Results 51 to 60 of about 614,591 (385)

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Glycomics of cervicovaginal fluid from women at risk of preterm birth reveals immuno-regulatory epitopes that are hallmarks of cancer and viral glycosylation

Scientific Reports
During pregnancy the immune system needs to maintain immune tolerance of the foetus while also responding to infection, which can cause premature activation of the inflammatory pathways leading to the onset of labour and preterm birth.
Gang Wu, Paola Grassi, Belen Gimeno Molina, David A. MacIntyre, Lynne Sykes, Phillip R. Bennett, Anne Dell, Stuart M. Haslam   +7 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Retinopathy of prematurity: Addressing the emerging burden in developing countries

Journal of Family Medicine and Primary Care, 2020
Retinopathy of prematurity has emerged and continues to be one of the leading causes of avoidable childhood blindness in low- and middle-income countries over the past few years. A major reason is the lack of adoption of effective and efficient screening
Suraj Singh Senjam, Parijat Chandra
doaj   +1 more source

Attention and regional gray matter development in very preterm children at age 12 years [PDF]

, 2017
Objectives: This study examines the selective, sustained, and executive attention abilities of very preterm (VPT) born children in relation to concurrent structural magnetic resonance imaging (MRI) measures of regional gray matter development at age 12 ...
Bora, Samudragupta, Lean, Rachel E, Melzer, Tracy R, Watts, Richard, Woodward, Lianne J   +4 more
core   +2 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Does field of view matter? Assessing its impact on Plus disease diagnosis in retinopathy of prematurity

International Journal of Retina and Vitreous
Purpose This study investigates the impact of field of view (FOV) on the diagnosis of Plus disease in retinopathy of prematurity (ROP), focusing on how different FOVs influence expert assessments.
Sayed Mehran Sharafi, Mobina Amanollahi, Nazanin Ebrahimiadib, Mohammad Hossein Nowroozzadeh, Marjan Imani Fooladi, Fatemeh Bazvand, Nader Mohammadi, Mohammad Bagher Rajabi, Hamid Riazi-Esfahani, Elias Khalili Pour   +9 more
doaj   +1 more source

A data-driven health index for neonatal morbidities

iScience, 2022
Summary: Whereas prematurity is a major cause of neonatal mortality, morbidity, and lifelong impairment, the degree of prematurity is usually defined by the gestational age (GA) at delivery rather than by neonatal morbidity.
Davide De Francesco, Yair J. Blumenfeld, Ivana Marić, Jonathan A. Mayo, Alan L. Chang, Ramin Fallahzadeh, Thanaphong Phongpreecha, Alex J. Butwick, Maria Xenochristou, Ciaran S. Phibbs, Neda H. Bidoki, Martin Becker, Anthony Culos, Camilo Espinosa, Qun Liu, Karl G. Sylvester, Brice Gaudilliere, Martin S. Angst, David K. Stevenson, Gary M. Shaw, Nima Aghaeepour   +20 more
doaj   +1 more source

Brainstem auditory evoked responses in an equine patient population. Part II: foals. [PDF]

, 2014
BackgroundReports of the use of brainstem auditory evoked response (BAER) as a diagnostic modality in foals have been limited.Hypothesis/objectivesTo describe BAER findings and associated causes of hearing loss in foals.AnimalsStudy group 18 foals (15 ...
Aleman, M, Holliday, TA, Madigan, JE, Williams, DC   +3 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source