Results 31 to 40 of about 3,014,380 (256)

Expression of MEP Pathway Genes and Non-volatile Sequestration Are Associated with Circadian Rhythm of Dominant Terpenoids Emission in Osmanthus fragrans Lour. Flowers. [PDF]

Front Plant Sci, 2017
Osmanthus fragrans Lour. is one of the top 10 traditional ornamental flowers in China famous for its unique fragrance. Preliminary study proved that the terpenoids including ionone, linalool, and ocimene and their derivatives are the dominant aroma ...
Zheng R, Liu C, Wang Y, Luo J, Zeng X, Ding H, Xiao W, Gan J, Wang C.   +8 more
europepmc   +2 more sources

Enhanced C30 carotenoid production in Bacillus subtilis by systematic overexpression of MEP pathway genes [PDF]

Applied Microbiology and Biotechnology, 2015
Creating novel biosynthetic pathways and modulating the synthesis of important compounds are one of the hallmarks of synthetic biology. Understanding the key parameters controlling the flux of chemicals throughout a metabolic pathway is one of the ...
Dan Xue, Ingy I. Abdallah, Ilse E. M. de Haan, M. Sibbald, W. Quax   +4 more
semanticscholar   +4 more sources

Cervicomedullary motor evoked responses in individuals with severe chronic hemiparesis post-stroke: a feasibility study [PDF]

Frontiers in Neurology
Understanding the neural mechanisms underlying upper limb motor recovery after stroke remains a significant challenge in rehabilitation research. It has been proposed that individuals who show no motor-evoked potential (MEP) response to transcranial ...
Carley L. P. Butler, Carley L. P. Butler, Carley L. P. Butler, Carley L. P. Butler, Aditya Dutt, Carolee J. Winstein, Carolee J. Winstein, Monica A. Perez, Monica A. Perez, Monica A. Perez, Monica A. Perez, Mary Ellen Stoykov, Mary Ellen Stoykov   +12 more
doaj   +2 more sources

Stable isotope and chemical inhibition analyses suggested the existence of a non-mevalonate-like pathway in the yeast Yarrowia lipolytica

Scientific Reports, 2021
Methyl erythritol phosphate (MEP) is the metabolite found in the MEP pathway for isoprenoid biosynthesis, which is known to be utilized by plants, algae, and bacteria. In this study, an unprecedented observation was found in the oleaginous yeast Yarrowia
Sivamoke Dissook, Tomohisa Kuzuyama, Yuri Nishimoto, Shigeru Kitani, Sastia Putri, Eiichiro Fukusaki   +5 more
doaj   +1 more source

Francisella tularensis 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase: kinetic characterization and phosphoregulation. [PDF]

PLoS ONE, 2011
Deliberate and natural outbreaks of infectious disease, the prevalence of antibiotic resistant strains, and the ease by which antibiotic resistant bacteria can be intentionally engineered all underscore the necessity of effective vaccines and continued ...
Arthur Tsang, Heather Seidle, Safdar Jawaid, Weidong Zhou, Clint Smith, Robin D Couch   +5 more
doaj   +1 more source

Inhibition of DXR in the MEP pathway with lipophilic <i>N</i>-alkoxyaryl FR900098 analogs. [PDF]

RSC Med Chem
Isoprene biosynthesis is a point of vulnerability for many pathogens. Building on prior work, we report a novel set of potent compounds that display selectivity for P. falciparum over M. tuberculosis, and act on-target intracellularly.
Bague D, Wang R, Hodge D, Mikati MO, Roma JS, Boshoff HI, Dailey AL, Girma M, Couch RD, Odom John AR, Dowd CS.   +10 more
europepmc   +3 more sources

Enhanced metabolic flux of methylerythritol phosphate (MEP) pathway by overexpression of Ginkgo biloba 1-Hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate Reductase 1 (GbHDR1) gene in poplar

Applied Biological Chemistry, 2022
Terpenoids are of great interests in a broad range of health-beneficial biological activities and various industrial applications. In plants, terpenoids are synthesized by two distinct pathways, methylerythritol phosphate (MEP) and mevalonate pathways in
Min-Kyoung Kang, Ji-Young Kim, Young-Im Choi, Lujie Hu, Chaodong Yang, Zhehao Jin, Y. Park, Soo-un Kim, Sang-Min Kim   +8 more
semanticscholar   +1 more source

Kinetic characterization and allosteric inhibition of the Yersinia pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). [PDF]

PLoS ONE, 2014
The methylerythritol phosphate (MEP) pathway found in many bacteria governs the synthesis of isoprenoids, which are crucial lipid precursors for vital cell components such as ubiquinone.
Amanda Haymond, Chinchu Johny, Tyrone Dowdy, Brandon Schweibenz, Karen Villarroel, Richard Young, Clark J Mantooth, Trishal Patel, Jessica Bases, Geraldine San Jose, Emily R Jackson, Cynthia S Dowd, Robin D Couch   +12 more
doaj   +1 more source

Lipophilic prodrugs of FR900098 are antimicrobial against Francisella novicida in vivo and in vitro and show GlpT independent efficacy. [PDF]

PLoS ONE, 2012
Bacteria, plants, and algae produce isoprenoids through the methylerythritol phosphate (MEP) pathway, an attractive pathway for antimicrobial drug development as it is present in prokaryotes and some lower eukaryotes but absent from human cells.
Elizabeth S McKenney, Michelle Sargent, Hameed Khan, Eugene Uh, Emily R Jackson, Géraldine San Jose, Robin D Couch, Cynthia S Dowd, Monique L van Hoek   +8 more
doaj   +1 more source

Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). [PDF]

PLoS ONE, 2009
Deliberate and natural outbreaks of infectious disease underscore the necessity of effective vaccines and antimicrobial/antiviral therapeutics. The prevalence of antibiotic resistant strains and the ease by which antibiotic resistant bacteria can be ...
Safdar Jawaid, Heather Seidle, Weidong Zhou, Hafsa Abdirahman, Maher Abadeer, Joseph H Hix, Monique L van Hoek, Robin D Couch   +7 more
doaj   +1 more source