Results 1 to 10 of about 43,962 (233)
Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA
Acta Pharmaceutica Sinica B, 2023 Mevalonate metabolism plays an important role in regulating tumor growth and progression; however, its role in immune evasion and immune checkpoint modulation remains unclear.
wenxin Zhang, yanjun xu
exaly +3 more sources
Mevalonate Metabolism in Immuno-Oncology [PDF]
Frontiers in Immunology, 2017 Immuno-oncology not only refers to the multifaceted relationship between our immune system and a developing cancer but also includes therapeutic approaches that harness the body’s immune system to fight cancer.
Georg Gruenbacher, Martin Thurnher
doaj +3 more sources
Effect of mevalonate, zoledronate and BCG on monocyte/macrophage phenotype
Сибирский научный медицинский журнал, 2023 Cells of innate immunity, mainly monocytes/macrophages, form a long-term nonspecific immunological memory during the initial encounter with the pathogen, the so-called trained immunity.
A. P. Lykov +5 more
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Prospects for the use of statins in antiviral therapy [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2023 Inhibitors of hydroxymethylglutaryl-CoA reductase, in addition to suppressing cholesterol synthesis, have an antiviral effect. Clinical studies have shown antiviral efficacy of statins against COVID-19, HCV, HBV, RSV, HIV, influenza viruses.
Mustafin R.N.
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Frontiers in Pharmacology, 2020 Despite maximal use of currently available therapies, a significant number of asthma patients continue to experience severe, and sometimes life-threatening bronchoconstriction.
Robin A. Lu +9 more
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Glucose restriction drives spatial reorganization of mevalonate metabolism
eLife, 2021 Eukaryotes compartmentalize metabolic pathways into sub-cellular domains, but the role of inter-organelle contacts in organizing metabolic reactions remains poorly understood.
Sean Rogers +4 more
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Frontiers in Pharmacology, 2022 Background and aim: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease causing irreparable scarring of lung tissue, with most patients succumbing rapidly after diagnosis.
Lloyd Tanner +5 more
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c-Myc Sustains Pancreatic Cancer Cell Survival and mutp53 Stability through the Mevalonate Pathway
Biomedicines, 2022 It has been shown that wild-type (wt)p53 inhibits oncogene c-Myc while mutant (mut)p53 may transactivate it, with an opposite behavior that frequently occurs in the crosstalk of wt or mutp53 with molecules/pathways promoting carcinogenesis.
Maria Anele Romeo +5 more
doaj +1 more source
Journal of Lipid Research, 2003 Retention of LDL in the artery intima is mediated by extracellular matrix proteoglycans and plays an important role in the initiation of atherosclerosis.
C. Daniel Meyers +3 more
doaj +1 more source
Influx of cholesterol into plasma in rabbits with fasting hyperbetalipoproteinemia
Journal of Lipid Research, 1974 New Zealand white rabbits exhibited as much as a threefold increase in plasma cholesterol but no change in hepatic cholesterol when fasted for 7–9 days.
H.C. Klauda, D.B. Zilversmit
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