Results 41 to 50 of about 153,808 (291)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Identification and characterisation of vaginal bacteria-glycan interactions implicated in reproductive tract health and pregnancy outcomes

Nature Communications
Lactobacillus displacement from the vaginal microbiome associates with adverse health outcomes and is linked to increased risk of preterm birth. Glycans mediate bacterial adhesion events involved in colonisation and infection.
Virginia Tajadura-Ortega, Wengang Chai, Lauren A. Roberts, Yibing Zhang, Antonio Di Maio, Alexiane C. Decout, Benedita A. Pinheiro, Angelina S. Palma, Gian De Nicola, Lucia Riaposova, Belen Gimeno-Molina, Yun S. Lee, Hongzhi Cao, Vladimir Piskarev, Yukie Akune, Tiago R. D. Costa, Himani Amin, Lynne Sykes, Phillip R. Bennett, Julian R. Marchesi, Ten Feizi, Yan Liu, David A. MacIntyre   +22 more
doaj   +1 more source

Association among gestational diabetes mellitus, periodontitis and prematurity: a cross-sectional study

Archives of Endocrinology and Metabolism, 2022
Objective: Gestational diabetes mellitus (GDM) causes maternal and infant morbidity. Periodontitis is associated with adverse pregnancy outcomes. The aim of this study was to evaluate periodontal status, prematurity and associated factors in pregnant ...
Carla Andreotti Damante, Gerson Aparecido Foratori Junior, Paula de Oliveira Cunha, Carlos Antonio Negrato, Silvia Helena Carvalho Sales-Peres, Mariana Schutzer Ragghianti Zangrando, Adriana Campos Passanezi Sant’Ana   +6 more
doaj   +1 more source

From early stress to 12-month development in very preterm infants: Preliminary findings on epigenetic mechanisms and brain growth [PDF]

, 2018
Very preterm (VPT) infants admitted to Neonatal Intensive Care Unit (NICU) are at risk for altered brain growth and less-than-optimal socio-emotional development.
Borgatti, R., C., Squarcina, Carli, De, F., Brambilla, F., Sirgiovanni, Fumagalli, M., I., Giorda, L., Pozzoli, Montirosso, Rosario, Mosca, F., P., Dessimone, Provenzi, L., R., Cinnante, U., Triulzi   +13 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Glycomics of cervicovaginal fluid from women at risk of preterm birth reveals immuno-regulatory epitopes that are hallmarks of cancer and viral glycosylation

Scientific Reports
During pregnancy the immune system needs to maintain immune tolerance of the foetus while also responding to infection, which can cause premature activation of the inflammatory pathways leading to the onset of labour and preterm birth.
Gang Wu, Paola Grassi, Belen Gimeno Molina, David A. MacIntyre, Lynne Sykes, Phillip R. Bennett, Anne Dell, Stuart M. Haslam   +7 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Blindness incidence in Germany - A population-based study from Württemberg-Hohenzollern [PDF]

, 1999
Few data on the incidence of blindness in Germany are available. We analysed causes of legal blindness for the region Württemberg-Hohenzollern (population 5.5 million) in order to help fill in this gap.
Klauss, V., Krumpaszky, H. G., Lüdtke, R., Mickler, A., Selbmann, H. K.   +4 more
core   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Does field of view matter? Assessing its impact on Plus disease diagnosis in retinopathy of prematurity

International Journal of Retina and Vitreous
Purpose This study investigates the impact of field of view (FOV) on the diagnosis of Plus disease in retinopathy of prematurity (ROP), focusing on how different FOVs influence expert assessments.
Sayed Mehran Sharafi, Mobina Amanollahi, Nazanin Ebrahimiadib, Mohammad Hossein Nowroozzadeh, Marjan Imani Fooladi, Fatemeh Bazvand, Nader Mohammadi, Mohammad Bagher Rajabi, Hamid Riazi-Esfahani, Elias Khalili Pour   +9 more
doaj   +1 more source