Results 11 to 20 of about 22,865 (199)

The mevalonate pathway in C. Elegans [PDF]

Lipids in Health and Disease, 2011
The mevalonate pathway in human is responsible for the synthesis of cholesterol and other important biomolecules such as coenzyme Q, dolichols and isoprenoids.
Rauthan Manish, Pilon Marc
doaj   +3 more sources

The Mevalonate Pathway Is Indispensable for Adipocyte Survival [PDF]

iScience, 2018
Summary: The mevalonate pathway is essential for the synthesis of isoprenoids and cholesterol. Adipose tissue is known as a major site for cholesterol storage; however, the role of the local mevalonate pathway and its synthesized isoprenoids remains ...
Yu-Sheng Yeh, Huei-Fen Jheng, Mari Iwase, Minji Kim, Shinsuke Mohri, Jungin Kwon, Satoko Kawarasaki, Yongjia Li, Haruya Takahashi, Takeshi Ara, Wataru Nomura, Teruo Kawada, Tsuyoshi Goto   +12 more
doaj   +3 more sources

Genomic variations of the mevalonate pathway in porokeratosis

eLife, 2015
Porokeratosis (PK) is a heterogeneous group of keratinization disorders. No causal genes except MVK have been identified, even though the disease was linked to several genomic loci.
Zhenghua Zhang, Caihua Li, Fei Wu, Ruixiao Ma, Jing Luan, Feng Yang, Weida Liu, Li Wang, Shoumin Zhang, Yan Liu, Jun Gu, Wenlian Hua, Min Fan, Hua Peng, Xuemei Meng, Ningjing Song, Xinling Bi, Chaoying Gu, Zhen Zhang, Qiong Huang, Lianjun Chen, Leihong Xiang, Jinhua Xu, Zhizhong Zheng, Zhengwen Jiang   +24 more
doaj   +3 more sources

Prostate Cancer and the Mevalonate Pathway. [PDF]

Int J Mol Sci
Antineoplastic therapies for prostate cancer (PCa) have traditionally centered around the androgen receptor (AR) pathway, which has demonstrated a significant role in oncogenesis. Nevertheless, it is becoming progressively apparent that therapeutic strategies must diversify their focus due to the emergence of resistance mechanisms that the tumor ...
Guerrero-Ochoa P, Rodríguez-Zapater S, Anel A, Esteban LM, Camón-Fernández A, Espilez-Ortiz R, Gil-Sanz MJ, Borque-Fernando Á.   +7 more
europepmc   +4 more sources

Biosynthesis of Abscisic Acid by the Non-mevalonate Pathway in Plants, and by the Mevalonate Pathway in Fungi [PDF]

Bioscience, Biotechnology, and Biochemistry, 2000
The biosynthetic pathways to abscisic acid (ABA) were investigated by feeding [1-(13)C]-D-glucose to cuttings from young tulip tree shoots and to two ABA-producing phytopathogenic fungi. 13C-NMR spectra of the ABA samples isolated showed that the carbons at 1, 5, 6, 4', 7' and 9' of ABA from the tulip tree were labeled with 13C, while the carbons at 2,
HIRAI, Nobuhiro, YOSHIDA, Ryuji, TODOROKI, Yasushi, OHIGASHI, Hajime   +3 more
openaire   +2 more sources

The Mevalonate Pathway in the Radiation Response of Cancer. [PDF]

Int J Radiat Oncol Biol Phys
The mevalonate (MVA) pathway plays a critical role in cholesterol biosynthesis, protein prenylation, and metabolic reprogramming, all of which contribute to cancer progression and therapy resistance. Targeting the MVA pathway with statins and other inhibitors has shown promise in preclinical studies; however, clinical outcomes remain controversial ...
Azizi L, Hausman H, Meyer AK, Wong M, Pajonk F.   +4 more
europepmc   +3 more sources

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

Impact of Sex and Age on the Mevalonate Pathway in the Brain: A Focus on Effects Induced by Maternal Exposure to Exogenous Compounds

Metabolites, 2020
The mevalonate pathway produces cholesterol and other compounds crucial for numerous cellular processes. It is well known that age and sex modulate this pathway in the liver.
Claudia Tonini, Marco Segatto, Valentina Pallottini   +2 more
doaj   +1 more source

Loss of HMG-CoA reductase in C. elegans causes defects in protein prenylation and muscle mitochondria. [PDF]

PLoS ONE, 2014
HMG-CoA reductase is the rate-limiting enzyme in the mevalonate pathway and the target of cholesterol-lowering statins. We characterized the C. elegans hmgr-1(tm4368) mutant, which lacks HMG-CoA reductase, and show that its phenotypes recapitulate that ...
Parmida Ranji, Manish Rauthan, Christophe Pitot, Marc Pilon   +3 more
doaj   +1 more source

Dysregulation of the mevalonate pathway promotes transformation [PDF]

Proceedings of the National Academy of Sciences, 2010
The importance of cancer metabolism has been appreciated for many years, but the intricacies of how metabolic pathways interconnect with oncogenic signaling are not fully understood. With a clear understanding of how metabolism contributes to tumorigenesis, we will be better able to integrate the targeting of these fundamental biochemical pathways into
James W, Clendening, Aleks, Pandyra, Paul C, Boutros, Samah, El Ghamrasni, Fereshteh, Khosravi, Grace A, Trentin, Anna, Martirosyan, Anne, Hakem, Razqallah, Hakem, Igor, Jurisica, Linda Z, Penn   +10 more
openaire   +2 more sources