Results 1 to 10 of about 1,235 (162)

Double resolvability parameters of fosmidomycin anti-malaria drug and exchange property [PDF]

Heliyon
The practical and theoretical significance of the resolvability parameter makes it an important factor, particularly in the context of network analysis.
Muhammad Azeem
exaly   +4 more sources

Inhibitory Effects of Fosmidomycin Against Babesia microti in vitro [PDF]

Frontiers in Cell and Developmental Biology, 2020
Babesia microti, the main pathogen causing human babesiosis, has been reported to exhibit resistance to the traditional treatment of azithromycin + atovaquone and clindamycin + quinine, suggesting the necessity of developing new drugs.
Sen Wang, Sen Wang, Muxiao Li, Muxiao Li, Xiaoying Luo, Xiaoying Luo, Long Yu, Long Yu, Zheng Nie, Zheng Nie, Qin Liu, Qin Liu, Xiaomeng An, Xiaomeng An, Yangsiqi Ao, Yangsiqi Ao, Qin Liu, Jiaxu Chen, Yu Tian, Junlong Zhao, Junlong Zhao, Junlong Zhao, Lan He, Lan He, Lan He   +24 more
doaj   +3 more sources

Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake [PDF]

BMC Microbiology, 2008
Fosmidomycin is a phosphonic antibiotic which inhibits 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr), the first committed step of the non-mevalonate pathway of isoprenoid biosynthesis.
Parish Tanya, Brown Amanda C
doaj   +3 more sources

Sub-inhibitory fosmidomycin exposures elicits oxidative stress in Salmonella enterica serovar Typhimurium LT2. [PDF]

PLoS ONE, 2014
Fosmidomycin is a time-dependent nanomolar inhibitor of methylerythritol phosphate (MEP) synthase, which is the enzyme that catalyzes the first committed step in the MEP pathway to isoprenoids.
David T Fox, Emily N Schmidt, Hongzhao Tian, Suraj Dhungana, Michael C Valentine, Nicole V Warrington, Paul D Phillips, Kellan B Finney, Emily K Cope, Jeff G Leid, Charles A Testa, Andrew T Koppisch   +11 more
doaj   +1 more source

Over 40 Years of Fosmidomycin Drug Research: A Comprehensive Review and Future Opportunities

Pharmaceuticals, 2022
To address the continued rise of multi-drug-resistant microorganisms, the development of novel drugs with new modes of action is urgently required.
Talea Knak, Mona A. Abdullaziz, Stefan Höfmann, Leandro A. Alves Avelar, Saskia Klein, Matthew Martin, Markus Fischer, Nobutada Tanaka, Thomas Kurz   +8 more
doaj   +1 more source

Pharmacokinetics and pharmacodynamics of fosmidomycin monotherapy and combination therapy with clindamycin in the treatment of multidrug resistant falciparum malaria

Malaria Journal, 2007
Background The study investigated the pharmacokinetics of fosmidomycin when given alone and in combination with clindamycin in patients with acute uncomplicated falciparum malaria. Methods A total of 15 and 18 patients with acute uncomplicated Plasmodium
Chauemung Anurak, Karbwang Juntra, Ruengweerayut Ronnatrai, Na-Bangchang Kesara, Hutchinson David   +4 more
doaj   +1 more source

α,α-Difluorophosphonohydroxamic Acid Derivatives among the Best Antibacterial Fosmidomycin Analogues

Molecules, 2021
Three α,α-difluorophosphonate derivatives of fosmidomycin were synthesized from diethyl 1,1-difluorobut-3-enylphosphonate and were evaluated on Escherichia coli.
Aurore Dreneau, Fanny S. Krebs, Mathilde Munier, Chheng Ngov, Denis Tritsch, Didier Lièvremont, Michel Rohmer, Catherine Grosdemange-Billiard   +7 more
doaj   +1 more source

Resistance of Francisella novicida to Fosmidomycin Associated with Mutations in the Glycerol-3-Phosphate Transporter

Frontiers in Microbiology, 2012
The methylerythritol phosphate (MEP) pathway is essential in most prokaryotes and some lower eukaryotes but absent from human cells, and is a validated target for antimicrobial drug development.
Ryan S Mackie, Ryan S Mackie, Elizabeth S McKenney, Monique L van Hoek, Monique L van Hoek   +4 more
doaj   +1 more source

Predicting Drug Resistance Using Deep Mutational Scanning

Molecules, 2020
Drug resistance is a major healthcare challenge, resulting in a continuous need to develop new inhibitors. The development of these inhibitors requires an understanding of the mechanisms of resistance for a critical mass of occurrences.
Gur Pines, Reilly G. Fankhauser, Carrie A. Eckert   +2 more
doaj   +1 more source

Assessment of the pharmacokinetics and dynamics of two combination regimens of fosmidomycin-clindamycin in patients with acute uncomplicated falciparum malaria

Malaria Journal, 2008
Background This study investigated the pharmacokinetics of fosmidomycin when given in combination with clindamycin at two dosage regimens in patients with acute uncomplicated falciparum malaria.
Chauemung Anurak, Hutchinson David, Looareesuwan Sornchai, Ruangweerayut Ronnatrai, Banmairuroi Vick, Na-Bangchang Kesara   +5 more
doaj   +1 more source