The Multifaceted MEP Pathway: Towards New Therapeutic Perspectives [PDF]
Molecules, 2023 Isoprenoids, a diverse class of natural products, are present in all living organisms. Their two universal building blocks are synthesized via two independent pathways: the mevalonate pathway and the 2-C-methyl-ᴅ-erythritol 4-phosphate (MEP) pathway. The
Alizée Allamand +4 more
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Systematic Analysis of Metabolic Bottlenecks in the Methylerythritol 4-Phosphate (MEP) Pathway of Zymomonas mobilis [PDF]
mSystems, 2023 Zymomonas mobilis is an industrially relevant aerotolerant anaerobic bacterium that can convert up to 96% of consumed glucose to ethanol. This highly catabolic metabolism could be leveraged to produce isoprenoid-based bioproducts via the methylerythritol
Daven B. Khana +10 more
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Effect of Drought on the Methylerythritol 4-Phosphate (MEP) Pathway in the Isoprene Emitting Conifer Picea glauca [PDF]
Frontiers in Plant Science, 2020 The methylerythritol 4-phosphate (MEP) pathway of isoprenoid biosynthesis produces chlorophyll side chains and compounds that function in resistance to abiotic stresses, including carotenoids, and isoprene.
Erica Perreca +6 more
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The eukaryotic MEP-pathway genes are evolutionarily conserved and originated from Chlaymidia and cyanobacteria [PDF]
BMC Genomics, 2021 Background Isoprenoids are the most ancient and essential class of metabolites produced in all organisms, either via mevalonate (MVA)-and/or methylerythritol phosphate (MEP)-pathways.
Liping Zeng, Katayoon Dehesh
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Expression and promoter analysis of MEP pathway enzyme-encoding genes in Pinus massoniana Lamb [PDF]
PeerJ, 2022 The methylerythritol phosphate (MEP) pathway provides the universal basic blocks for the biosynthesis of terpenoids and plays a critical role in the growth and development of higher plants.
Peihuang Zhu +4 more
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Transcriptomic profiling reveals MEP pathway contributing to ginsenoside biosynthesis in Panax ginseng [PDF]
BMC Genomics, 2019 Background Panax ginseng C. A. Mey is one of famous medicinal herb plant species. Its major bioactive compounds are various ginsenosides in roots and rhizomes.
Le Xue +6 more
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Targeting the IspD Enzyme in the MEP Pathway: Identification of a Novel Fragment Class [PDF]
ChemMedChem, 2022 Markus Fischer +2 more
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Monoterpenoids Evolution and MEP Pathway Gene Expression Profiles in Seven Table Grape Varieties [PDF]
Plants, 2022 Baoqing Zhu, Lei Sun
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Cloning and Expression Analysis of MEP Pathway Enzyme-encoding Genes in Osmanthus fragrans [PDF]
Genes, 2016 Huogen Li +2 more
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Scientific Reports, 2021 Methyl erythritol phosphate (MEP) is the metabolite found in the MEP pathway for isoprenoid biosynthesis, which is known to be utilized by plants, algae, and bacteria. In this study, an unprecedented observation was found in the oleaginous yeast Yarrowia
Sivamoke Dissook +5 more
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