Results 1 to 10 of about 30,985 (250)

Mechanisms and Predisposing Conditions for Statin-Induced New-Onset Type 2 Diabetes Mellitus: A Paradox Relative to Their Pleiotropic Metabolic Effects. [PDF]

Endocrinol Diabetes Metab
The primary function of statins is to inhibit cholesterol synthesis, which contributes to their antidiabetic effects. However, the majority of the diabetic effects of statins are due to inhibition of isoprenoid synthesis. Atorvastatin, simvastatin and rosuvastatin possess the most pronounced diabetogenic properties. In contrast, lovastatin, fluvastatin,
Andevari AN, Koolivand M.
europepmc   +2 more sources

RNA terminal uridylyl transferases are druggable vulnerabilities in AML but are dispensable for normal hematopoiesis. [PDF]

Sci Adv
Mapperley C, Georges E, Azar AA, Kabayama Y, Lawson H, Kucinski I, George D, Campos J, Fyfe C, Durko J, Chan WY, Allen L, Jazayeri B, Blacker E, van de Lagemaat LN, Tripp A, Roumeliotis TI, Guiducci G, Herbert E, Paris J, Choudhary J, Poulogiannis G, Campbell RM, Morgan M, Stojic L, Van Werven FJ, Vernimmen D, Göttgens B, O'Carroll D, Kranc KR.   +29 more
europepmc   +1 more source

Targeting the mevalonate pathway with statins overcomes acquired resistance to KRAS^G12C inhibitors in non-small cell lung cancer. [PDF]

Exp Hematol Oncol
Lin W, Chen QA, Yang Y, Gao Y, He J.
europepmc   +1 more source

Enhancing myrcene biosynthesis in yeast through nuclear compartmentalization. [PDF]

Synth Syst Biotechnol
Wang Z, Wang J, Liu Y, Chen M, Lu X, Xia Y, Xiao S, Tang H, Yang X, He Y.   +9 more
europepmc   +1 more source

Lipophilic Statins Deplete GPX4 to Promote Ferroptosis and Sensitize Cancer Cells to Immune Checkpoint Blockade. [PDF]

Mol Cancer Ther
Talty R, Brooks VT, McGeary MK, Milette S, Zheng S, Flem-Karlsen K, Daniels A, Deshmukh M, Park K, Caraccio W, Yan H, Echeandia-Francis C, McNamara M, Hong S, Kirwin DS, Olino K, Johnson CH, Bosenberg M, Micevic G, Roy SF.   +19 more
europepmc   +1 more source

Rewiring metabolic-immune circuitry in pancreatic ductal adenocarcinoma (PDAC). [PDF]

Cancer Pathog Ther
Yin X, Jin G.
europepmc   +1 more source

New Immunological Insights into Bisphosphonate-Related Osteonecrosis of the Jaw: A Multidimensional Reappraisal from Molecular Switches to Clinical Phenotypes. [PDF]

Curr Issues Mol Biol
Li Y, Qin S, Wang J, Shan Z, Song J, Zhang H, Pan W, Zhu Z.   +7 more
europepmc   +1 more source

DHX33 inhibitors induced transcriptional changes for a subset of genes in cancer cells. [PDF]

Sci Rep
Wang X, Fu Y, Tang X, Zhang Y.
europepmc   +1 more source

Commonly prescribed medicines antagonise anti-MRSA antibiotics and select for resistance. [PDF]

Microbiology (Reading)
Sohail Z, Claireaux HA, Edwards AM, Douglas EJA.   +3 more
europepmc   +1 more source

Mevalonic Acid Pyrophosphate and Isopentenylpyrophosphate

Journal of Biological Chemistry, 1959
K, BLOCH, S, CHAYKIN, A H, PHILLIPS, A, DE WAARD   +3 more
openaire   +2 more sources