Double resolvability parameters of fosmidomycin anti-malaria drug and exchange property [PDF]
HeliyonThe practical and theoretical significance of the resolvability parameter makes it an important factor, particularly in the context of network analysis.
Rashad Ismail +2 more
exaly +4 more sources
Modified dosing schedule efficacy of fosmidomycin and clindamycin against murine malaria Plasmodium berghei [PDF]
International Journal for Parasitology: Drugs and Drug ResistanceFosmidomycin and clindamycin target the Plasmodium apicoplast. Combination clinical trials have produced mixed results with the primary problem being the recrudescent infection frequency by day 28.
Leah A. Walker +3 more
doaj +2 more sources
Population pharmacokinetics of fosmidomycin and clindamycin in combination with artesunate for uncomplicated Plasmodium falciparum malaria in Gabonese children and adults [PDF]
Malaria JournalBackground The increasing prevalence of artemisinin resistance in Plasmodium falciparum malaria highlights the urgent need for new, effective treatment strategies.
Christoph Pfaffendorf +8 more
doaj +2 more sources
In vitro activity of the antimalarial, antibiotic drugs fosmidomycin and clindamycin against clinical isolates of bacterial bloodstream infections in febrile, hospitalized Ghanaian children [PDF]
Malaria JournalBackground The clinical and laboratory distinction between malaria and bacterial blood stream infections in patients with undifferentiated fever remains challenging.
Christoph Pfaffendorf +10 more
doaj +2 more sources
Development and application of an LC–MS/MS method for quantification of fosmidomycin in human and rat plasma [PDF]
Malaria JournalBackground Malaria still poses a significant burden on global health, with millions of cases reported annually and rising resistance to current treatments, emphasizing the need for new therapeutic strategies.
Christoph Pfaffendorf +10 more
doaj +2 more sources
Over 40 Years of Fosmidomycin Drug Research: A Comprehensive Review and Future Opportunities [PDF]
Pharmaceuticals, 2022 To address the continued rise of multi-drug-resistant microorganisms, the development of novel drugs with new modes of action is urgently required.
Talea Knak +8 more
doaj +2 more sources
The Diverse Binding Modes Explain the Nanomolar Levels of Inhibitory Activities Against 1-Deoxy-d-Xylulose 5-Phosphate Reductoisomerase from Plasmodium falciparum Exhibited by Reverse Hydroxamate Analogs of Fosmidomycin with Varying N-Substituents [PDF]
MoleculesIt is established that reverse hydroxamate analogs of fosmidomycin inhibit the growth of Plasmodium falciparum by inhibiting 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR), the second enzyme of the non-mevalonate pathway, which is absent in humans.
Sana Takada +7 more
doaj +2 more sources
Isoprenoid alcohols utilization by malaria parasites [PDF]
Frontiers in Chemistry, 2022 Plasmodium falciparum is the etiological agent of human malaria, one of the most widespread diseases in tropical and subtropical regions. Drug resistance is one of the biggest problems in controlling the disease, which leads to the need to discover new ...
Ignasi Bofill Verdaguer +10 more
doaj +2 more sources
Antibiotic fosmidomycin protects bacteria from cell wall perturbations by antagonizing oxidative damage-mediated cell lysis [PDF]
Frontiers in MicrobiologyCell wall peptidoglycan is a defining component of bacterial cells, and its biosynthesis is a major target for medically important antibiotics. Recent studies have revealed that antibiotics can kill cells not only by their direct effects on wall ...
Yoshikazu Kawai, Jeff Errington
doaj +2 more sources
3D-printed wound dressings containing a fosmidomycin-derivative prevent Acinetobacter baumannii biofilm formation [PDF]
iScience, 2023 Summary: Acinetobacter baumannii causes a wide range of infections, including wound infections. Multidrug-resistant A. baumannii is a major healthcare concern and the development of novel treatments against these infections is needed.
Frits van Charante +11 more
doaj +2 more sources