Results 101 to 110 of about 2,600,864 (356)

Identification of Compound Heterozygous CYP11A1 Variants via Reanalysis of Clinical Sequencing Data

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT A molecular diagnosis is currently achievable in approximately 50% of patients assessed by clinical geneticists at tertiary care centres. Next‐Generation Sequencing Panels contain a defined group of genes associated with a clinically defined set of phenotypes.
Ana Acosta Bedón, Vahid Akbari, Ralph Rothstein, Alexandra Inman, Sanjiv Bhalla, Jianghong An, Jan M. Friedman, Rosanna Weksberg, Cornelius Boerkoel, Steven J. M. Jones, William T. Gibson   +10 more
wiley   +1 more source

Prenatal Exposure to Perfluoroalkyl Substances and Adiposity in Early and Mid-Childhood

Environmental Health Perspectives, 2016
Background: Few studies have examined whether prenatal exposure to perfluoroalkyl substances (PFASs) is associated with childhood adiposity. Objective: We examined associations of prenatal exposure to PFASs with adiposity in early and mid-childhood ...
Ana María Mora, Emily Oken, S. Rifas-Shiman, Thomas F Webster, M. Gillman, A.M. Calafat, X. Ye, S. Sagiv   +7 more
semanticscholar   +1 more source

A Population‐Based Assessment of Cancer Risk in Children With VACTERL

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Cancer risk in children with VACTERL, a nonrandom co‐occurrence of ≥ 3 defects (vertebral, anal, cardiac, tracheoesophogeal fistula, renal, and limb), remains unclear. We evaluated this association in a population‐based study. We analyzed data from the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Study, a US registry linkage ...
Ji Yun Tark, Alexander Renwick, Giorgio Tettamanti, Rachel D. Harris, Tania A. Desrosiers, Andrew F. Olshan, Amanda E. Janitz, Michael E. Scheurer, Charles J. Shumate, Angela E. Scheuerle, Sharon E. Plon, Chad D. Huff, Ann Nordgren, Barbara Luke, Philip J. Lupo, Jeremy M. Schraw   +15 more
wiley   +1 more source

Famine mortality and contributions to later-life type 2 diabetes at the population level: a synthesis of findings from Ukrainian, Dutch and Chinese famines

BMJ Global Health
Since the 1970s, influential literature has been using famines as natural experiments to examine the long-term health impact of prenatal famine exposure at the individual level.
L H Lumey, Chihua Li, Cormac Ó Gráda
doaj   +1 more source

Methodological Issues in Assessing the Impact of Prenatal Drug Exposure

Substance Abuse: Research and Treatment, 2015
Prenatal drug exposure is a common public health concern that can result in perinatal complications, birth defects, and developmental disorders. The growing literature regarding the effects of prenatal exposure to specific drugs such as tobacco, alcohol,
Carolien Konijnenberg
doaj   +1 more source

The effects of socioeconomic status and indices of physical environment on reduced birth weight and preterm births in Eastern Massachusetts [PDF]

, 2008
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work
A Ellaway, Ariana Zeka, B Ritz, B Ritz, BA Coull, BG Link, BL Williams, CI Li, DJ Barker, EH Ha, GLIMMIX, GR Alexander, I Kawachi, J Dejmek, JJ Collins, Joel Schwartz, JS Lucas, K Mortimer, K Sexton, KM Godfrey, LC Messer, LW Pickle, M Bobak, M Bobak, M Jerrett, M Maisonet, M Roorda-Knape, M Wilhelm, M Wilhelm, MassGIS-EOEA, ML Bell, MT Salam, MW Gillman, N Gouveia, N Krieger, N Krieger, N Krieger, N Krieger, N Krieger, N Schenker, NA Ponce, RC Gwynn, RM Burton, S Kanjilal, S Macintyre, Steve J Melly, SV Subramanian, TIGER, TJ Woodruff, X Wang, Y Zhu   +50 more
core   +3 more sources

Prenatal Opioid Exposure: Neurodevelopmental Consequences and Future Research Priorities

Pediatrics, 2019
We provide a concise review of the neurodevelopmental consequences of prenatal opioid exposure and an agenda for future research, addressing extant methodologic shortcomings. Neonatal opioid withdrawal syndrome (NOWS) has risen in prevalence from 1.2 per
Elisabeth Conradt, Tess Flannery, J. Aschner, R. Annett, L. Croen, C. Duarte, A. Friedman, C. Guille, Monique M. Hedderson, J. Hofheimer, Miranda R. Jones, C. Ladd-Acosta, M. McGrath, A. Moreland, J. Neiderhiser, R. Nguyen, J. Posner, Judith L. Ross, D. Savitz, S. Ondersma, B. Lester   +20 more
semanticscholar   +1 more source

Prenatal Evaluation of RNU4‐2 Variants in Fetuses With Central Nervous System Anomalies

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Fetal central nervous system (CNS) anomalies are among the most common congenital malformations, yet the overall prenatal diagnostic yield of current genetic testing remains below 40%. Variants in RNU4‐2, a non‐coding gene encoding the U4 small nuclear RNA (snRNA), have recently been linked to a novel highly recurrent dominant ...
Yiyao Chen, Li Gao, Xu Han, Yunyun Cao, Lanlan Zhang, Yi Wu, Xinrong Zhao, Wenjing Hu, Ruiyu Ma, Renyi Hua, Niu Li, Yanlin Wang, Jian Wang, Shuyuan Li   +13 more
wiley   +1 more source

Involvement of the CXCL12 System in the Stimulatory Effects of Prenatal Exposure to High-Fat Diet on Hypothalamic Orexigenic Peptides and Behavior in Offspring

Frontiers in Behavioral Neuroscience, 2017
Exposure to a high fat diet (HFD) during gestation stimulates neurogenesis and expression of hypothalamic orexigenic neuropeptides that affect consummatory and emotional behaviors.
Kinning Poon, Jessica R. Barson, Jessica R. Barson, Huanzhi Shi, Guo Qing Chang, Sarah F. Leibowitz   +5 more
doaj   +1 more source

Early-Life Air Pollution Exposure, Neighborhood Poverty, and Childhood Asthma in the United States, 1990⁻2014. [PDF]

, 2018
Ambient air pollution is a well-known risk factor of various asthma-related outcomes, however, past research has often focused on acute exacerbations rather than asthma development.
Crowder, Kyle, Hajat, Anjum, Kravitz-Wirtz, Nicole, Takeuchi, David, Teixeira, Samantha, Woo, Bongki   +5 more
core   +3 more sources