Results 1 to 10 of about 24,078 (213)
Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA
Acta Pharmaceutica Sinica B, 2023 Mevalonate metabolism plays an important role in regulating tumor growth and progression; however, its role in immune evasion and immune checkpoint modulation remains unclear.
Wenxin Zhang, Hongjie Guo
exaly +3 more sources
Hepatology, EarlyView., 2022 Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince +30 more
wiley +1 more source
Effect of mevalonate, zoledronate and BCG on monocyte/macrophage phenotype
Сибирский научный медицинский журнал, 2023 Cells of innate immunity, mainly monocytes/macrophages, form a long-term nonspecific immunological memory during the initial encounter with the pathogen, the so-called trained immunity.
A. P. Lykov +5 more
doaj +1 more source
Prospects for the use of statins in antiviral therapy [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2023 Inhibitors of hydroxymethylglutaryl-CoA reductase, in addition to suppressing cholesterol synthesis, have an antiviral effect. Clinical studies have shown antiviral efficacy of statins against COVID-19, HCV, HBV, RSV, HIV, influenza viruses.
Mustafin R.N.
doaj +1 more source
Frontiers in Pharmacology, 2020 Despite maximal use of currently available therapies, a significant number of asthma patients continue to experience severe, and sometimes life-threatening bronchoconstriction.
Robin A. Lu +9 more
doaj +1 more source
Glucose restriction drives spatial reorganization of mevalonate metabolism
eLife, 2021 Eukaryotes compartmentalize metabolic pathways into sub-cellular domains, but the role of inter-organelle contacts in organizing metabolic reactions remains poorly understood.
Sean Rogers +4 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Background and aim: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease causing irreparable scarring of lung tissue, with most patients succumbing rapidly after diagnosis.
Lloyd Tanner +5 more
doaj +1 more source
c-Myc Sustains Pancreatic Cancer Cell Survival and mutp53 Stability through the Mevalonate Pathway
Biomedicines, 2022 It has been shown that wild-type (wt)p53 inhibits oncogene c-Myc while mutant (mut)p53 may transactivate it, with an opposite behavior that frequently occurs in the crosstalk of wt or mutp53 with molecules/pathways promoting carcinogenesis.
Maria Anele Romeo +5 more
doaj +1 more source
The mevalonate pathway in C. elegans [PDF]
Lipids in Health and Disease, 2011 The mevalonate pathway in human is responsible for the synthesis of cholesterol and other important biomolecules such as coenzyme Q, dolichols and isoprenoids. These molecules are required in the cell for functions ranging from signaling to membrane integrity, protein prenylation and glycosylation, and energy homeostasis. The pathway consists of a main
Rauthan Manish, Pilon Marc
openaire +3 more sources
Journal of Lipid Research, 2003 Retention of LDL in the artery intima is mediated by extracellular matrix proteoglycans and plays an important role in the initiation of atherosclerosis.
C. Daniel Meyers +3 more
doaj +1 more source