Results 121 to 130 of about 46,543 (259)

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

Advanced Materials, Volume 38, Issue 26, 8 May 2026.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade, Ashna A. Kumar, Samuel O. Nitschke, Paul Joyce, Elahe Minaei, Stephanie E. Reuter, Chelsea Penney, Holly Warren, Ruby Shepherd, Jeremy N. Dinoro, Gordon G. Wallace, Anthony Dosseto, Sameera Ansar, Naila Islam, Alistair Lochhead, George Sharbeen, Phoebe A. Phillips, Morteza Aghmesheh, Wayne J. Hawthorne, Kara L. Vine‐Perrow   +19 more
wiley   +1 more source

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP): A Comprehensive Review of Types, Pathophysiology, and Treatment Approaches

Brain and Behavior, Volume 16, Issue 5, May 2026.
Chronic inflammatory demyelinating polyneuropathy is an autoimmune disorder causing demyelination, leading to distal weakness, sensory loss, and autonomic dysfunction. Immune activation triggers macrophage‐mediated myelin damage and conduction failure.
Ayesha Khan, Arsal Khan, Kuldeep Dalpat Rai, Anzel Saeed, Harsh Kumar, Aneesh Kumar Sangtiani, Tehreem Fatima, Muhammad Tanveer Alam, Faiza Rajput, Sakshi Chawla, Hussain Haider Shah, Humaira Kalam   +11 more
wiley   +1 more source

Lessons From Two Cases of Life‐Threatening Hemorrhage Which Occurred Immediately Before Tooth Extraction in Elderly Cancer Patients With Diabetes

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Tooth extraction is often required before chemoradiotherapy in patients with cancer. We herein report two cases of elderly cancer patients who experienced life‐threatening hemorrhage immediately before scheduled extractions. Case 1 involved a 79‐year‐old man who underwent chemotherapy for malignant lymphoma.
Sumitaka Hagiwara, Reika Hasegawa, Shigeru Kusumoto, Shintaro Beppu, Nobuhiro Hanai   +4 more
wiley   +1 more source

A systematic review and meta-analysis on the safety and efficacy of premedication prior to elective intubation in neonates

Journal of Pediatric and Neonatal Individualized Medicine
Objective: Endotracheal intubation, as an emergent but also as an elective procedure, can be stressful and painful, causing hypoxemia, bradycardia, acidosis or increased intracranial pressure.
Ilias Chatziioannidis, Georgios N. Katsaras, Abraham Pouliakis, Zoi Arvanitaki, Dimitra Gialamprinou, Georgios Mitsiakos   +5 more
doaj   +1 more source

Through Two Ports: A Minimally Invasive Approach to Ovariectomy in the Raccoon (Procyon lotor (Linnaeus, 1758))

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT This report describes the first documented case of a two‐port laparoscopic ovariectomy (lapOVE) in a raccoon (Procyon lotor (Linnaeus, 1758)). A rescued, eight‐month‐old, 5.0 kg female raccoon, kept as a pet, was presented to the Veterinarium, clinic of Agricultural University of Georgia (Tbilisi, Georgia), for elective ovariectomy. Anesthesia
Lasha‐Giorgi Japaridze
wiley   +1 more source

Ultrasound-Guided Lateral Femoral Cutaneous Nerve Cryoneurolysis for Analgesia in Patients With Burns. [PDF]

, 2020
Autologous skin grafting from the thigh is frequently required for treatment of burns and is associated with intense pain at the donor site. Local anesthetic-based (LA) nerve blocks of the lateral femoral cutaneous nerve (LFCN) have been demonstrated to ...
Fiallo, Alfredo, Finneran, John J, Gabriel, Rodney A, Hamilton, Jeffrey R, Ilfeld, Brian M, Lee, Jeanne G, Swisher, Matthew W   +6 more
core  

Efficacy and safety of fruquintinib combined with albumin‐bound paclitaxel as second‐line therapy for advanced gastric cancer following failure of PD‐1 inhibitor‐containing treatment (TACTIC GC‐01): A phase II single‐arm study

International Journal of Cancer, Volume 158, Issue 9, Page 2219-2228, 1 May 2026.
What's new? Anti‐angiogenic drugs have shown promising efficacy as a second‐line treatment for advanced gastric cancer. However, it remains unclear how alterations in the tumor microenvironment following first‐line immunotherapy may impact tumor angiogenesis and influence subsequent therapeutic outcomes. This single‐arm study prospectively explored the
Xiaoting Ma, Kai Ou, Xiu Liu, Biyang Cao, Wenwei Yang, Jingyu Lu, Letian Zhang, Qi Wang, Lizhen Gao, Zhichao Jiang, Yongkun Sun, Lin Yang   +11 more
wiley   +1 more source

Child's Temperament as Risk Factor for Preoperative Anxiety—A Secondary Analysis of the ALPAKA Trial

Pediatric Anesthesia, Volume 36, Issue 5, Page 540-548, May 2026.
ABSTRACT Background Preoperative anxiety is common in young children and may impair cooperation during anesthesia induction. Some temperament traits have been associated with higher anxiety levels in the preoperative phase. While midazolam is widely used for anxiolysis, individual responses vary and may be influenced by underlying psychological ...
Thorben Jacobi, Sebastian Walter, Andrea Pickartz, Georg Baller, Tobias Becher, Ingmar Lautenschläger, Armin Sablewski   +6 more
wiley   +1 more source

Beneficial Effects of Low-Dose Intravenous Dexmedetomidine Premedication in Patient Undergoing Laparoscopic Cholecystectomy Under General Anesthesia: A Prospective, Double-Blind, Randomized Controlled Trial

Drug Design, Development and Therapy
Longbin Zheng,1,* Tao Fang,2,* Wei Zhang,1 Xiaojing Zhang,1 Zhiqiang Ren,1 Weimin Qin,1 Wenbo Liang,1 Qing Ma,1 Ning Yin1 1Department of Anesthesiology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, People’s ...
Zheng L, Fang T, Zhang W, Zhang X, Ren Z, Qin W, Liang W, Ma Q, Yin N   +8 more
doaj  

PREMEDICATION [PDF]

BMJ, 1935
openaire   +2 more sources