The Multifaceted MEP Pathway: Towards New Therapeutic Perspectives [PDF]
Molecules, 2023 Isoprenoids, a diverse class of natural products, are present in all living organisms. Their two universal building blocks are synthesized via two independent pathways: the mevalonate pathway and the 2-C-methyl-ᴅ-erythritol 4-phosphate (MEP) pathway. The
Michel Rohmer +2 more
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Effect of Drought on the Methylerythritol 4-Phosphate (MEP) Pathway in the Isoprene Emitting Conifer Picea glauca [PDF]
Frontiers in Plant Science, 2020 The methylerythritol 4-phosphate (MEP) pathway of isoprenoid biosynthesis produces chlorophyll side chains and compounds that function in resistance to abiotic stresses, including carotenoids, and isoprene.
Erica Perreca +6 more
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Systematic Analysis of Metabolic Bottlenecks in the Methylerythritol 4-Phosphate (MEP) Pathway of Zymomonas mobilis. [PDF]
MSystems, 2023 Zymomonas mobilis is an industrially relevant aerotolerant anaerobic bacterium that can convert up to 96% of consumed glucose to ethanol. This highly catabolic metabolism could be leveraged to produce isoprenoid-based bioproducts via the methylerythritol
Daniel Amador-Noguez, David M Stevenson
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Targeting the IspD Enzyme in the MEP Pathway: Identification of a Novel Fragment Class [PDF]
ChemMedChem, 2022 The enzymes of the 2‐C‐methylerythritol‐d‐erythritol 4‐phosphate (MEP) pathway (MEP pathway or non‐mevalonate pathway) are responsible for the synthesis of universal precursors of the large and structurally diverse family of isoprenoids.
Patricia Bravo +2 more
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The eukaryotic MEP-pathway genes are evolutionarily conserved and originated from Chlaymidia and cyanobacteria [PDF]
BMC Genomics, 2021 Background Isoprenoids are the most ancient and essential class of metabolites produced in all organisms, either via mevalonate (MVA)-and/or methylerythritol phosphate (MEP)-pathways.
Liping Zeng, Katayoon Dehesh
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Cloning and Expression Analysis of MEP Pathway Enzyme-encoding Genes in Osmanthus fragrans [PDF]
Genes, 2016 The 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway is responsible for the biosynthesis of many crucial secondary metabolites, such as carotenoids, monoterpenes, plastoquinone, and tocopherols.
Huogen Li, Liang-Gui Wang, Yuanzheng Yue
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Expression and promoter analysis of MEP pathway enzyme-encoding genes in Pinus massoniana Lamb [PDF]
PeerJ, 2022 The methylerythritol phosphate (MEP) pathway provides the universal basic blocks for the biosynthesis of terpenoids and plays a critical role in the growth and development of higher plants.
Peihuang Zhu +4 more
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Transcriptomic profiling reveals MEP pathway contributing to ginsenoside biosynthesis in Panax ginseng [PDF]
BMC Genomics, 2019 Background Panax ginseng C. A. Mey is one of famous medicinal herb plant species. Its major bioactive compounds are various ginsenosides in roots and rhizomes.
Le Xue +6 more
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Scientific Reports, 2021 Methyl erythritol phosphate (MEP) is the metabolite found in the MEP pathway for isoprenoid biosynthesis, which is known to be utilized by plants, algae, and bacteria. In this study, an unprecedented observation was found in the oleaginous yeast Yarrowia
Sivamoke Dissook +5 more
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Francisella tularensis 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase: kinetic characterization and phosphoregulation. [PDF]
PLoS ONE, 2011 Deliberate and natural outbreaks of infectious disease, the prevalence of antibiotic resistant strains, and the ease by which antibiotic resistant bacteria can be intentionally engineered all underscore the necessity of effective vaccines and continued ...
Arthur Tsang +5 more
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