Anti-inflammatory effect of fluvastatin on polarized macrophages and its dependence on the mevalonate pathway [PDF]
Scientific ReportsThe study focuses on the effects of fluvastatin on immunomarkers of the M1 and M2 macrophages and its direct role in macrophage (M0) polarization. Moreover, it investigates the dependency of immunomodulatory properties of fluvastatin on the mevalonate ...
Barbora Muffova +5 more
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Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis [PDF]
Cancer Cell, 2023 Rugang Zhang, Hao Nie
exaly +2 more sources
Bacteroides sphingolipids promote anti-inflammatory responses through the mevalonate pathway [PDF]
Cell Host and MicrobeJulian Avila, Ramnik Xavier
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The mevalonate pathway promotes the metastasis of osteosarcoma by regulating YAP1 activity via RhoA
Genes and Diseases, 2022 Osteosarcoma is the most common malignant bone tumour, and the metastasis of osteosarcoma is an important cause of death. Evidence has shown that the mevalonate pathway is highly activated and is expected to be a new target for tumour therapy.
Xing Du +5 more
doaj +1 more source
Biosynthesis of Abscisic Acid by the Non-mevalonate Pathway in Plants, and by the Mevalonate Pathway in Fungi [PDF]
Bioscience, Biotechnology, and Biochemistry, 2000 The biosynthetic pathways to abscisic acid (ABA) were investigated by feeding [1-(13)C]-D-glucose to cuttings from young tulip tree shoots and to two ABA-producing phytopathogenic fungi. 13C-NMR spectra of the ABA samples isolated showed that the carbons at 1, 5, 6, 4', 7' and 9' of ABA from the tulip tree were labeled with 13C, while the carbons at 2,
HIRAI, Nobuhiro +3 more
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Hepatology, EarlyView., 2022 Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince +30 more
wiley +1 more source
Glucose restriction drives spatial reorganization of mevalonate metabolism
eLife, 2021 Eukaryotes compartmentalize metabolic pathways into sub-cellular domains, but the role of inter-organelle contacts in organizing metabolic reactions remains poorly understood.
Sean Rogers +4 more
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Metabolites, 2020 The mevalonate pathway produces cholesterol and other compounds crucial for numerous cellular processes. It is well known that age and sex modulate this pathway in the liver.
Claudia Tonini +2 more
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Loss of HMG-CoA reductase in C. elegans causes defects in protein prenylation and muscle mitochondria. [PDF]
PLoS ONE, 2014 HMG-CoA reductase is the rate-limiting enzyme in the mevalonate pathway and the target of cholesterol-lowering statins. We characterized the C. elegans hmgr-1(tm4368) mutant, which lacks HMG-CoA reductase, and show that its phenotypes recapitulate that ...
Parmida Ranji +3 more
doaj +1 more source
Dysregulation of the mevalonate pathway promotes transformation [PDF]
Proceedings of the National Academy of Sciences, 2010 The importance of cancer metabolism has been appreciated for many years, but the intricacies of how metabolic pathways interconnect with oncogenic signaling are not fully understood. With a clear understanding of how metabolism contributes to tumorigenesis, we will be better able to integrate the targeting of these fundamental biochemical pathways into
James W, Clendening +10 more
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