The mevalonate pathway in
Lipids in Health and Disease, 2011 The mevalonate pathway in human is responsible for the synthesis of cholesterol and other important biomolecules such as coenzyme Q, dolichols and isoprenoids.
Rauthan Manish, Pilon Marc
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Activation of the plant mevalonate pathway by extracellular ATP [PDF]
Nature Communications, 2022 Products of the mevalonate pathway support plant development. Here the authors show that the extracellular ATP receptor P2K1 phosphorylates mevalonate kinase and this affects the mevalonate pathway.
Sung-Hwan Cho +9 more
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Loss of HMG-CoA reductase in C. elegans causes defects in protein prenylation and muscle mitochondria. [PDF]
PLoS ONE, 2014 HMG-CoA reductase is the rate-limiting enzyme in the mevalonate pathway and the target of cholesterol-lowering statins. We characterized the C. elegans hmgr-1(tm4368) mutant, which lacks HMG-CoA reductase, and show that its phenotypes recapitulate that ...
Parmida Ranji +3 more
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Prostate Cancer and the Mevalonate Pathway. [PDF]
Int J Mol SciAntineoplastic therapies for prostate cancer (PCa) have traditionally centered around the androgen receptor (AR) pathway, which has demonstrated a significant role in oncogenesis. Nevertheless, it is becoming progressively apparent that therapeutic strategies must diversify their focus due to the emergence of resistance mechanisms that the tumor ...
Guerrero-Ochoa P +7 more
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MicroRNA-874 targets phosphomevalonate kinase and inhibits cancer cell growth via the mevalonate pathway [PDF]
Scientific Reports, 2022 The microRNA (miR) miR-874, a potential tumour suppressor, causes cell death via target gene suppression in various cancer types. Mevalonate pathway inhibition also causes cell death in breast cancer.
Alimasi Aersilan +18 more
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The Mevalonate Pathway Is Indispensable for Adipocyte Survival [PDF]
iScience, 2018 Summary: The mevalonate pathway is essential for the synthesis of isoprenoids and cholesterol. Adipose tissue is known as a major site for cholesterol storage; however, the role of the local mevalonate pathway and its synthesized isoprenoids remains ...
Yu-Sheng Yeh +12 more
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Mevalonate pathway in pancreatic ductal adenocarcinoma: Mechanisms driving metabolic and cellular plasticity [PDF]
Cancer Pathogenesis and TherapyThe mevalonate pathway plays a crucial role in the metabolic reprogramming of pancreatic ductal adenocarcinoma (PDAC), driving lipid biosynthesis, redox homeostasis, and oncogenic signaling, thereby sustaining tumor progression and therapeutic resistance.
Jenna N. Duttenhefner, Katie M. Reindl
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The mevalonate pathway contributes to breast primary tumorigenesis and lung metastasis [PDF]
Molecular OncologyThe mevalonate pathway plays an important role in breast cancer and other tumor types. However, many issues remain obscure as yet regarding its mechanism of regulation and action.
Javier Conde +6 more
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Anti-inflammatory effect of fluvastatin on polarized macrophages and its dependence on the mevalonate pathway [PDF]
Scientific ReportsThe study focuses on the effects of fluvastatin on immunomarkers of the M1 and M2 macrophages and its direct role in macrophage (M0) polarization. Moreover, it investigates the dependency of immunomodulatory properties of fluvastatin on the mevalonate ...
Barbora Muffova +5 more
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Genomic variations of the mevalonate pathway in porokeratosis
eLife, 2015 Porokeratosis (PK) is a heterogeneous group of keratinization disorders. No causal genes except MVK have been identified, even though the disease was linked to several genomic loci.
Zhenghua Zhang +24 more
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