The Multifaceted MEP Pathway: Towards New Therapeutic Perspectives [PDF]
Molecules, 2023 Isoprenoids, a diverse class of natural products, are present in all living organisms. Their two universal building blocks are synthesized via two independent pathways: the mevalonate pathway and the 2-C-methyl-ᴅ-erythritol 4-phosphate (MEP) pathway. The
Alizée Allamand +4 more
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Effect of Drought on the Methylerythritol 4-Phosphate (MEP) Pathway in the Isoprene Emitting Conifer Picea glauca [PDF]
Frontiers in Plant Science, 2020 The methylerythritol 4-phosphate (MEP) pathway of isoprenoid biosynthesis produces chlorophyll side chains and compounds that function in resistance to abiotic stresses, including carotenoids, and isoprene.
Erica Perreca +6 more
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Targeting the IspD Enzyme in the MEP Pathway: Identification of a Novel Fragment Class [PDF]
ChemMedChem, 2022 The enzymes of the 2‐C‐methylerythritol‐d‐erythritol 4‐phosphate (MEP) pathway (MEP pathway or non‐mevalonate pathway) are responsible for the synthesis of universal precursors of the large and structurally diverse family of isoprenoids.
Eleonora Diamanti +2 more
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Cloning and Expression Analysis of MEP Pathway Enzyme-encoding Genes in Osmanthus fragrans [PDF]
Genes, 2016 The 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway is responsible for the biosynthesis of many crucial secondary metabolites, such as carotenoids, monoterpenes, plastoquinone, and tocopherols.
Huogen Li, Chunsun Gu, Yuanzheng Yue
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Investigating Novel IspE Inhibitors of the MEP Pathway in Mycobacterium. [PDF]
Microorganisms, 2023 In a recent effort to mitigate harm from human pathogens, many biosynthetic pathways have been extensively evaluated for their ability to inhibit pathogen growth and to determine drug targets.
Choi SR, Narayanasamy P.
europepmc +6 more sources
Systematic Analysis of Metabolic Bottlenecks in the Methylerythritol 4-Phosphate (MEP) Pathway of Zymomonas mobilis [PDF]
mSystems, 2023 Zymomonas mobilis is an industrially relevant aerotolerant anaerobic bacterium that can convert up to 96% of consumed glucose to ethanol. This highly catabolic metabolism could be leveraged to produce isoprenoid-based bioproducts via the methylerythritol
Daven B. Khana +10 more
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The eukaryotic MEP-pathway genes are evolutionarily conserved and originated from Chlaymidia and cyanobacteria [PDF]
BMC Genomics, 2021 Background Isoprenoids are the most ancient and essential class of metabolites produced in all organisms, either via mevalonate (MVA)-and/or methylerythritol phosphate (MEP)-pathways.
Liping Zeng, Katayoon Dehesh
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The yield of essential oils in Melaleuca alternifolia (Myrtaceae) is regulated through transcript abundance of genes in the MEP pathway. [PDF]
PLoS ONE, 2013 Medicinal tea tree (Melaleuca alternifolia) leaves contain large amounts of an essential oil, dominated by monoterpenes. Several enzymes of the chloroplastic methylerythritol phosphate (MEP) pathway are hypothesised to act as bottlenecks to the ...
Hamish Webb +4 more
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Expression and promoter analysis of MEP pathway enzyme-encoding genes in Pinus massoniana Lamb [PDF]
PeerJ, 2022 The methylerythritol phosphate (MEP) pathway provides the universal basic blocks for the biosynthesis of terpenoids and plays a critical role in the growth and development of higher plants.
Peihuang Zhu +4 more
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MEP pathway products allosterically promote monomerization of deoxy-D-xylulose-5-phosphate synthase to feedback-regulate their supply. [PDF]
Plant Commun, 2023 Isoprenoids are a very large and diverse family of metabolites required by all living organisms. All isoprenoids derive from the double-bond isomers isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), which are produced by the ...
Di X +8 more
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