Results 141 to 150 of about 46,543 (259)
Elranatamab: Mechanism of Action, Clinical, and Translational Science
ABSTRACT Elranatamab (ELREXFIO) is a humanized bispecific antibody approved for patients with relapsed/refractory multiple myeloma (RRMM). Elranatamab engages CD3 on T cells and B‐cell maturation antigen (BCMA) on myeloma cells to induce T cell–mediated myeloma cell cytolysis.
Mohamed Elmeliegy +10 more
wiley +1 more source
Effect of obesity and thoracic epidural analgesia on perioperative spirometry [PDF]
Background. Lung volumes in obese patients are reduced significantly in the postoperative period. As the effect of different analgesic regimes on perioperative spirometric tests in obese patients has not yet been studied, we investigated the effect of ...
Reber, A. +3 more
core
Abstract Background Pregabalin reduces excitatory neurotransmitter release and is used for anxiolysis in humans, cats, and horses. The effects of pregabalin on equine recovery following isoflurane anaesthesia are unknown. Objectives To determine if pre‐anaesthetic oral pregabalin influences recovery time and/or quality from isoflurane anaesthesia in ...
Abigail Blanton +8 more
wiley +1 more source
Delayed urticaria during treatment with anti‐CGRP monoclonal antibodies in migraine
Abstract Objective To characterize clinical presentation and management of urticaria associated with calcitonin gene‐related peptide (CGRP) ‐targeting monoclonal antibodies (mAbs) for migraine prophylaxis. Background CGRP‐targeting mAbs are effective in migraine prophylaxis, but have been associated with hypersensitivity reactions, including urticaria.
Christoph T. Berger +5 more
wiley +1 more source
ABSTRACT The objectives of this study were to evaluate ATIP pharmacokinetics (PK) in healthy Beagle dogs after IM and IN dosing (Phase I), and to compare the rate of reversal of IM versus IN routes for xylazine (XYL) sedation (Phase II). This study was comprised of two sequential, randomized, crossover experiments. The initial PK study dosed ATIP by IN
Vanessa E. Cowan +7 more
wiley +1 more source
Optimizing CT‐Based Models for Predicting Whole‐Body Fat in Rabbits
ABSTRACT This study evaluated three computed tomography (CT)‐based automatic fat segmentation methods and identified the optimal regression model for predicting whole‐body fat in rabbits. CT scans were performed on 21 postmortem companion rabbits to estimate fat percentage (Fat%‐CT) and fat volume (FV‐CT, mm3).
Panida Pongvittayanon +6 more
wiley +1 more source
Norepinephrine Involvment in Penile Detumescence [PDF]
Diederichs, W. +3 more
core +1 more source
Abstract Objective To determine optimal portal position for thoracolumbar unilateral biportal endoscopy (UBE) spine surgery in dogs. Study design Experimental ex vivo cadaveric and in vivo preclinical study. Animals Seven cadavers and three healthy purpose‐bred Beagles.
Sanghyun Nam +6 more
wiley +1 more source

