A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites [PDF]
Nature Communications, 2014 Isoprenoid biosynthesis through the methylerythritol phosphate (MEP) pathway generates commercially important products and is a target for antimicrobial drug development. MEP pathway regulation is poorly understood in microorganisms.
Edwards, Rachel L +6 more
core +10 more sources
Cloning and Expression Analysis of MEP Pathway Enzyme-encoding Genes in Osmanthus fragrans. [PDF]
Genes (Basel), 2016 The 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway is responsible for the biosynthesis of many crucial secondary metabolites, such as carotenoids, monoterpenes, plastoquinone, and tocopherols.
Xu C +6 more
europepmc +7 more sources
Monoterpenoids Evolution and MEP Pathway Gene Expression Profiles in Seven Table Grape Varieties. [PDF]
Plants (Basel), 2022 This research investigated the evolution of both monoterpenoids and expression profiles of related biosynthesis genes in the MEP pathway in seven different table grape varieties from veraison to maturity stage in two seasons, and the correlation was ...
Zhou X +5 more
europepmc +5 more sources
Targeting the IspD Enzyme in the MEP Pathway: Identification of a Novel Fragment Class. [PDF]
ChemMedChem, 2022 The enzymes of the 2‐C‐methylerythritol‐d‐erythritol 4‐phosphate (MEP) pathway (MEP pathway or non‐mevalonate pathway) are responsible for the synthesis of universal precursors of the large and structurally diverse family of isoprenoids.
Diamanti E +8 more
europepmc +7 more sources
Sclareol and linalyl acetate are produced by glandular trichomes through the MEP pathway. [PDF]
Hortic Res, 2021 Sclareol, an antifungal specialized metabolite produced by clary sage, Salvia sclarea, is the starting plant natural molecule used for the hemisynthesis of the perfume ingredient ambroxide.
Chalvin C +12 more
europepmc +7 more sources
Growth medium-dependent antimicrobial activity of early stage MEP pathway inhibitors. [PDF]
PLoS One, 2018 The in vivo microenvironment of bacterial pathogens is often characterized by nutrient limitation. Consequently, conventional rich in vitro culture conditions used widely to evaluate antibacterial agents are often poorly predictive of in vivo activity ...
Sanders S +5 more
europepmc +6 more sources
Expression and promoter analysis of MEP pathway enzyme-encoding genes in Pinus massoniana Lamb [PDF]
PeerJ, 2022 The methylerythritol phosphate (MEP) pathway provides the universal basic blocks for the biosynthesis of terpenoids and plays a critical role in the growth and development of higher plants.
Peihuang Zhu +4 more
doaj +5 more sources
The MEP pathway in Babesia orientalis apicoplast, a potential target for anti-babesiosis drug development. [PDF]
Parasit Vectors, 2018 The apicomplexan parasite Babesia orientalis, the causative agent of water buffalo babesiosis in China, is widespread in central and south China, resulting in a huge economic loss annually.
He L +8 more
europepmc +6 more sources
The yield of essential oils in Melaleuca alternifolia (Myrtaceae) is regulated through transcript abundance of genes in the MEP pathway. [PDF]
PLoS ONE, 2013 Medicinal tea tree (Melaleuca alternifolia) leaves contain large amounts of an essential oil, dominated by monoterpenes. Several enzymes of the chloroplastic methylerythritol phosphate (MEP) pathway are hypothesised to act as bottlenecks to the ...
Hamish Webb +4 more
doaj +5 more sources
Effect of Drought and Methyl Jasmonate Treatment on Primary and Secondary Isoprenoid Metabolites Derived from the MEP Pathway in the White Spruce Picea glauca. [PDF]
Int J Mol Sci, 2022 White spruce (Picea glauca) emits monoterpenes that function as defensive signals and weapons after herbivore attack. We assessed the effects of drought and methyl jasmonate (MeJA) treatment, used as a proxy for herbivory, on monoterpenes and other ...
Perreca E +5 more
europepmc +2 more sources