Results 31 to 40 of about 9,848 (203)

Current Metabolic Engineering Strategies for Photosynthetic Bioproduction in Cyanobacteria

Microorganisms, 2023
Cyanobacteria are photosynthetic microorganisms capable of using solar energy to convert CO2 and H2O into O2 and energy-rich organic compounds, thus enabling sustainable production of a wide range of bio-products.
Alessandro Satta, Lygie Esquirol, Birgitta E. Ebert   +2 more
doaj   +1 more source

Systems-Level Analysis of Oxygen Exposure in Zymomonas mobilis: Implications for Isoprenoid Production

mSystems, 2019
Zymomonas mobilis is an aerotolerant anaerobe and prolific ethanologen with attractive characteristics for industrial bioproduct generation. However, there is currently insufficient knowledge of the impact that environmental factors have on flux through ...
Julia I. Martien, Alexander S. Hebert, David M. Stevenson, Matthew R. Regner, Daven B. Khana, Joshua J. Coon, Daniel Amador-Noguez   +6 more
doaj   +1 more source

Hepatic CYP3A4 Enzyme Compensatively Maintains Endogenous Geranylgeranoic Acid Levels in MAOB-Knockout Human Hepatoma Cells

Metabolites, 2022
Geranylgeranoic acid (GGA), developed as a preventive agent against second primary hepatoma, has been reported to be biosynthesized via the mevalonate pathway in human hepatoma-derived cells.
Yuki Tabata, Yoshihiro Shidoji
doaj   +1 more source

Metallopeptidase Stp1 activates the transcription factor Sre1 in the carotenogenic yeast Xanthophyllomyces dendrorhous[S]

Journal of Lipid Research, 2020
Xanthophyllomyces dendrorhous is a basidiomycete yeast known as a natural producer of astaxanthin, a carotenoid of commercial interest because of its antioxidant properties. Recent studies indicated that X.
Melissa Gómez, María Soledad Gutiérrez, Ana María González, Carla Gárate-Castro, Dionisia Sepúlveda, Salvador Barahona, Marcelo Baeza, Víctor Cifuentes, Jennifer Alcaíno   +8 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Suppression of Drug Resistance Reveals a Genetic Mechanism of Metabolic Plasticity in Malaria Parasites

mBio, 2018
In the malaria parasite Plasmodium falciparum, synthesis of isoprenoids from glycolytic intermediates is essential for survival. The antimalarial fosmidomycin (FSM) inhibits isoprenoid synthesis. In P.
Ann M. Guggisberg, Philip M. Frasse, Andrew J. Jezewski, Natasha M. Kafai, Aakash Y. Gandhi, Samuel J. Erlinger, Audrey R. Odom John   +6 more
doaj   +1 more source

Sterol regulatory element-binding protein Sre1 regulates carotenogenesis in the red yeast Xanthophyllomyces dendrorhous

Journal of Lipid Research, 2020
Xanthophyllomyces dendrorhous is a basidiomycete yeast that produces carotenoids, mainly astaxanthin. Astaxanthin is an organic pigment of commercial interest due to its antioxidant and coloring properties. X.
Melissa Gómez, Sebastián Campusano, María Soledad Gutiérrez, Dionisia Sepúlveda, Salvador Barahona, Marcelo Baeza, Víctor Cifuentes, Jennifer Alcaíno   +7 more
doaj   +1 more source

Diversifying Isoprenoid Platforms via Atypical Carbon Substrates and Non-model Microorganisms

Frontiers in Microbiology, 2021
Isoprenoid compounds are biologically ubiquitous, and their characteristic modularity has afforded products ranging from pharmaceuticals to biofuels. Isoprenoid production has been largely successful in Escherichia coli and Saccharomyces cerevisiae with ...
David N. Carruthers, David N. Carruthers, Taek Soon Lee, Taek Soon Lee   +3 more
doaj   +1 more source

Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges

Advanced Science, EarlyView.
Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen, Bao Chen, Wenhui Zhang, Guifang Sun, Yao Zhao, Jianpeng Zhang, Baofu Xu   +6 more
wiley   +1 more source

Human Isoprenoid Synthase Enzymes as Therapeutic Targets

Frontiers in Chemistry, 2014
The complex biochemical network known as the mevalonate pathway is responsible for the biosynthesis of all isoprenoids in the human body, which consists of a vast array of metabolites that are vital for proper cellular functions.
Jaeok ePark, Alexios eMatralis, Albert M. Berghuis, Youla S Tsantrizos   +3 more
doaj   +1 more source