Results 11 to 20 of about 15,771 (216)

Reconstruction and evaluation of the synthetic bacterial MEP pathway in Saccharomyces cerevisiae. [PDF]

PLoS ONE, 2012
Isoprenoids, which are a large group of natural and chemical compounds with a variety of applications as e.g. fragrances, pharmaceuticals and potential biofuels, are produced via two different metabolic pathways, the mevalonate (MVA) pathway and the 2-C ...
Siavash Partow, Verena Siewers, Laurent Daviet, Michel Schalk, Jens Nielsen   +4 more
doaj   +4 more sources

Investigating Novel IspE Inhibitors of the MEP Pathway in Mycobacterium. [PDF]

Microorganisms, 2023
In a recent effort to mitigate harm from human pathogens, many biosynthetic pathways have been extensively evaluated for their ability to inhibit pathogen growth and to determine drug targets. One of the important products/targets of such pathways is isopentenyl diphosphate.
Choi SR, Narayanasamy P.
europepmc   +5 more sources

Evolutionary flexibility and rigidity in the bacterial methylerythritol phosphate (MEP) pathway. [PDF]

Front Microbiol, 2023
Terpenoids are a diverse class of compounds with wide-ranging uses including as industrial solvents, pharmaceuticals, and fragrances. Efforts to produce terpenoids sustainably by engineering microbes for fermentation are ongoing, but industrial production still largely relies on nonrenewable sources.
Marshall B, Amritkar K, Wolfe M, Kaçar B, Landick R.   +4 more
europepmc   +4 more sources

Sclareol and linalyl acetate are produced by glandular trichomes through the MEP pathway. [PDF]

Hortic Res, 2021
Abstract Sclareol, an antifungal specialized metabolite produced by clary sage, Salvia sclarea, is the starting plant natural molecule used for the hemisynthesis of the perfume ingredient ambroxide. Sclareol is mainly produced in clary sage flower calyces; however, the cellular localization of the sclareol biosynthesis remains unknown ...
Chalvin C, Drevensek S, Gilard F, Mauve C, Chollet C, Morin H, Nicol E, Héripré E, Kriegshauser L, Gakière B, Dron M, Bendahmane A, Boualem A.   +12 more
europepmc   +6 more sources

Francisella tularensis 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase: kinetic characterization and phosphoregulation. [PDF]

PLoS ONE, 2011
Deliberate and natural outbreaks of infectious disease, the prevalence of antibiotic resistant strains, and the ease by which antibiotic resistant bacteria can be intentionally engineered all underscore the necessity of effective vaccines and continued ...
Arthur Tsang, Heather Seidle, Safdar Jawaid, Weidong Zhou, Clint Smith, Robin D Couch   +5 more
doaj   +1 more source

Kinetic characterization and allosteric inhibition of the Yersinia pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). [PDF]

PLoS ONE, 2014
The methylerythritol phosphate (MEP) pathway found in many bacteria governs the synthesis of isoprenoids, which are crucial lipid precursors for vital cell components such as ubiquinone.
Amanda Haymond, Chinchu Johny, Tyrone Dowdy, Brandon Schweibenz, Karen Villarroel, Richard Young, Clark J Mantooth, Trishal Patel, Jessica Bases, Geraldine San Jose, Emily R Jackson, Cynthia S Dowd, Robin D Couch   +12 more
doaj   +1 more source

Lipophilic prodrugs of FR900098 are antimicrobial against Francisella novicida in vivo and in vitro and show GlpT independent efficacy. [PDF]

PLoS ONE, 2012
Bacteria, plants, and algae produce isoprenoids through the methylerythritol phosphate (MEP) pathway, an attractive pathway for antimicrobial drug development as it is present in prokaryotes and some lower eukaryotes but absent from human cells.
Elizabeth S McKenney, Michelle Sargent, Hameed Khan, Eugene Uh, Emily R Jackson, Géraldine San Jose, Robin D Couch, Cynthia S Dowd, Monique L van Hoek   +8 more
doaj   +1 more source

Combination of Entner-Doudoroff pathway with MEP increases isoprene production in engineered Escherichia coli. [PDF]

PLoS ONE, 2013
Embden-Meyerhof pathway (EMP) in tandem with 2-C-methyl-D-erythritol 4-phosphate pathway (MEP) is commonly used for isoprenoid biosynthesis in E. coli. However, this combination has limitations as EMP generates an imbalanced distribution of pyruvate and ...
Huaiwei Liu, Yuanzhang Sun, Kristine Rose M Ramos, Grace M Nisola, Kris Niño G Valdehuesa, Won-Keun Lee, Si Jae Park, Wook-Jin Chung   +7 more
doaj   +1 more source

Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). [PDF]

PLoS ONE, 2009
Deliberate and natural outbreaks of infectious disease underscore the necessity of effective vaccines and antimicrobial/antiviral therapeutics. The prevalence of antibiotic resistant strains and the ease by which antibiotic resistant bacteria can be ...
Safdar Jawaid, Heather Seidle, Weidong Zhou, Hafsa Abdirahman, Maher Abadeer, Joseph H Hix, Monique L van Hoek, Robin D Couch   +7 more
doaj   +1 more source

Inhibition of DXR in the MEP pathway with lipophilic <i>N</i>-alkoxyaryl FR900098 analogs. [PDF]

RSC Med Chem
Isoprene biosynthesis is a point of vulnerability for many pathogens. Building on prior work, we report a novel set of potent compounds that display selectivity for P. falciparum over M. tuberculosis , and act on-target intracellularly.
Bague D, Wang R, Hodge D, Mikati MO, Roma JS, Boshoff HI, Dailey AL, Girma M, Couch RD, Odom John AR, Dowd CS.   +10 more
europepmc   +3 more sources