The Multifaceted MEP Pathway: Towards New Therapeutic Perspectives [PDF]
Molecules, 2023 Isoprenoids, a diverse class of natural products, are present in all living organisms. Their two universal building blocks are synthesized via two independent pathways: the mevalonate pathway and the 2-C-methyl-ᴅ-erythritol 4-phosphate (MEP) pathway. The
Alizée Allamand +4 more
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The eukaryotic MEP-pathway genes are evolutionarily conserved and originated from Chlaymidia and cyanobacteria [PDF]
BMC Genomics, 2021 Background Isoprenoids are the most ancient and essential class of metabolites produced in all organisms, either via mevalonate (MVA)-and/or methylerythritol phosphate (MEP)-pathways.
Liping Zeng, Katayoon Dehesh
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Systematic Analysis of Metabolic Bottlenecks in the Methylerythritol 4-Phosphate (MEP) Pathway of Zymomonas mobilis [PDF]
mSystems, 2023 Zymomonas mobilis is an industrially relevant aerotolerant anaerobic bacterium that can convert up to 96% of consumed glucose to ethanol. This highly catabolic metabolism could be leveraged to produce isoprenoid-based bioproducts via the methylerythritol
Daven B. Khana +10 more
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Effect of Drought on the Methylerythritol 4-Phosphate (MEP) Pathway in the Isoprene Emitting Conifer Picea glauca [PDF]
Frontiers in Plant Science, 2020 The methylerythritol 4-phosphate (MEP) pathway of isoprenoid biosynthesis produces chlorophyll side chains and compounds that function in resistance to abiotic stresses, including carotenoids, and isoprene.
Erica Perreca +6 more
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Transcriptomic profiling reveals MEP pathway contributing to ginsenoside biosynthesis in Panax ginseng [PDF]
BMC Genomics, 2019 Background Panax ginseng C. A. Mey is one of famous medicinal herb plant species. Its major bioactive compounds are various ginsenosides in roots and rhizomes.
Le Xue +6 more
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Investigating Novel IspE Inhibitors of the MEP Pathway in Mycobacterium. [PDF]
Microorganisms, 2023 In a recent effort to mitigate harm from human pathogens, many biosynthetic pathways have been extensively evaluated for their ability to inhibit pathogen growth and to determine drug targets.
Choi SR, Narayanasamy P.
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Evolutionary flexibility and rigidity in the bacterial methylerythritol phosphate (MEP) pathway. [PDF]
Front Microbiol, 2023 Terpenoids are a diverse class of compounds with wide-ranging uses including as industrial solvents, pharmaceuticals, and fragrances. Efforts to produce terpenoids sustainably by engineering microbes for fermentation are ongoing, but industrial ...
Marshall B +4 more
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HDR, the last enzyme in the MEP pathway, differently regulates isoprenoid biosynthesis in two woody plants. [PDF]
Plant Physiol, 2023 Dimethylallyl diphosphate (DMADP) and isopentenyl diphosphate (IDP) serves as the universal C5 precursors of isoprenoid biosynthesis in plants. These compounds are formed by the last step of the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway ...
Krause T +9 more
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Hydroxymethylbutenyl diphosphate accumulation reveals MEP pathway regulation for high CO2-induced suppression of isoprene emission. [PDF]
Proc Natl Acad Sci U S A, 2023 Significance Isoprene has significant impacts on air quality and plant health. Because isoprene emission varies with changes in environmental conditions like light, temperature, and CO2, a mechanistic understanding of the regulation in the face of ...
Sahu A +3 more
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MEP pathway products allosterically promote monomerization of deoxy-D-xylulose-5-phosphate synthase to feedback-regulate their supply. [PDF]
Plant Commun, 2023 Isoprenoids are a very large and diverse family of metabolites required by all living organisms. All isoprenoids derive from the double-bond isomers isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), which are produced by the ...
Di X +8 more
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