Results 1 to 10 of about 9,848 (203)

Harnessing sub-organelle metabolism for biosynthesis of isoprenoids in yeast

Synthetic and Systems Biotechnology, 2020
Current yeast metabolic engineering in isoprenoids production mainly focuses on rewiring of cytosolic metabolic pathway. However, the precursors, cofactors and the enzymes are distributed in various sub-cellular compartments, which may hamper isoprenoid ...
Yongjin J Zhou, Chunyang Cao
exaly   +3 more sources

Protein engineering strategies for microbial production of isoprenoids

Metabolic Engineering Communications, 2020
Isoprenoids comprise one of the most chemically diverse family of natural products with high commercial interest. The structural diversity of isoprenoids is mainly due to the modular activity of three distinct classes of enzymes, including prenyl ...
Georgios Daletos, Gregory Stephanopoulos
exaly   +3 more sources

The Mevalonate Pathway: Innovations, Applications, and Challenges in Biotechnology with Emphasis on Fungal Biology. [PDF]

J Fungi (Basel)
The mevalonate (MVA) pathway is a central metabolic route responsible for the biosynthesis of isoprenoids with broad biological and biotechnological relevance.
Valle Garay A, Marques Coelho C, Fonseca Valadares N, Ferreira da Silva L, Sousa Cabral L, de Castro Leitão M, Piva LC, Lisboa De Marco J, Rabello de Camargo B, Araújo Souza A, Moreira de Oliveira IC, Schwartz MF, Godoy de Andrade TM, Souza Carmo T, Moreira de Almeida JR, Gonçalves Torres FA, de Freitas SM.   +16 more
europepmc   +2 more sources

Beyond cardiovascular protection: a conceptual and translational review of the hepato-specific mechanisms of statins in metabolic dysfunction-associated steatotic liver disease (MASLD). [PDF]

Front Pharmacol
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide, and cardiovascular disease remains the leading cause of death in this population.
Jiménez-González C, Iruzubieta P, Alonso-Peña M, Cayón L, Crespo J.   +4 more
europepmc   +2 more sources

Isoprenoid Metabolism and Engineering in Glandular Trichomes of Lamiaceae

Frontiers in Plant Science, 2021
The isoprenoids play important ecological and physiological roles in plants. They also have a tremendous impact on human lives as food additives, medicines, and industrial raw materials, among others. Though some isoprenoids are highly abundant in nature,
Soheil S. Mahmoud, Savanna Maddock, Ayelign M. Adal   +2 more
doaj   +1 more source

Soil uptake of isoprenoids in a Eucalyptus urophylla plantation forest in subtropical China

Frontiers in Forests and Global Change, 2023
The exchange of isoprenoids, which includes isoprene, monoterpenes, and sesquiterpenes, between ecosystem soils and the atmosphere plays a significant role in soil ecology and atmospheric chemistry. However, research on flux exchange rates in subtropical
Zhaobin Mu, Zhaobin Mu, Zhaobin Mu, Zhaobin Mu, Jianqiang Zeng, Jianqiang Zeng, Jianqiang Zeng, Yanli Zhang, Yanli Zhang, Wei Song, Wei Song, Weihua Pang, Weihua Pang, Weihua Pang, Zhigang Yi, Dolores Asensio, Dolores Asensio, Joan Llusià, Joan Llusià, Josep Peñuelas, Josep Peñuelas, Xinming Wang, Xinming Wang, Xinming Wang   +23 more
doaj   +1 more source

Antioxidants of Non-Enzymatic Nature: Their Function in Higher Plant Cells and the Ways of Boosting Their Biosynthesis

Antioxidants, 2023
Plants are exposed to a variety of abiotic and biotic stresses leading to increased formation of reactive oxygen species (ROS) in plant cells. ROS are capable of oxidizing proteins, pigments, lipids, nucleic acids, and other cell molecules, disrupting ...
Natalia N. Rudenko, Daria V. Vetoshkina, Tatiana V. Marenkova, Maria M. Borisova-Mubarakshina   +3 more
doaj   +1 more source

Combinatorial Engineering Enables Photoautotrophic Growth in High Cell Density Phosphite-Buffered Media to Support Engineered Chlamydomonas reinhardtii Bio-Production Concepts

Frontiers in Microbiology, 2022
Chlamydomonas reinhardtii has emerged as a powerful green cell factory for metabolic engineering of sustainable products created from the photosynthetic lifestyle of this microalga.
Malak N. Abdallah, Gordon B. Wellman, Sebastian Overmans, Kyle J. Lauersen   +3 more
doaj   +1 more source

Adaptation of hydroxymethylbutenyl diphosphate reductase enables volatile isoprenoid production

eLife, 2020
Volatile isoprenoids produced by plants are emitted in vast quantities into the atmosphere, with substantial effects on global carbon cycling. Yet, the molecular mechanisms regulating the balance between volatile and non-volatile isoprenoid production ...
Mareike Bongers, Jordi Perez-Gil, Mark P Hodson, Lars Schrübbers, Tune Wulff, Morten OA Sommer, Lars K Nielsen, Claudia E Vickers   +7 more
doaj   +1 more source

The Coordinated Upregulated Expression of Genes Involved in MEP, Chlorophyll, Carotenoid and Tocopherol Pathways, Mirrored the Corresponding Metabolite Contents in Rice Leaves during De-Etiolation

Plants, 2021
Light is an essential regulator of many developmental processes in higher plants. We investigated the effect of 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1/2 genes (OsHDR1/2) and isopentenyl diphosphate isomerase 1/2 genes (OsIPPI1/2) on the ...
Xin Jin, Can Baysal, Margit Drapal, Yanmin Sheng, Xin Huang, Wenshu He, Lianxuan Shi, Teresa Capell, Paul D. Fraser, Paul Christou, Changfu Zhu   +10 more
doaj   +1 more source