Results 81 to 90 of about 2,600,864 (356)

PFOS Disrupts Oocyte Maturation and Early Embryonic Development via Ovarian FOXK1 O‐GlcNAcylation in Mice

Advanced Science, EarlyView.
Perfluorooctane sulfonate (PFOS) exposure disrupts oocyte maturation and early embryonic development. This study elucidates the mechanism by which enhanced O‐GlcNAcylation of FOXK1 underlies the PFOS‐induced reduction of progesterone levels in granulosa cells and the disturbance of follicular microenvironment.
Shuwen Han, Qin Yuan, Zhu Wu, Yaohui Fang, Hong Qian, Jiale Zhu, Yuchen Zhang, Ke Deng, Liangliang Su, Haibo Xu, Haotian Shu, Yiming Gong, Qiaoqiao Xu, Guizhen Du, Di Wu, Yun Fan, Chuncheng Lu   +16 more
wiley   +1 more source

DNA methylation at GRIN2B partially mediates the association between prenatal bisphenol F exposure and cognitive functions in 7-year-old children in the SELMA study

Environment International, 2021
Background: Accumulating evidence suggests that prenatal chemical exposure triggers epigenetic modifications that could influence health outcomes later in life.
Elin Engdahl, Katherine Svensson, Ping-I Daniel Lin, Ali Alavian-Ghavanini, Christian Lindh, Joëlle Rüegg, Carl-Gustaf Bornehag   +6 more
doaj   +1 more source

Estimated daily phthalate exposures in a population of mothers of male infants exhibiting reduced anogenital distance. [PDF]

, 2006
Phthalate diesters have been shown to be developmental and reproductive toxicants in animal studies. A recent epidemiologic study showed certain phthalates to be significantly associated with reduced anogenital distance in human male infants, the first ...
Axelrad, Daniel, Calafat, Antonia, Marsee, Kevin, Swan, Shanna, Woodruff, Tracey   +4 more
core   +2 more sources

Fetal Alcohol Spectrum Disorders: A Review of the Neurobehavioral Deficits Associated With Prenatal Alcohol Exposure.

Alcoholism: Clinical and Experimental Research, 2019
In utero alcohol exposure can disrupt the development of the fetal brain and result in a wide range of neurobehavioral outcomes collectively known as fetal alcohol spectrum disorders (FASD). This paper provides a comprehensive review of the cognitive and
S. Mattson, Gemma A Bernes, Lauren R. Doyle   +2 more
semanticscholar   +1 more source

Prenatal opioid exposure is associated with smaller brain volumes in multiple regions

Pediatric Research, 2020
The impact of prenatal opioid exposure on brain development remains poorly understood. We conducted a prospective study of term-born infants with and without prenatal opioid exposure.
S. Merhar, J. Kline, A. Braimah, Beth Kline-Fath, Jean A. Tkach, M. Altaye, Lili He, N. Parikh   +7 more
semanticscholar   +1 more source

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

Prenatal exposure to organochlorine compounds and lung function during childhood

Environment International, 2019
Introduction: Prenatal exposure to organochlorine compounds (OCs) can increase the risk of reported respiratory symptoms in children. It remains unclear whether these compounds can also impact on lung function.
Alicia Abellan, Jordi Sunyer, Raquel Garcia-Esteban, Mikel Basterrechea, Talita Duarte-Salles, Amparo Ferrero, Judith Garcia-Aymerich, Mireia Gascon, Joan O. Grimalt, Maria-Jose Lopez-Espinosa, Carlos Zabaleta, Martine Vrijheid, Maribel Casas   +12 more
doaj   +1 more source

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source

Antibiotic use during pregnancy and neurodevelopmental outcomes of offspring in early childhood [PDF]

, 2020
There is limited research on the effects of antibiotic use during pregnancy on neurodevelopmental outcomes of offspring in early childhood. The aim of this study was to investigate associations between antibiotic use during early pregnancy and ...
Gamache, Tressa
core  

Prenatal and infant exposure to ambient pesticides and autism spectrum disorder in children: population based case-control study

British medical journal, 2019
Objective To examine associations between early developmental exposure to ambient pesticides and autism spectrum disorder. Design Population based case-control study.
O. V. von Ehrenstein, Chenxiao Ling, X. Cui, M. Cockburn, Andrew S Park, Fei Yu, Jun Wu, B. Ritz   +7 more
semanticscholar   +1 more source