Results 31 to 40 of about 10,921,254 (269)

Expanding Genetic Code to Generate Human Brain Organoids with Both Vasculature and Microglia‐Like Cells

Advanced Science, EarlyView.
Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin, Yaqing Wang, Hu Du, Yuxin Qin, Haoyu Zhang, Peng Wang, Lin Wei, Jianhua Qin   +7 more
wiley   +1 more source

Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers

Clinics, 2011
INTRODUCTION: Prenatal tobacco exposure interferes with neonatal outcomes. OBJECTIVE: To determine the neonatal neurobehavioral effects of in utero tobacco exposure.
Marina C. M. Barros, Sandro S Mitsuhiro, Elisa Chalem, Ronaldo R Laranjeira, Ruth Guinsburg   +4 more
doaj   +1 more source

Long-term prenatal stress increases susceptibility of N-methyl-D-aspartic acid-induced spasms in infant rats [PDF]

Korean Journal of Pediatrics, 2018
PurposeInfantile spasms, also known as West syndrome, is an age-specific epileptic seizure. Most patients with this condition also exhibit delayed development.
Hyeok Hee Kwon, Taekwan Lee, Jinpyo Hong, Dong Woon Kim, Joon Won Kang   +4 more
doaj   +1 more source

Childhood Effects of Prenatal and Postnatal Exposure to Mercurial Skin Lightening Agents. Literature Review

International Journal of Medical Students, 2022
Children's exposure to mercurial skin lightening agents at any time during their development, from intra-uterine to early developmental life, can lead to severe detrimental health effects.
Rebecca Murerwa, Fidel Gwala, Thomas Amuti, Mary Muange   +3 more
doaj   +1 more source

Preterm birth and small for gestational age in relation to alcohol consumption during pregnancy: stronger associations among vulnerable women? Results from two large Western-European studies [PDF]

, 2013
Pfinder M, Kunst AE, Feldmann R, van Eijsden M, Vrijkotte TGM. Preterm birth and small for gestational age in relation to alcohol consumption during pregnancy: stronger associations among vulnerable women? Results from two large Western-European studies.
van Eijsden, M., Feldmann, R., Kunst, A.E., Kunst, Anton E, van Eijsden, Manon, Tanja G M Vrijkotte, Anton E Kunst, Feldmann, Reinhold, Kunst, Anton E., Vrijkotte, Tanja G. M., Reinhold Feldmann, Pfinder, Manuela, Pfinder, M., Vrijkotte, T.G.M., Manuela Pfinder, Manon van Eijsden   +15 more
core   +2 more sources

Ciliary Membrane Lipid Homeostasis in Health and Disease

Advanced Science, EarlyView.
This review systematically delineates the distinct lipid landscapes of ciliary membranes, including the spatial organization of phosphoinositides, cholesterol, and sphingolipids. It elucidates how these lipids orchestrate ciliogenesis, signal transduction, and membrane dynamics in cilia beating, and highlights how their dysregulation drives ...
Zhenzhou Huang, Yuan‐yuan Liu, Hanqi Sun, Peiwei Liu   +3 more
wiley   +1 more source

A Scoping Review of the Relationship Between Maternal BMI and Offspring Incidence of Respiratory Infection: Where Do We Go From Here?

AJPM Focus
Introduction: Pregnancy complications, including high maternal BMI, are associated with altered early development and child health outcomes. A growing body of work links the prenatal environment, specifically maternal BMI, with respiratory infections in ...
Anastasia V. Warmington, RN, MSc, Dawn M.E. Bowdish, PhD, Diana Sherifali, RN, PhD, CDE, Deborah M. Sloboda, PhD   +3 more
doaj   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Differential effects of prenatal alcohol exposure on brain growth reveals early upregulation of cell cycle and apoptosis and delayed downregulation of metabolism in affected offspring

PLOS ONE
Fetal Alcohol Spectrum Disorder (FASD) encompasses the deleterious consequences of Prenatal Alcohol Exposure (PAE), including developmental delay, microcephaly, dysmorphologies, and cognitive and behavioral issues. The dose and timing of alcohol exposure, maternal and environmental factors, and genetics all impact FASD outcomes, but differential ...
Danielle Sambo, Ethan Kinstler, Yuhong Lin, David Goldman   +3 more
openaire   +3 more sources

An Adult Presentation of KIF11‐Related MCLID Syndrome: Case Report and 40‐Year Follow‐Up

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Pathogenic variants in KIF11 are linked to autosomal dominant syndromes with microcephaly, chorioretinopathy, lymphedema, and intellectual disability (MCLID), though adult presentations remain underreported. We report a 42‐year‐old female presenting with a de novo single‐amino acid in‐frame deletion in the KIF11 gene (c.1294_1296del; p ...
Thrishna Chathurvedula, Juvy Rabelas, Kareem Touleimat, Elaine Marchi, Ruhi Shah, Shaydah Kheradmand, Kuldeep Singh, Karen Amble, Gholson J. Lyon   +8 more
wiley   +1 more source