Results 31 to 40 of about 15,771 (216)
Biochemical Journal, 2023 Isoprenoids, including dolichols (Dols) and polyprenols (Prens), are ubiquitous components of eukaryotic cells. In plant cells, there are two pathways that produce precursors utilized for isoprenoid biosynthesis: the mevalonate (MVA) pathway and the methylerythritol phosphate (MEP) pathway.
Agata Lipko +9 more
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Plants, 2020 The Madagascar periwinkle (Catharanthus roseus) synthesizes the highly valuable monoterpene indole alkaloids (MIAs) through a long metabolic route initiated by the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway. In leaves, a complex compartmentation of
Grégory Guirimand +14 more
doaj +1 more source
Frontiers in Plant Science, 2022 It is critical to develop plant isoprenoid production when dealing with human-demanded industries such as flavoring, aroma, pigment, pharmaceuticals, and biomass used for biofuels.
Ali Movahedi +11 more
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Investigating Novel IspE Inhibitor of MEP Pathway in Mycobacterium
, 2023 In a recent effort to mitigate harm from human pathogens, many biosynthetic pathways are extensively evaluated for their ability to inhibit pathogen growth and determine drug targets. Among those, one of the important products/targets of such pathways is isopentenyl diphosphate, the universal precursor of isoprenoids, which are essential for the normal
Seoung-ryoung Choi +1 more
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Mutations in Escherichia coli aceE and ribB genes allow survival of strains defective in the first step of the isoprenoid biosynthesis pathway. [PDF]
PLoS ONE, 2012 A functional 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway is required for isoprenoid biosynthesis and hence survival in Escherichia coli and most other bacteria.
Jordi Perez-Gil +9 more
doaj +1 more source
MEP pathway-mediated isopentenol production in metabolically engineered Escherichia coli [PDF]
Microbial Cell Factories, 2014 Isopentenols, such as prenol and isoprenol, are promising advanced biofuels because of their higher energy densities and better combustion efficiencies compared with ethanol. Microbial production of isopentenols has been developed recently via metabolically engineered E. coli.
Liu, Huaiwei +5 more
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CHIMIA, 2009 Isoprenoids (or terpenoids) are a large and structurally diverse class of biomolecules that are essential for the survival of all forms of life.
Christopher J. Thibodeaux, Hung-wen Liu
doaj +1 more source
Engineering Production of a Novel Diterpene Synthase Precursor in Nicotiana benthamiana
Frontiers in Plant Science, 2021 Diterpene biosynthesis commonly originates with the methylerythritol phosphate (MEP) pathway in chloroplasts, leading to the C20 substrate, geranylgeranyl pyrophosphate (GGPP).
Edith C. F. Forestier +4 more
doaj +1 more source
A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites [PDF]
Nature Communications, 2014 Isoprenoid biosynthesis through the methylerythritol phosphate (MEP) pathway generates commercially important products and is a target for antimicrobial drug development. MEP pathway regulation is poorly understood in microorganisms. Here we employ a forward genetics approach to understand MEP pathway regulation in the malaria parasite, Plasmodium ...
Guggisberg, Ann M +6 more
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Microbial Cell Factories, 2019 Background Terpenoids are of high interest as chemical building blocks and pharmaceuticals. In microbes, terpenoids can be synthesized via the methylerythritol phosphate (MEP) or mevalonate (MVA) pathways.
Daniel Christoph Volke +3 more
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