Results 21 to 30 of about 9,848 (203)

Farnesyltransferase Enables Modular Assembly of Dual‐Functional Nanobody Conjugates for in Vivo Imaging of Inflammation

Angewandte Chemie, EarlyView.
A modular farnesyltransferase‐based chemoenzymatic platform enables fast, site‐specific labeling of nanobodies for PET imaging of inflammation. CD11b‐targeted PET agents selectively image myeloid‐driven inflammation, while CD45‐targeted PET agents provide sensitive whole‐body immune mapping.
Sneha Venkatachalapathy, Yoon Ho Lee, Ali Salehi Farid, Heydar Moravej, Sina Djafari Rouhani, Jennifer E. Rowley, Mohammad Rashidian, Mark D. Distefano   +7 more
wiley   +2 more sources

Coenzyme Q10 Biosynthesis Established in the Non-Ubiquinone Containing Corynebacterium glutamicum by Metabolic Engineering

Frontiers in Bioengineering and Biotechnology, 2021
Coenzyme Q10 (CoQ10) serves as an electron carrier in aerobic respiration and has become an interesting target for biotechnological production due to its antioxidative effect and benefits in supplementation to patients with various diseases.
Arthur Burgardt, Ayham Moustafa, Marcus Persicke, Jens Sproß, Thomas Patschkowski, Joe Max Risse, Petra Peters-Wendisch, Jin-Ho Lee, Volker F. Wendisch   +8 more
doaj   +1 more source

Broad‐Spectrum, Cell Envelope‐Active Marinocyclin Antibiotics From a Coral‐Derived Bacterium Are Effective Against Colistin‐Resistant Bacteria

Angewandte Chemie, EarlyView.
Marinocyclins, polycationic macrocyclic depsipeptides, were discovered by genome mining from the marine coral‐derived bacterium Aquimarina megaterium. The compounds have broad‐spectrum activity against gram‐positive and gram‐negative ESKAPE bacteria.
Clara Chepkirui, Sandra Silva, Jan Straetener, Chandrashekhar Padhi, Tina Keller‐Costa, Tess Lamer, Laura Reinke, Heike Brötz‐Oesterhelt, Rodrigo Costa, Jörn Piel   +9 more
wiley   +2 more sources

Genetic Adaptation of a Mevalonate Pathway Deficient Mutant in Staphylococcus aureus

Frontiers in Microbiology, 2018
In this study we addressed the question how a mevalonate (MVA)-auxotrophic Staphylococcus aureusΔmvaS mutant can revert to prototrophy. This mutant couldn’t grow in the absence of MVA.
Sebastian Reichert, Patrick Ebner, Eve-Julie Bonetti, Arif Luqman, Mulugeta Nega, Jacques Schrenzel, Cathrin Spröer, Boyke Bunk, Jörg Overmann, Peter Sass, Patrice François, Friedrich Götz   +11 more
doaj   +1 more source

The isoprenoid alcohol pathway, a synthetic route for isoprenoid biosynthesis [PDF]

Proceedings of the National Academy of Sciences, 2019
Significance We have demonstrated the design, prototyping, and implementation of a non-natural route to isoprenoid biosynthesis, termed the isoprenoid alcohol (IPA) pathway. Opposed to working within the confines of native metabolic pathways, our approach of utilizing all available biochemical reactions identified a synthetic route to
James M, Clomburg, Shuai, Qian, Zaigao, Tan, Seokjung, Cheong, Ramon, Gonzalez   +4 more
openaire   +2 more sources

The Potential of Isoprenoids in Adjuvant Cancer Therapy to Reduce Adverse Effects of Statins

Frontiers in Pharmacology, 2019
The mevalonate pathway provides sterols for membrane structure and nonsterol intermediates for the post-translational modification and membrane anchorage of growth-related proteins, including the Ras, Rac, and Rho GTPase family.
Huanbiao Mo, Rayna Jeter, Andrea Bachmann, Sophie T. Yount, Chwan-Li Shen, Hoda Yeganehjoo   +5 more
doaj   +1 more source

A hypothesis on the capacity of plant odorant-binding proteins to bind volatile isoprenoids based on in silico evidences

eLife, 2021
Volatile organic compounds (VOCs) from ‘emitting’ plants inform the ‘receiving’ (listening) plants of impending stresses or simply of their presence. However, the receptors that allow receivers to detect the volatile cue are elusive. Most likely, plants (
Deborah Giordano, Angelo Facchiano, Sabato D'Auria, Francesco Loreto   +3 more
doaj   +1 more source

Mutant-Based Model of Two Independent Pathways for Carotenoid-Mediated Chloroplast Biogenesis in Arabidopsis Embryos

Frontiers in Plant Science, 2019
Chloroplasts are essential for autonomous plant growth, and their biogenesis is a complex process requiring both plastid and nuclear genome. One of the essential factors required for chloroplast biogenesis are carotenoids.
Eva Vranová, Diana Kopcsayová, Ján Košuth, Maite Colinas   +3 more
doaj   +1 more source

Lipidomics and Comparative Metabolite Excretion Analysis of Methanogenic Archaea Reveal Organism-Specific Adaptations to Varying Temperatures and Substrate Concentrations

mSystems, 2023
Methanogenic archaea possess diverse metabolic characteristics and are an ecologically and biotechnologically important group of anaerobic microorganisms.
Ruth-Sophie Taubner, Lydia M. F. Baumann, Michael Steiner, Kevin Pfeifer, Barbara Reischl, Kordian Korynt, Thorsten Bauersachs, Barbara Mähnert, Elisabeth L. Clifford, Jörn Peckmann, Bernhard Schuster, Daniel Birgel, Simon K.-M. R. Rittmann   +12 more
doaj   +1 more source

Microbial monoterpene transformations – A review

Frontiers in Microbiology, 2014
Isoprene and monoterpenes constitute a significant fraction of new plant biomass. Emission rates into the atmosphere alone are estimated to be over 500 Tg per year. These natural hydrocarbons are mineralized annually in similar quantities.
Robert eMarmulla, Jens eHarder
doaj   +1 more source