Results 41 to 50 of about 22,403 (243)

Metallopeptidase Stp1 activates the transcription factor Sre1 in the carotenogenic yeast Xanthophyllomyces dendrorhous[S]

Journal of Lipid Research, 2020
Xanthophyllomyces dendrorhous is a basidiomycete yeast known as a natural producer of astaxanthin, a carotenoid of commercial interest because of its antioxidant properties. Recent studies indicated that X.
Melissa Gómez, María Soledad Gutiérrez, Ana María González, Carla Gárate-Castro, Dionisia Sepúlveda, Salvador Barahona, Marcelo Baeza, Víctor Cifuentes, Jennifer Alcaíno   +8 more
doaj   +1 more source

Sterol regulatory element-binding protein Sre1 regulates carotenogenesis in the red yeast Xanthophyllomyces dendrorhous

Journal of Lipid Research, 2020
Xanthophyllomyces dendrorhous is a basidiomycete yeast that produces carotenoids, mainly astaxanthin. Astaxanthin is an organic pigment of commercial interest due to its antioxidant and coloring properties. X.
Melissa Gómez, Sebastián Campusano, María Soledad Gutiérrez, Dionisia Sepúlveda, Salvador Barahona, Marcelo Baeza, Víctor Cifuentes, Jennifer Alcaíno   +7 more
doaj   +1 more source

Diversifying Isoprenoid Platforms via Atypical Carbon Substrates and Non-model Microorganisms

Frontiers in Microbiology, 2021
Isoprenoid compounds are biologically ubiquitous, and their characteristic modularity has afforded products ranging from pharmaceuticals to biofuels. Isoprenoid production has been largely successful in Escherichia coli and Saccharomyces cerevisiae with ...
David N. Carruthers, David N. Carruthers, Taek Soon Lee, Taek Soon Lee   +3 more
doaj   +1 more source

Suppression of Drug Resistance Reveals a Genetic Mechanism of Metabolic Plasticity in Malaria Parasites

mBio, 2018
In the malaria parasite Plasmodium falciparum, synthesis of isoprenoids from glycolytic intermediates is essential for survival. The antimalarial fosmidomycin (FSM) inhibits isoprenoid synthesis. In P.
Ann M. Guggisberg, Philip M. Frasse, Andrew J. Jezewski, Natasha M. Kafai, Aakash Y. Gandhi, Samuel J. Erlinger, Audrey R. Odom John   +6 more
doaj   +1 more source

Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. [PDF]

, 2006
3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is a critical enzyme in the mevalonate pathway that regulates the biosynthesis of cholesterol as well as isoprenoids that mediate the membrane association of certain GTPases.
Dunn, Shannon E, Goldstein, Matthew J, Prod'homme, Thomas, Steinman, Lawrence, Weber, Martin S, Youssef, Sawsan, Zamvil, Scott S   +6 more
core   +1 more source

From flavors and pharmaceuticals to advanced biofuels: Production of isoprenoids in Saccharomyces cerevisiae [PDF]

, 2013
Isoprenoids denote the largest group of chemicals in the plant kingdom and are employed for a wide range of applications in the food and pharmaceutical industry.
Ajikumar, Asadollahi, Basson, Boghigian, Bohlmann, Chang, Chappell, Cheng, Christensen, Collins, Croteau, Da Silva, Daum, Dugar, Dunlop, Engels, Farhi, Faulkner, Greenhagen, Harvey, Hong, Hu, Huang, Hui, Kampranis, Katsuki, Keasling, Kim, Kim, Krivoruchko, Lange, Lees, Li, Lurie, Lynen, Lücker, Mannan, Meigs, Michereff, Muramatsu, Murray, Murugesan, Naigre, Nielsen, Ohto, Oliveira, Oud, Pare, Partow, Parveen, Peralta-Yahya, Rohmer, Rude, Scalcinati, Scalcinati, Schiff, Sharon-Asa, Shearer, Song, Takahashi, Tracy, Tsuruta, Tu, Uribe, Wang, Wang, Wang, Westfall, Wilson, Yoshikuni, Zhang   +70 more
core   +2 more sources

The isoprenoid alcohol pathway, a synthetic route for isoprenoid biosynthesis [PDF]

Proceedings of the National Academy of Sciences, 2019
Significance We have demonstrated the design, prototyping, and implementation of a non-natural route to isoprenoid biosynthesis, termed the isoprenoid alcohol (IPA) pathway. Opposed to working within the confines of native metabolic pathways, our approach of utilizing all available biochemical reactions identified a synthetic route to ...
James M, Clomburg, Shuai, Qian, Zaigao, Tan, Seokjung, Cheong, Ramon, Gonzalez   +4 more
openaire   +2 more sources

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Human Isoprenoid Synthase Enzymes as Therapeutic Targets

Frontiers in Chemistry, 2014
The complex biochemical network known as the mevalonate pathway is responsible for the biosynthesis of all isoprenoids in the human body, which consists of a vast array of metabolites that are vital for proper cellular functions.
Jaeok ePark, Alexios eMatralis, Albert M. Berghuis, Youla S Tsantrizos   +3 more
doaj   +1 more source

Chemotypic variation explaining traditional selection of tropical root crops in Vanuatu, South Pacific [PDF]

, 2009
Understanding chemical variations in edible plant organs is essential for a better understanding of crop genetic diversity in traditional fields as well as for selection.
Bernillon, Stéphane, Champagne, Antoine, Hilbert, Ghislaine, Lebot, Vincent, Legendre, Laurent   +4 more
core