Results 51 to 60 of about 2,233,310 (227)

The early-life exposome and epigenetic age acceleration in children

Environment International, 2021
The early-life exposome influences future health and accelerated biological aging has been proposed as one of the underlying biological mechanisms. We investigated the association between more than 100 exposures assessed during pregnancy and in childhood
Paula de Prado-Bert, Carlos Ruiz-Arenas, Marta Vives-Usano, Sandra Andrusaityte, Solène Cadiou, Ángel Carracedo, Maribel Casas, Leda Chatzi, Payam Dadvand, Juan R. González, Regina Grazuleviciene, Kristine B. Gutzkow, Line S. Haug, Carles Hernandez-Ferrer, Hector C. Keun, Johanna Lepeule, Léa Maitre, Rosie McEachan, Mark J. Nieuwenhuijsen, Dolors Pelegrí, Oliver Robinson, Rémy Slama, Marina Vafeiadi, Jordi Sunyer, Martine Vrijheid, Mariona Bustamante   +25 more
doaj   +1 more source

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

Prenatal tobacco and alcohol exposure, white matter microstructure, and early language skills in toddlers from a South African birth cohort

Frontiers in Integrative Neuroscience
IntroductionTobacco and alcohol are the two most common substances used during pregnancy, and both can disrupt neurodevelopment, resulting in cognitive and behavioral deficits including language difficulties.
Chloe Scholten, Chloe Scholten, Mohammad Ghasoub, Mohammad Ghasoub, Bryce Geeraert, Bryce Geeraert, Shantanu Joshi, Shantanu Joshi, Catherine J. Wedderburn, Catherine J. Wedderburn, Annerine Roos, Annerine Roos, Annerine Roos, Sivenesi Subramoney, Nadia Hoffman, Katherine Narr, Katherine Narr, Roger Woods, Roger Woods, Roger Woods, Roger Woods, Heather J. Zar, Heather J. Zar, Dan J. Stein, Dan J. Stein, Dan J. Stein, Kirsten Donald, Kirsten Donald, Catherine Lebel, Catherine Lebel, Catherine Lebel   +30 more
doaj   +1 more source

Epigenetic Predictors of Smoking: External Validation and Association With Smoking‐Related Cancer Risk

International Journal of Cancer, EarlyView.
ABSTRACT Tobacco smoking has a strong influence on DNA methylation (DNAm), enabling the development of DNAm‐based smoking predictors, yet external evaluations of these have remained limited. We aimed to assess six DNAm‐based smoking predictors in a large sample of middle‐aged and older Australians for (i) their accuracy and reliability, and (ii) their ...
Xiaoyu Fan, Danmeng Lily Li, Allison M. Hodge, Julie K. Bassett, Nina Afshar, Melissa C. Southey, Graham G. Giles, Roger L. Milne, Pierre‐Antoine Dugué   +8 more
wiley   +1 more source

Prenatal, infantile, and childhood tobacco exposure and risk of pediatric psoriasis in the Danish National Birth Cohort offspring

, 2020
BACKGROUND: Tobacco smoking is implicated in psoriasis among adults.OBJECTIVE: To determine whether prenatal, infantile, and childhood tobacco exposure increase risk of pediatric psoriasis.METHODS: Data from Danish National Birth Cohort participants were
Nybo Andersen, Anne-Marie, Pinot de Moira, Angela, Blegvad, Christoffer, Skov, Lone, Groot, Jonathan   +4 more
core   +1 more source

Risk factors for intrapartum stillbirth and the survival probabilities of fetuses among pregnant women with complications: Secondary analysis of data from a multicenter prospective cohort study in India

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To identify the risk factors for intrapartum stillbirth and examine whether these are different from that of antepartum stillbirth, and investigate the survival probabilities of fetuses by gestational age in high‐risk pregnancies. Methods We conducted a secondary data analysis of a hospital‐based cohort study from India, including ...
Yebeen Ysabelle Boo, Saswati S. Choudhury, Farzana Zahir, Gitanjali Deka, Amrit K. Bora, Shakuntala Chhabra, Pramod Kumar, Pranabika Mahanta, Bina Minz, Anjali Rani, Sereesha Rao, Indrani Roy, Carolin Solomi V., Ashok Verma, Swapna Kakoty, Omesh Kumar Bharti, Rupanjali Deka, Charles Opondo, Tuck Seng Cheng, Jennifer J. Kurinczuk, Manisha Nair, on behalf of the MaatHRI collaborators   +21 more
wiley   +1 more source

Executive function and cortical thickness in youths prenatally exposed to cocaine, alcohol and tobacco

Developmental Cognitive Neuroscience, 2015
Small and detrimental, albeit inconsistent, effects of prenatal cocaine exposure (PCE) during early childhood have been reported. The teratogenic effects of prenatal alcohol (PAE) and tobacco exposure (PTE) on neurobehavior are more firmly established ...
Prapti Gautam, Tamara D. Warner, Eric C. Kan, Elizabeth R. Sowell   +3 more
doaj   +1 more source

Smoking behaviour, involuntary smoking, attitudes towards smoke-free legislations, and tobacco control activities in the European Union [PDF]

, 2010
The six most important cost-effective policies on tobacco control can be measured by the Tobacco Control Scale (TCS). The objective of our study was to describe the correlation between the TCS and smoking prevalence, self-reported exposure to secondhand ...
Martínez Sánchez, Jose M., Martínez Martínez, Cristina, La Vecchia, Carlo, Gallus, Silvano, Sureda, Xisca, Clancy, Luke, Fu Balboa, Marcela, Fernández Muñoz, Esteve, S. Gallus, Jose M. Martínez-Sánchez, Carlo La Vecchia, Xisca Sureda, La Vecchia Carlo, Clancy Luke, Luke Clancy, Martínez, Cristina, Silvano Gallus, Cristina Martínez, Marcela Fu, E. Fernández, Fu Marcela, J. M. Martínez Sánchez, C. La Vecchia, Sureda Xisca, Fernández, Esteve, Martínez Cristina, Gallus Silvano, Esteve Fernández, Fernández Esteve, L. Clancy, C. Martínez, Fu, Marcela, X. Sureda, Martínez-Sánchez Jose M., M. Fu, Jose M Martínez-Sánchez   +35 more
core   +1 more source

The womb as the cradle of longevity: Perinatal origins of biological aging

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract The perinatal period is increasingly recognized as an important determinant of biological aging trajectories and disease susceptibility across the lifespan. This narrative review synthesizes current evidence linking intrauterine exposures to adult health outcomes across three biological dimensions: fetal programming, maternal influences, and ...
Sevim Ozge Ozdemir, Ebru Davutoglu
wiley   +1 more source

Intersecting pathways of postpartum depressive symptoms and recurrent binge eating after gestational diabetes: Findings from the LINDA‐Brazil cohort

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To estimate the prevalence and correlates of recurrent binge eating (RBE) and postpartum depression (PPD), and examine their association among women with prior gestational diabetes mellitus (GDM). Methods This cross‐sectional analysis included 699 women with prior GDM who participated in the postpartum baseline assessment of the ...
Juliana Silvani, Lenita Zajdenverg, José Carlos Appolinario, Maria Inês Schmidt, Paula Andreghetto Bracco, Maria Angélica Antunes Nunes   +5 more
wiley   +1 more source