Results 1 to 10 of about 22,865 (199)

Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells

Cell Reports, 2019
Summary: The function of regulatory T (Treg) cells depends on lipid oxidation. However, the molecular mechanism by which Treg cells maintain lipid metabolism after activation remains elusive.
Yeonseok Chung, Mahesh Raj Nepal, Hyeun Wook Chang   +2 more
exaly   +3 more sources

Mevalonate pathway in pancreatic ductal adenocarcinoma: Mechanisms driving metabolic and cellular plasticity [PDF]

Cancer Pathogenesis and Therapy
The mevalonate pathway plays a crucial role in the metabolic reprogramming of pancreatic ductal adenocarcinoma (PDAC), driving lipid biosynthesis, redox homeostasis, and oncogenic signaling, thereby sustaining tumor progression and therapeutic resistance.
Jenna N. Duttenhefner, Katie M. Reindl
doaj   +2 more sources

The mevalonate pathway contributes to breast primary tumorigenesis and lung metastasis [PDF]

Molecular Oncology
The mevalonate pathway plays an important role in breast cancer and other tumor types. However, many issues remain obscure as yet regarding its mechanism of regulation and action.
Javier Conde, Isabel Fernández‐Pisonero, L. Francisco Lorenzo‐Martín, Rocío García‐Gómez, Berta Casar, Piero Crespo, Xosé R. Bustelo   +6 more
doaj   +2 more sources

Anti-inflammatory effect of fluvastatin on polarized macrophages and its dependence on the mevalonate pathway [PDF]

Scientific Reports
The study focuses on the effects of fluvastatin on immunomarkers of the M1 and M2 macrophages and its direct role in macrophage (M0) polarization. Moreover, it investigates the dependency of immunomodulatory properties of fluvastatin on the mevalonate ...
Barbora Muffova, Sona Kauerova, Karel Paukner, Hana Bartuskova, Rudolf Poledne, Ivana Kralova Lesna   +5 more
doaj   +2 more sources

Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis [PDF]

Cancer Cell, 2023
Rugang Zhang, Liao Liping
exaly   +2 more sources

Bacteroides sphingolipids promote anti-inflammatory responses through the mevalonate pathway [PDF]

Cell Host and Microbe
Ramnik J Xavier, Sarah Jeanfavre, Julian Avila-Pacheco   +2 more
exaly   +2 more sources

The mevalonate pathway promotes the metastasis of osteosarcoma by regulating YAP1 activity via RhoA

Genes and Diseases, 2022
Osteosarcoma is the most common malignant bone tumour, and the metastasis of osteosarcoma is an important cause of death. Evidence has shown that the mevalonate pathway is highly activated and is expected to be a new target for tumour therapy.
Xing Du, Yunsheng Ou, Muzi Zhang, Kai Li, Wei Huang, Dianming Jiang   +5 more
doaj   +1 more source

Activation of the plant mevalonate pathway by extracellular ATP

Nature Communications, 2022
Products of the mevalonate pathway support plant development. Here the authors show that the extracellular ATP receptor P2K1 phosphorylates mevalonate kinase and this affects the mevalonate pathway.
Sung-Hwan Cho, Katalin Tóth, Daewon Kim, Phuc H. Vo, Chung-Ho Lin, Pubudu P. Handakumbura, Albert Rivas Ubach, Sterling Evans, Ljiljana Paša-Tolić, Gary Stacey   +9 more
doaj   +1 more source

Glucose restriction drives spatial reorganization of mevalonate metabolism

eLife, 2021
Eukaryotes compartmentalize metabolic pathways into sub-cellular domains, but the role of inter-organelle contacts in organizing metabolic reactions remains poorly understood.
Sean Rogers, Hanaa Hariri, N Ezgi Wood, Natalie Ortiz Speer, W Mike Henne   +4 more
doaj   +1 more source

Evidence for an underestimation of the shunt pathway of mevalonate metabolism in slices of livers and kidneys from fasted rats and rats in diabetic ketosis

Journal of Lipid Research, 1982
Yields of (14)CO(2) from [2-(14)C]mevalonate and [5-(14)C]mevalonate have been used by others to estimate the activity of the non-sterol-forming pathway, also called the mevalonate shunt pathway, and yields of (14)C in sterols have been used to estimate ...
P S Brady, W C Schumann, S Ohgaku, R F Scofield, B R Landau   +4 more
doaj   +1 more source