Results 171 to 180 of about 36,883 (221)
Prenylation inhibitors in renal disease
The Lancet, 2000 Members of the superfamily of Ras GTPase signalling proteins (monomeric G proteins) require post-translational carboxy-terminal prenylation to function. Prenylation is the covalent attachment of a hydrophobic prenyl group (either farnesyl or geranylgeranyl), which localises the GTPase to cell membranes.
Khwaja, A, Connolly, J O, Hendry, B M
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Catalytic prenylation and reverse prenylation of aromatics
Trends in Chemistry, 2022Yan-Cheng Hu +2 more
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Prenylation: A Critical Step for Biomanufacturing of Prenylated Aromatic Natural Products
Journal of Agricultural and Food Chemistry, 2023Prenylated aromatic natural products (PANPs) have received much attention due to their biomedical benefits for human health. The prenylation of aromatic natural products (ANPs), which is mainly catalyzed by aromatic prenyltransferases (aPTs), contributes significantly to their structural and functional diversity by providing higher lipophilicity and ...
Ting An, Xudong Feng, Chun Li
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BioEssays, 1992
AbstractThe prenylated proteins represent a newly discovered class of post‐translationally modified proteins. The known prenylated proteins include the oncogene product p21ras and other low molecular weight GTP‐binding proteins, the nuclear lamins, and the γ subunit of the heterotrimeric G proteins.
M, Sinensky, R J, Lutz
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AbstractThe prenylated proteins represent a newly discovered class of post‐translationally modified proteins. The known prenylated proteins include the oncogene product p21ras and other low molecular weight GTP‐binding proteins, the nuclear lamins, and the γ subunit of the heterotrimeric G proteins.
M, Sinensky, R J, Lutz
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Inhibitors of prenyl transferases
Current Opinion in Oncology, 1997Because farnesylation of Ras is required for its cancer-causing activity, several classes of farnesyl transferase inhibitors have recently been developed as potential anticancer drugs. During the last 12 months, important advances have been made in this field.
S, Sebti, A D, Hamilton
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Prenylated Flavonoids: Pharmacology and Biotechnology
Current Medicinal Chemistry, 2005Within the flavonoid class of natural products the prenylated sub-class is quite rich in structural variety and pharmacological activity. In the last twenty years a huge number of new structures has been reported, mostly from Leguminosae and Moraceae, with few coming from other genera.
BOTTA, Bruno +4 more
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ChemInform Abstract: A STUDY OF DE‐O‐PRENYLATION OF O‐PRENYL‐ AND C‐PRENYL‐O‐PRENYLPOLYPHENOLS
Chemischer Informationsdienst, 1978AbstractDer Prenylether (Ia) wird in wäßrigem Morpholin zum Phenol (Ib) gespalten.
A. C. JAIN, D. K. TULI, A. KOHLI
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Zinc-Mediated Highly α-Regioselective Prenylation of Imines with Prenyl Bromide
Organic Letters, 2012A highly α-regioselective prenylation of imines has been successfully developed. The efficiency of this approach is confirmed by a wide range of imines including N- and C-aryl aldimines, N-alkyl aldimines, C-alkyl aldimines, and N- and C-aryl ketimines.
Li-Ming, Zhao +4 more
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Antigenic Prenylated Peptide Conjugates and Polyclonal Antibodies To Detect Protein Prenylation
Bioconjugate Chemistry, 2004Posttranslational modification of proteins with farnesyl and geranylgeranyl groups is a required modification for signaling proteins that includes the small GTPases in the Ras, Rho, and Rab families, heterotrimeric G proteins, and nuclear lamin proteins.
Xiao-hui, Liu +3 more
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Chemical & Engineering News Archive, 2011
A NEWLY DISCOVERED enzyme that fastens prenyl groups to peptides works in an unusual way, according to a research report ( J. Am. Chem. Soc., DOI: 10.1021/ja205458h ).
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A NEWLY DISCOVERED enzyme that fastens prenyl groups to peptides works in an unusual way, according to a research report ( J. Am. Chem. Soc., DOI: 10.1021/ja205458h ).
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