Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA
Acta Pharmaceutica Sinica B, 2023 Mevalonate metabolism plays an important role in regulating tumor growth and progression; however, its role in immune evasion and immune checkpoint modulation remains unclear.
Wenxin Zhang, Hongjie Guo
exaly +3 more sources
Mevalonate Metabolism in Immuno-Oncology
Frontiers in Immunology, 2017 Immuno-oncology not only refers to the multifaceted relationship between our immune system and a developing cancer but also includes therapeutic approaches that harness the body’s immune system to fight cancer.
Georg Gruenbacher, Martin Thurnher
doaj +2 more sources
The Mevalonate Auxotrophic Mutant of Staphylococcus aureus Can Adapt to Mevalonate Depletion [PDF]
Antimicrobial Agents and Chemotherapy, 2013 ABSTRACT In this study, we attempted to adopt the auxotrophic mevalonate synthase mutant (Δ mvaS mutant) of Staphylococcus aureus to study whether a nongrowing but viable cell population is tolerant to bactericidal antibiotics. The mevalonate-depleted nongrowing Δ mvaS
Yu, Wenqi +5 more
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The Mevalonate Pathway: Innovations, Applications, and Challenges in Biotechnology with Emphasis on Fungal Biology [PDF]
Journal of FungiThe mevalonate (MVA) pathway is a central metabolic route responsible for the biosynthesis of isoprenoids with broad biological and biotechnological relevance.
Aisel Valle Garay +16 more
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The mevalonate pathway in C. elegans [PDF]
Lipids in Health and Disease, 2011 The mevalonate pathway in human is responsible for the synthesis of cholesterol and other important biomolecules such as coenzyme Q, dolichols and isoprenoids. These molecules are required in the cell for functions ranging from signaling to membrane integrity, protein prenylation and glycosylation, and energy homeostasis. The pathway consists of a main
Rauthan Manish, Pilon Marc
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Exploring the Isoprenoid Biosynthesis Pathway’s Role in Oncogenic Viruses [PDF]
VirusesOncogenic viruses, which are causative for some cancers, are typically acquired in youth and suppressed until older age. These malignancies account for over 10% of the cancer burden and often reprogram cellular metabolic pathways to promote their own ...
Louise N. Blaha +4 more
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Loss of HMG-CoA reductase in C. elegans causes defects in protein prenylation and muscle mitochondria. [PDF]
PLoS ONE, 2014 HMG-CoA reductase is the rate-limiting enzyme in the mevalonate pathway and the target of cholesterol-lowering statins. We characterized the C. elegans hmgr-1(tm4368) mutant, which lacks HMG-CoA reductase, and show that its phenotypes recapitulate that ...
Parmida Ranji +3 more
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Mechanisms underlying inflammation in mevalonate kinase deficiency [PDF]
Mevalonate kinase deficiency is an autoinflammatory metabolic disorder caused by biallelic pathogenic variants in the MVK gene characterized by lifelong recurring and often unprovoked episodes of inflammation.
Politiek, F.A.
core +7 more sources
Effect of mevalonate, zoledronate and BCG on monocyte/macrophage phenotype
Сибирский научный медицинский журнал, 2023 Cells of innate immunity, mainly monocytes/macrophages, form a long-term nonspecific immunological memory during the initial encounter with the pathogen, the so-called trained immunity.
A. P. Lykov +5 more
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Prospects for the use of statins in antiviral therapy [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2023 Inhibitors of hydroxymethylglutaryl-CoA reductase, in addition to suppressing cholesterol synthesis, have an antiviral effect. Clinical studies have shown antiviral efficacy of statins against COVID-19, HCV, HBV, RSV, HIV, influenza viruses.
Mustafin R.N.
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