Results 61 to 70 of about 30,102 (276)

Prenatal exposure to adverse life events and autism and autistic‐like traits in children in the Norwegian Mother, Father and Child Cohort Study (MoBa)

JCPP Advances
Background Mothers' experience of adverse life events (ALEs, e.g., divorce, bereavement, injury) during pregnancy has been linked with neurodevelopmental conditions like autism, and related traits like social communication difficulties and repetitive ...
Aleksandra Kanina, Arvid Sjölander, Miriam I. Martini, Agnieszka Butwicka, Henrik Larsson, Amanda M. Hughes, Márta K. Radó, Mark J. Taylor, Alexandra Havdahl, Helga Ask, Mina A. Rosenqvist   +10 more
doaj   +1 more source

Identification of major congenital malformations based on healthcare databases in France: A proof‐of‐concept study using the epi‐meres nationwide mother–child register

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Besides registries, healthcare databases can provide useful information for assessing the frequency of major congenital malformations (MCMs) and investigating their risk factors, particularly medication exposures. This study aimed to assess the validity of MCMs identification based on French national, comprehensive healthcare databases ...
Tom Duchemin, Lise Marty, Jérôme Drouin, Sara Miranda, Jérémie Botton, Valérie Olié, Alain Weill, Rosemary Dray‐Spira   +7 more
wiley   +1 more source

Chronic Stress Alters Behavior in the Forced Swim Test and Underlying Neural Activity in Animals Exposed to Alcohol Prenatally: Sex- and Time-Dependent Effects

Frontiers in Behavioral Neuroscience, 2018
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) stress response has been suggested to play a role in vulnerability to stress-related disorders, such as depression.
Vivian Y. Y. Lam, Charlis Raineki, Lily E. Takeuchi, Linda Ellis, Todd S. Woodward, Todd S. Woodward, Joanne Weinberg   +6 more
doaj   +1 more source

Pathophysiology of polycystic ovary syndrome revisited: Current understanding and perspectives regarding future research

Reproductive Medicine and Biology, 2022
Background Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive‐age women and has lifelong effects on health. Methods In this review, I discuss the pathophysiology of PCOS. First, I summarize our current understanding
Miyuki Harada
doaj   +1 more source

Low-level prenatal lead exposure and infant sensory function [PDF]

, 2016
Background Lead is a pervasive neurotoxicant that has been associated with poorer cognitive, behavioral, and motor outcomes in children. The effects of lead on sensory function have not been well characterized.
Liu, Yuhe, Li, Ming, Ming Li, Li, Xiaoqing, Betsy Lozoff, Tardif, Twila, Silver, Monica K., Yuhe Liu, Niko Kaciroti, Meeker, John D., Silver, Monica K, Mai, Xiaoqin, Xiaoqin Mai, Paul Kileny, Kaciroti, Niko, Twila Tardif, John D. Meeker, Lozoff, Betsy, Meeker, John D, Monica K. Silver, Xiaoqing Li, Kileny, Paul   +21 more
core   +1 more source

On the importance of including both sexes in animal studies – insights from home‐cage monitoring

Biological Reviews, EarlyView.
ABSTRACT A review of behavioural studies using home‐cage monitoring (HCM) systems revealed that over 61% of studies used only male subjects, with only 24% including both sexes, despite evidence of substantial behavioural differences between male and female animals. This bias could influence the outcomes of biomedical research.
Maša Čater, Adam Dušek, Aleksandra Bartelik, Silvia Mandillo, Elisabetta Golini, Mara Rigamonti, Rasneer Sonia Bains, Hamish Forrest, Marion Rivalan, Melissa Long, Anna Kiryk, Lars Lewejohann, Nuno Henrique Franco   +12 more
wiley   +1 more source

Early cerebrovascular and parenchymal events following prenatal exposure to the putative neurotoxin methylazoxymethanol

Neurobiology of Disease, 2007
One of the most common causes of neurological disabilities are malformations of cortical development (MCD). A useful animal model of MCD consists of prenatal exposure to methylazoxymethanol (MAM), resulting in a postnatal phenotype characterized by ...
Stefania Bassanini, Kerri Hallene, Giorgio Battaglia, Adele Finardi, Stefano Santaguida, Marilyn Cipolla, Damir Janigro   +6 more
doaj   +1 more source

Prenatal Exposure to an EDC Mixture, NeuroMix: Effects on Brain, Behavior, and Stress Responsiveness in Rats

, 2022
Humans and wildlife are exposed to endocrine-disrupting chemicals (EDCs) throughout their lives. Environmental EDCs are implicated in a range of diseases/disorders with developmental origins, including neurodevelopment and behavior.
Tatum Moore, Matthew J. Groom, Lindsay M. Thompson, Andrea C. Gore   +3 more
core   +1 more source

A White Paper on Advancing Long‐Acting Therapeutics for Maternal and Pediatric Health by Bridging Gaps in Clinical Research, Access and Regulation

Clinical Pharmacology &Therapeutics, EarlyView.
As use cases for long‐acting therapeutics expand across clinical indications, there is a critical need to ensure the inclusion of women who are pregnant or breastfeeding, infants and children—populations with a historical gap in the availability of interventions already approved for use in adults.
Moherndran Archary, Robert Bies, Osei Boateng, Rachel Daley, Pierre Gashema, Mili Karina, Emily Njuguna, Sharon Nachman, Nathaniel Nkrumah, Carolyne Odula, Andrew Owen, Ethel D. Weld, Prajith Venkatasubramanian, Adeniyi Olagunju, on behalf of the Community of Practice for Long‐acting Therapeutics for Maternal and Paediatric Health, Rana Abutaima, Dorothy Akongo, Abdulnaser Alsharaa, Moherndran Archary, Shakir Atoyebi, Benoit Bestgen, Robert Bies, Osei Boateng, Andrew Butler, Edmund Capparelli, Rachel Daley, Layla Davies, Joelle Dountio, Henry Enzama, Pierre Gashema, Katila George, Dan Hawcutt, Rene Holm, Patrick Gad Iradukunda, Elodie Jambert, Mili Karina, Linda Lewis, Grace Miheso, Sebastien Morin, Andrew Morrison, Sharon Nachman, Shadia Nakalema, Emily Njunga, Nathaniel Nkrumah, Carolyne Odula‐Obonyo, Brenda Okware, Adeniyi Olagunju, Andrew Owen, Martina Penazzato, Natella Rakhmanina, Mphako Brighton Ratlabyana, Rachel Scott, Kimberly Struble, Andre‐Marie Tchouatieu, Catherine Unsworth, Prajith Venkatasubramanian, Catriona Waitt, Ethel Weld, Janine Winterbottom, Leena Zino   +59 more
wiley   +1 more source

Inhibition of BET proteins modulates amyloid-beta accumulation and cognitive performance in middle-aged mice prenatally exposed to maternal immune activation

Frontiers in Molecular Neuroscience
IntroductionGiven the complex etiological basis of Alzheimer’s disease (AD), it is reasonable to hypothesize that neuronal dysfunction and death result from the interplay of numerous factors, both genetic and environmental.
Marta Matuszewska, Anna Wilkaniec, Magdalena Gąssowska-Dobrowolska, Magdalena Cieślik, Gabriela Olech-Kochańczyk, Ewelina Pałasz, Elżbieta Gawinek, Marcin Strawski, Grzegorz A. Czapski   +8 more
doaj   +1 more source