Results 81 to 90 of about 51,943 (303)

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

PATIENTS WITH ALLERGIES – PREOPERATIVE PREPARATION AND PREMEDICATION

Journal of IMAB
Purpose: The study investigates the need and effectiveness of preoperative prick test corticosteroids as antiallergic premedication for patients with a history of allergic reactions undergoing surgery under general anesthesia, focusing on ...
Gergana Ivanova, Margarita Atanasova
doaj   +1 more source

The importance of preoperative preparation of pediatric patients

Trends in Pediatrics
Preoperative preparation is a complex series of steps aimed at establishing the conditions for selecting an individualized perioperative plan, bringing the child to the best possible state of health state, stabilizing higher-risk patients and reducing ...
Dušica Simić, Duygu Kara, Katarina Stančev, Ivana Budić, Ivana Petrov   +4 more
doaj   +1 more source

Comparison of nebulized dexmedetomidine and ketamine for premedication in pediatric patients undergoing hernia repair surgery: a randomized comparative trial [PDF]

, 2022
Geeta Singariya, Namita Malhotra, Manoj Kamal, Rishabh Jaju, Shruti Aggarwal, Pooja Bihani   +5 more
openalex   +1 more source

Pharmacological inhibition of hydroxysteroid 11‐beta dehydrogenase type 1 (11‐βHSD1) after myocardial infarction preserves cardiac function in a translational mini‐pig model

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Plasma glucocorticoids increase acutely after MI, thereafter tissue levels are amplified selectively within cells expressing 11‐ßhydroxysteroid dehydrogenase type 1 (11‐ßHSD1) that regenerates active glucocorticoids from circulating metabolites.
Sara Al Disi, Raimondo Ascione, Shazia Khan, Thomas Johnson, Eva Sammut, Vito Domenico Bruno, Daniel Baz Lopez, Carol‐Anne James, Joanna Simpson, Natalie Z. Homer, Michael Millar, Trisha Singh, Alex von Kreigsheim, Nick L. Mills, Brian R. Walker, Ruth Andrew, Scott P. Webster, Andrew Whittaker, Adrian Freeman, Gillian A. Gray   +19 more
wiley   +1 more source

Hemodynamic stability and analgesic effects of intravenous dexmedetomidine premedication in adult patients undergoing coronary artery bypass graft surgery

Research in Cardiovascular Medicine, 2018
Background: Sternotomy for coronary artery bypass surgery operation is associated with neuropathic pain, hypertension, tachycardia, agitation, and several other complications.
Zahra Faritus, Ali Sadeghi, Mohsen Ziaiifard, Manijeh Yousefi Moghaddam, Ali Sadeghpour Tabaei, Farhad Gorjipour   +5 more
doaj   +1 more source

T‐Cell–Redirecting Immunotherapies in Relapsed/Refractory Mantle Cell Lymphoma: Current Evidence, Sequencing, and Future Directions

European Journal of Haematology, EarlyView.
ABSTRACT Relapsed/refractory (R/R) mantle cell lymphoma (MCL) remains a therapeutic challenge, particularly in patients with high‐risk features or prior exposure to Bruton's tyrosine kinase inhibitors (BTKis). The advent of T‐cell–redirecting immunotherapies, including chimeric antigen receptor T‐cell (CAR‐T) therapy and bispecific antibodies (BsAbs ...
Santino Caserta, Enrica Antonia Martino, Ernesto Vigna, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Fortunato Morabito, Massimo Gentile   +10 more
wiley   +1 more source

Safety and Tolerability of COVID-19 Vaccine in Mast Cell Disorders Real-Life Data from a Single Centre in Italy

Vaccines
Background In the past three years, COVID-19 has had a significant impact on the healthcare systems and people’s safety worldwide. Mass vaccinations dramatically improved the health and economic damage caused by SARS-CoV-2.
Stefania Nicola, Marina Mazzola, Luca Lo Sardo, Erika Montabone, Iuliana Badiu, Federica Corradi, Maria Carmen Rita Azzolina, Maurizio Gaspare Dall’Acqua, Giovanni Rolla, Irene Ridolfi, Anna Quinternetto, Luisa Brussino   +11 more
doaj   +1 more source

Bilateral laryngeal paralysis (aplegia) occurring late during the recovery of a horse after orthopaedic surgery

Equine Veterinary Education, EarlyView.
Summary A 9‐year‐old male castrated Standardbred was presented for evaluation of a comminuted right front first phalanx fracture. On initial clinical examination, mild haemoconcentration and increased vital parameters were noted. After overnight hospitalisation, the horse underwent general anaesthesia for surgical fracture repair.
I. Lutvikadic, K. Hopster, B. Driessen
wiley   +1 more source

The effect of premedication with butorphanol or methadone on the ease of duodenal intubation

Veterinary Evidence
PICO Question In adult dogs undergoing upper gastrointestinal (GI) endoscopy, does premedication with butorphanol compared to premedication with methadone make duodenal intubation easier?   Clinical bottom line Category of research Treatment.
Charlotte Swanson
doaj   +1 more source