Results 1 to 10 of about 21,930 (203)
The mevalonate pathway in
Lipids in Health and Disease, 2011 The mevalonate pathway in human is responsible for the synthesis of cholesterol and other important biomolecules such as coenzyme Q, dolichols and isoprenoids.
Rauthan Manish, Pilon Marc
doaj +3 more sources
Activation of the plant mevalonate pathway by extracellular ATP [PDF]
Nature Communications, 2022 Products of the mevalonate pathway support plant development. Here the authors show that the extracellular ATP receptor P2K1 phosphorylates mevalonate kinase and this affects the mevalonate pathway.
Sung-Hwan Cho +9 more
doaj +2 more sources
Targeting the Mevalonate Pathway in Cancer
Trends in Cancer, 2021 The mevalonate synthesis inhibitors, statins, are mainstay therapeutics for cholesterol management and cardiovascular health. Thirty years of research have uncovered supportive roles for the mevalonate pathway in numerous cellular processes that support oncogenesis, most recently macropinocytosis. Central to the diverse mechanisms of statin sensitivity
David Fruman, Dennis Juarez
exaly +5 more sources
The Mevalonate Pathway Is Indispensable for Adipocyte Survival [PDF]
iScience, 2018 Summary: The mevalonate pathway is essential for the synthesis of isoprenoids and cholesterol. Adipose tissue is known as a major site for cholesterol storage; however, the role of the local mevalonate pathway and its synthesized isoprenoids remains ...
Yu-Sheng Yeh +12 more
doaj +3 more sources
Prostate Cancer and the Mevalonate Pathway. [PDF]
Int J Mol SciAntineoplastic therapies for prostate cancer (PCa) have traditionally centered around the androgen receptor (AR) pathway, which has demonstrated a significant role in oncogenesis. Nevertheless, it is becoming progressively apparent that therapeutic strategies must diversify their focus due to the emergence of resistance mechanisms that the tumor ...
Guerrero-Ochoa P +7 more
europepmc +4 more sources
The Mevalonate Pathway in the Radiation Response of Cancer. [PDF]
Int J Radiat Oncol Biol PhysThe mevalonate (MVA) pathway plays a critical role in cholesterol biosynthesis, protein prenylation, and metabolic reprogramming, all of which contribute to cancer progression and therapy resistance. Targeting the MVA pathway with statins and other inhibitors has shown promise in preclinical studies; however, clinical outcomes remain controversial ...
Azizi L +4 more
europepmc +3 more sources
Genomic variations of the mevalonate pathway in porokeratosis
eLife, 2015 Porokeratosis (PK) is a heterogeneous group of keratinization disorders. No causal genes except MVK have been identified, even though the disease was linked to several genomic loci.
Zhenghua Zhang +24 more
doaj +3 more sources
Mevalonate pathway in pancreatic ductal adenocarcinoma: Mechanisms driving metabolic and cellular plasticity [PDF]
Cancer Pathogenesis and TherapyThe mevalonate pathway plays a crucial role in the metabolic reprogramming of pancreatic ductal adenocarcinoma (PDAC), driving lipid biosynthesis, redox homeostasis, and oncogenic signaling, thereby sustaining tumor progression and therapeutic resistance.
Jenna N. Duttenhefner, Katie M. Reindl
doaj +2 more sources
Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells
Cell Reports, 2019 Summary: The function of regulatory T (Treg) cells depends on lipid oxidation. However, the molecular mechanism by which Treg cells maintain lipid metabolism after activation remains elusive.
Maheshwor Timilshina +18 more
doaj +3 more sources
The mevalonate pathway contributes to breast primary tumorigenesis and lung metastasis [PDF]
Molecular OncologyThe mevalonate pathway plays an important role in breast cancer and other tumor types. However, many issues remain obscure as yet regarding its mechanism of regulation and action.
Javier Conde +6 more
doaj +2 more sources