The yield of essential oils in Melaleuca alternifolia (Myrtaceae) is regulated through transcript abundance of genes in the MEP pathway. [PDF]
PLoS ONE, 2013 Medicinal tea tree (Melaleuca alternifolia) leaves contain large amounts of an essential oil, dominated by monoterpenes. Several enzymes of the chloroplastic methylerythritol phosphate (MEP) pathway are hypothesised to act as bottlenecks to the ...
Hamish Webb +4 more
doaj +5 more sources
Combination of Entner-Doudoroff pathway with MEP increases isoprene production in engineered Escherichia coli. [PDF]
PLoS ONE, 2013 Embden-Meyerhof pathway (EMP) in tandem with 2-C-methyl-D-erythritol 4-phosphate pathway (MEP) is commonly used for isoprenoid biosynthesis in E. coli. However, this combination has limitations as EMP generates an imbalanced distribution of pyruvate and ...
Huaiwei Liu +7 more
doaj +2 more sources
Reconstruction and evaluation of the synthetic bacterial MEP pathway in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2012 Isoprenoids, which are a large group of natural and chemical compounds with a variety of applications as e.g. fragrances, pharmaceuticals and potential biofuels, are produced via two different metabolic pathways, the mevalonate (MVA) pathway and the 2-C ...
Siavash Partow +4 more
doaj +3 more sources
Investigating Novel IspE Inhibitors of the MEP Pathway in Mycobacterium. [PDF]
Microorganisms, 2023 In a recent effort to mitigate harm from human pathogens, many biosynthetic pathways have been extensively evaluated for their ability to inhibit pathogen growth and to determine drug targets.
Choi SR, Narayanasamy P.
europepmc +2 more sources
MEP pathway products allosterically promote monomerization of deoxy-D-xylulose-5-phosphate synthase to feedback-regulate their supply. [PDF]
Plant Commun, 2023 Isoprenoids are a very large and diverse family of metabolites required by all living organisms. All isoprenoids derive from the double-bond isomers isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), which are produced by the ...
Di X +8 more
europepmc +2 more sources
Divergent contribution of the MVA and MEP pathways to the formation of polyprenols and dolichols in Arabidopsis [PDF]
, 2023 Isoprenoids, including dolichols (Dols) and polyprenols (Prens), are ubiquitous components of eukaryotic cells. In plant cells, there are two pathways that produce precursors utilized for isoprenoid biosynthesis: the mevalonate (MVA) pathway and the ...
Hoffman-Sommer, Marta +9 more
core +1 more source
Kinetic characterization and allosteric inhibition of the Yersinia pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). [PDF]
PLoS ONE, 2014 The methylerythritol phosphate (MEP) pathway found in many bacteria governs the synthesis of isoprenoids, which are crucial lipid precursors for vital cell components such as ubiquinone.
Amanda Haymond +12 more
doaj +1 more source
Lipophilic prodrugs of FR900098 are antimicrobial against Francisella novicida in vivo and in vitro and show GlpT independent efficacy. [PDF]
PLoS ONE, 2012 Bacteria, plants, and algae produce isoprenoids through the methylerythritol phosphate (MEP) pathway, an attractive pathway for antimicrobial drug development as it is present in prokaryotes and some lower eukaryotes but absent from human cells.
Elizabeth S McKenney +8 more
doaj +1 more source
Feedback regulation of the methylerythritol 4-phosphate (MEP) pathway [PDF]
, 2022 Els isoprenoides són una de les famílies més grans de metabòlits i tenen un gran interès en les indústries farmacèutiques, biocombustibles i agroalimentàries. Tots els isoprenoides deriven del difosfat d'isopentenil (IPP) i del seu isòmer de doble enllaç
Di, Xueni
core +3 more sources