Reconstruction and evaluation of the synthetic bacterial MEP pathway in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2012 Isoprenoids, which are a large group of natural and chemical compounds with a variety of applications as e.g. fragrances, pharmaceuticals and potential biofuels, are produced via two different metabolic pathways, the mevalonate (MVA) pathway and the 2-C ...
Siavash Partow +4 more
doaj +5 more sources
Mathematical modelling of the diurnal regulation of the MEP pathway in Arabidopsis
New Phytologist, 2015 Isoprenoid molecules are essential elements of plant metabolism. Many important plant isoprenoids, such as chlorophylls, carotenoids, tocopherols, prenylated quinones and hormones are synthesised in chloroplasts via the 2-C-methyl-d-erythritol 4 ...
Alexandra Pokhilko +2 more
exaly +5 more sources
Combination of Entner-Doudoroff pathway with MEP increases isoprene production in engineered Escherichia coli. [PDF]
PLoS ONE, 2013 Embden-Meyerhof pathway (EMP) in tandem with 2-C-methyl-D-erythritol 4-phosphate pathway (MEP) is commonly used for isoprenoid biosynthesis in E. coli. However, this combination has limitations as EMP generates an imbalanced distribution of pyruvate and ...
Huaiwei Liu +7 more
doaj +6 more sources
Transcriptomic profiling reveals MEP pathway contributing to ginsenoside biosynthesis in Panax ginseng [PDF]
BMC Genomics, 2019 Background Panax ginseng C. A. Mey is one of famous medicinal herb plant species. Its major bioactive compounds are various ginsenosides in roots and rhizomes.
Le Xue +6 more
doaj +5 more sources
Beyond the MEP Pathway: A novel kinase required for prenol utilization by malaria parasites. [PDF]
PLoS PathogA proposed treatment for malaria is a combination of fosmidomycin and clindamycin. Both compounds inhibit the methylerythritol 4-phosphate (MEP) pathway, the parasitic source of farnesyl and geranylgeranyl pyrophosphate (FPP and GGPP, respectively). Both
Crispim M +10 more
europepmc +6 more sources
Growth medium-dependent antimicrobial activity of early stage MEP pathway inhibitors. [PDF]
PLoS One, 2018 The in vivo microenvironment of bacterial pathogens is often characterized by nutrient limitation. Consequently, conventional rich in vitro culture conditions used widely to evaluate antibacterial agents are often poorly predictive of in vivo activity ...
Sanders S +5 more
europepmc +6 more sources
Divergent contribution of the MVA and MEP pathways to the formation of polyprenols and dolichols in Arabidopsis [PDF]
Biochemical Journal, 2023 Isoprenoids, including dolichols (Dols) and polyprenols (Prens), are ubiquitous components of eukaryotic cells. In plant cells, there are two pathways that produce precursors utilized for isoprenoid biosynthesis: the mevalonate (MVA) pathway and the ...
Hoffman-Sommer, Marta +9 more
core +4 more sources
Feedback regulation of the methylerythritol 4-phosphate (MEP) pathway [PDF]
, 2022 Els isoprenoides són una de les famílies més grans de metabòlits i tenen un gran interès en les indústries farmacèutiques, biocombustibles i agroalimentàries. Tots els isoprenoides deriven del difosfat d'isopentenil (IPP) i del seu isòmer de doble enllaç
Di, Xueni
core +6 more sources
Monoterpenoids Evolution and MEP Pathway Gene Expression Profiles in Seven Table Grape Varieties. [PDF]
Plants (Basel), 2022 This research investigated the evolution of both monoterpenoids and expression profiles of related biosynthesis genes in the MEP pathway in seven different table grape varieties from veraison to maturity stage in two seasons, and the correlation was ...
Zhou X +5 more
europepmc +2 more sources
Kinetic characterization and allosteric inhibition of the Yersinia pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). [PDF]
PLoS ONE, 2014 The methylerythritol phosphate (MEP) pathway found in many bacteria governs the synthesis of isoprenoids, which are crucial lipid precursors for vital cell components such as ubiquinone.
Amanda Haymond +12 more
doaj +2 more sources