoglycosides

eLife, 2020
Stop codon readthrough (SCR) occurs when the ribosome miscodes at a stop codon. Such readthrough events can be therapeutically desirable when a premature termination codon (PTC) is found in a critical gene.
Jamie R Wangen, Rachel Green
doaj   +1 more source

Translation Initiation Factors eIF3 and HCR1 Control Translation Termination and Stop Codon Read-Through in Yeast Cells [PDF]

, 2013
Translation is divided into initiation, elongation, termination and ribosome recycling. Earlier work implicated several eukaryotic initiation factors (eIFs) in ribosomal recycling in vitro.
Lucie Cuchalová, Lucie Cuchalová (153753), Wagner, Susan, Valasek, Leos S, Cuchalova, Lucie, Petra Beznosková (488568), Susan Wagner, Shoemaker, Christopher J, von der Haar, Tobias, Christopher J Shoemaker, Stanislava Gunišová (153731), Susan Wagner (488569), Beznoskova, Petra, Christopher J. Shoemaker (259606), Leoš Shivaya Valášek (153772), Gunisova, Stanislava, Stanislava Gunišová, Tobias von der Haar, Tobias von der Haar (80575), Petra Beznosková, Leoš Shivaya Valášek   +20 more
core   +2 more sources

Rous Sarcoma Virus RNA Stability Element Inhibits Deadenylation of mRNAs with Long 3′UTRs

Viruses, 2017
All retroviruses use their full-length primary transcript as the major mRNA for Group-specific antigen (Gag) capsid proteins. This results in a long 3′ untranslated region (UTR) downstream of the termination codon. In the case of Rous sarcoma virus (RSV),
Vidya Balagopal, Karen L. Beemon
doaj   +1 more source

Decoding accuracy in eRF1 mutants and its correlation with pleiotropic quantitative traits in yeast [PDF]

, 2010
Translation termination in eukaryotes typically requires the decoding of one of three stop codons UAA, UAG or UGA by the eukaryotic release factor eRF1.
Mugnier, Pierre M., von der Haar, Tobias, Gloria H Merritt (16282583), Mick F Tuite (16282592), Wesley R Naemi (16282586), Helen Webb (5178887), Pierre Mugnier (16282589), Webb, Helen M., Tobias von der Haar (80575), Merritt, Gloria H., Tuite, Mick F., Naemi, Wesley R.   +11 more
core   +1 more source

Amlexanox Enhances Premature Termination Codon Read-Through in COL7A1 and Expression of Full Length Type VII Collagen: Potential Therapy for Recessive Dystrophic Epidermolysis Bullosa. [PDF]

Journal of Investigative Dermatology, 2017
Cristina Has, Mei Chen, Andrew P South
exaly   +2 more sources